Navigation Links
Blind mice can 'see' thanks to special retinal cells
Date:7/14/2010

distance of 20 feet what the "average" human being can see at that distance. In contrast, a person with "20/100" vision would have to stand 20 feet away from, for instance, an eye chart that the average person could read from 100 feet away. People with very low visual acuity (worse than "20/100" with corrective lenses) are considered "legally blind."

In addition to providing hope for people with serious vision problems, Hattar's findings hint that, in the past, mammals may have used their ipRGCs for sight/image formation, but during the course of evolution, that function was somehow taken over by rods and cones.

The study also concludes that, far from being homogenous, ipRGCs come in five different subtypes, with the possibility that each may have different light-detecting physiological functions.

To conduct the study, the team used a special system to genetically label cells and then "trace" them to the rodents' brains before subjecting the mice to a number of vision tests. In one, mice followed the movements of a rotating drum, a test that assessed the animals' ability to track moving objects. In another, the rodents were placed within a "Y"-shaped maze and challenged to escape by selecting the lever that would let them out. That lever was associated with a certain visual pattern. The mice that were blind -- they lacked rods, cones and ipRGCs -- couldn't find that lever. But those with only ipRGCs could.

"These studies are extremely exciting to me, because they show that even a simple light-detecting system like ipRGCs has incredible diversity and may support low-acuity vision, allowing us to peer into evolution to understand how simple vision may have originally evolved before the introduction of the fancy photoreceptors rods and cones," Hattar said.


'/>"/>

Contact: Lisa DeNike
Lde@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Genetic finding implicates innate immune system in major cause of blindness
2. ORNL, Southern Cal set sights on preventing blindness
3. Researchers develop flow sensors based on hair structures of blind cavefish
4. Work in mice will contribute to the study of hereditary diseases that lead to blindness
5. MSU researcher identifies cell mechanism leading to diabetic blindness
6. Caltech scientists create robot surrogate for blind persons in testing visual prostheses
7. Bat researchers no longer flying blind on echolocation
8. Experimental treatments restore partial vision to blind people
9. Discovery points toward anti-inflammation treatment for blinding disease
10. Visual assistance for cosmic blind spots
11. Scripps research team reveals how an old drug could have a new use for treating river blindness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blind mice can 'see' thanks to special retinal cells
(Date:12/17/2014)... Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ... – with the clinical data to back it up," ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... introduced to regions beyond their native range carry ... are responsible for the loss of natural resources and biodiversity, ... Not all non-native species pose a threat. Scientists around the ... conditions that set the stage for debilitating invaders, like ...
... The Dead Sea, a salt sea without an outlet, ... its high salt content because it increases their buoyancy. ... popular archive that provides a diachronic view of its ... Steinmann-Institute for Geology, Mineralogy and Paleontology at the University ...
... framework to evaluate the risk of resistance for the ... this work: A framework for assessing the risk of ... the Malaria Journal today. Resistance ... is important when developing new medicines for malaria, to ...
Cached Biology News:Losing stream in our battle to predict and prevent invasive species 2Losing stream in our battle to predict and prevent invasive species 3Drastic desertification 2Drastic desertification 3MMV develops framework to assess risk of resistance for antimalarial compounds 2
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... it will hold its 2015 Annual Meeting of Stockholders ... Because the expected date for the Annual Meeting represents ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... webinar series is designed to introduce cutting ... inform users and partners of platform upgrades. ... and benefits; empowering users in their quest ... powerful tools. , According to SoundConnect’s Marketing ...
(Date:12/24/2014)... Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading ... reproductive medicine. In his new role as treasurer, ... board and will have a voice in furthering the ... supported ASRM since 1984 when he joined while conducting ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... FLEMINGTON, N.J. , June 24 Beardsworth Consulting ... as the company,s Scientific Advisor, Oncology and Robert W. Malone , ... , , ... oncology,s respected research leaders with over 20 years of clinical research experience. ...
... HOPKINTON, Mass. , June 25 Caliper Life Sciences, ... services for drug discovery and life sciences research, hosted its 2010 ... and 10. This thought-leadership conference is focused on sharing knowledge, ... leading to the next generation of breakthrough diagnostics and therapies. , ...
... BERLIN , June ... worldwide by 10 to 20 percent per year through ... accelerate R&D and,commercialization in this nascent industry, making it ... market demand. Representatives from,Germany Trade & Invest will be ...
Cached Biology Technology:Alison Martin, MD and Robert W. Malone, MD Join Beardsworth 2Caliper Owners Group Meeting Showcases Critical Role of Biopharma and Academic Researchers for Improving Healthcare and Quality of Life 2Caliper Owners Group Meeting Showcases Critical Role of Biopharma and Academic Researchers for Improving Healthcare and Quality of Life 3Market Demand and Innovation in Germany Propel Industrial Biotechnology Growth 2Market Demand and Innovation in Germany Propel Industrial Biotechnology Growth 3
... derived from Paraffin embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 5 ... are large (3-5mm in diameter) in comparison ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... The new MyiQ real-time PCR detection ... detection of common green fluorescent dyes such ... system interfaces directly with the iCycler thermal ... gradient and Peltier-effect driven performance. The MyiQ ...
... are highly sensitive laser confocal systems designed ... advanced scanners that meet your expectations, differentiating ... and optimizing the signal on the bottom ... the range for increased sensitivity. Results with ...
Biology Products: