Navigation Links
Blind flies without recycling
Date:3/18/2013

mine. In previous studies, Bochum's biochemists already demonstrated that histamine is recycled via the glial cells surrounding the photoreceptors. There, the enzyme Ebony inactivates the neurotransmitter histamine by binding it to the amino acid -alanine, thus creating -alanyl-histamine. This molecule is transported from the glial cells back into the photoreceptors. Here, -alanine is split off again by the enzyme Tan, and histamine is produced. Previously, it was assumed that the enzyme Black is responsible for producing the -alanine, which is required for the inactivation of histamine. However, if a fly's eye has no functional Black, the visual process still runs normally. Hovemann's team therefore looked into the question of whether there is another supply route for -alanine. They also tested whether the fly eye can get around the recycling of histamine; this would be possible if the photoreceptors could directly reabsorb the released neurotransmitter, without it being inactivated in the glial cells.

No functioning sense of sight without histamine recycling

The researchers examined flies that were neither able to produce histamine themselves nor recycle it, because they lacked the enzyme for histamine synthesis and the enzyme Ebony. The team measured the flies' vision using so-termed electroretinography, which not only shows the excitation of the photoreceptor cells, but also the transmission of the signal to the brain. Even when the researchers added histamine from outside, the flies were blind. With this test, they showed for the first time that, for vision, Drosophila is dependent on the histamine recycling in the glial cells. Without recycling the enzyme Ebony, the cells in the insect eye cannot make any use of the neurotransmitter.

Flies can also see with disturbed -alanine production

Cells are not only able to produce -alanine with the aid of the enzyme Black, but also by converting the molecule uraci
'/>"/>

Contact: Bernhard Hovemann
Bernhard.Hovemann@rub.de
49-234-322-4235
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Long-suspected cause of blindness from eye disease disproved
2. First in the world - Singapore scientists discover genes responsible for cornea blindness
3. Blind patient reads words stimulated directly onto the retina
4. Cells from skin create model of blinding eye disease
5. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
6. New cause of child blindness identified
7. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
8. Antioxidant shown to reduce blindness risk in extremely premature babies
9. UF study shows spiders, not birds, may drive evolution of some butterflies
10. Fruit flies force their young to drink alcohol -- for their own good
11. Pirate-like flies connect symbiosis to diversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform ... State of Washington,s Department of Licensing, in the ... issuance system for driver,s licenses and identification cards to its ... development will start in January 2015, with enrollment and card ...
(Date:1/22/2015)... MELBOURNE, Fla. , Jan. 13, 2015  Today, ... wearable technology, launched its crowdfunding campaign on Fundable, ... accelerate the build of production capacity to meet ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... Jan. 15, 2015  BellBrook Labs, a leader in ... the launch of a TR-FRET (time resolved Forster ... UDP Assay, a high throughput screening assay for ... will allow for sensitive detection of hundreds of ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... team of Duke Medicine researchers has engineered cartilage from induced ... use in tissue repair and studies into cartilage injury and ... in the journal the Proceedings of the National Academy ... or iPSCs, may be a viable source of patient-specific articular ...
... The Journal of Cell Biology shows how ... nerve cells to help prevent neurodegeneration. The findings could pave ... in patients with neurodegenerative diseases. In Lou Gehrig,s ... in stages, with axons deteriorating first and the cells themselves ...
... who have lost a substantial amount of weight after ... their siblings who were born before the weight loss ... weight loss that occur after the surgery have a ... according to a new study presented at the Canadian ...
Cached Biology News:Duke researchers engineer cartilage from pluripotent stem cells 2Stay-at-home transcription factor prevents neurodegeneration 2Obese moms give birth to heart healthier kids following bariatric surgery 2Obese moms give birth to heart healthier kids following bariatric surgery 3
(Date:1/22/2015)... The laboratory information management systems market ... number of technological advancements due to factors such as ... to integrate healthcare systems, and increasing government support for ... integration. Key players in the market focus on technological ...
(Date:1/22/2015)... January 22, 2015 Pipette.com has added ... to their comprehensive portfolio of Eppendorf products. , The ... purchase a Centrifuge 5424/5424 R and receive the following:, ... Eppendorf Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero ... for Biomedical Research abre hoy su llamada a nominaciones ... cuya investigación científica ha hecho, o tiene el potencial ... salud humana. Las nominaciones se aceptarán hasta el 15 ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... Meeting of the American ... Association for Cancer Research (AACR) -, TORONTO, ... AMEX: LRP), a biopharmaceutical company specializing,in the research, development ... of cancer, today announced,presentations of further preclinical data from ...
... and its US,affiliate EMD Serono, Inc., both part ... expansion of EMD Serono,s US presence with an,anticipated ... northwest,of Boston, Massachusetts. The company anticipates that this ... Massachusetts., The investment will support the construction ...
... Technology (NIST), in collaboration with the National Aeronautics ... for making essential measurements on samples of single-walled ... current best practices for characterizing one of the ... generation of nanoscale materials. , The nanotubes are ...
Cached Biology Technology:Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040 2Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040 3Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040 4EMD Serono Announces Planned Investment of $50 Million in Research Center in Massachusetts 2EMD Serono Announces Planned Investment of $50 Million in Research Center in Massachusetts 3EMD Serono Announces Planned Investment of $50 Million in Research Center in Massachusetts 4Carbon nanotube measurements: latest in NIST 'how-to' series 2
... analysis in a modern flow cytometer, a ... are differentially labeled with fluorescent probes. However, ... used for cell labeling are broader than ... flow cytometers filters. Thus, the fluorescence signal ...
This free-standing laminar flow hood provides a vertical flow of HEPA-filtered air to create a clean processing area. It includes a fluorescent light and motorized sliding shield. Options include wor...
... ,Product Information , ... high quality, general purpose shaker with economical analog ... models in the line, the Orbit LS features ... Electronic controls are utilized for setting speed and ...
This modular laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Configurations are available with vertical or horizontal flow; options include a wo...
Biology Products: