Navigation Links
Bleeding symptom leads scientists to intracellular trafficker's role in virus propagation
Date:11/14/2013

Rodent-borne pathogens like hantaviruses and arenaviruses are simple, but resourceful, and very successful at propagating. Due to a tiny genome generating a mere four proteins compared to humans' thousands, they rely on human biological machinery to do their replication dirty work, facilitating infection, plus a high mortality rate. Vermont researchers have discovered a mechanism that when targeted, may stop these deadly viruses in their tracks.

A new study published in Cell Host & Microbe by the University of Vermont's Jason Botten, Ph.D., assistant professor of medicine and microbiology and molecular genetics, and graduate student Joseph Klaus and colleagues offers a paradigm shift for scientists' understanding of the functionality of a protein that resides in the cell's secretory pathway and gets "shuttled" from one end of the cell to the other.

Antivirals or vaccines do not exist for these pathogens, so gaining a better understanding of how they replicate was at the heart of Botten and colleagues' investigation.

"The 'catch' with these viruses is that each different species has a tailor-made mouse host, like a deer mouse, white-footed mouse, etc.," explains Botten. In addition, he says, because these viruses and their rodent hosts have co-evolved for millions of years, they do not cause any apparent disease in the mice. "It's a beautiful relationship," he remarks, noting that because these viruses are not dependent on humans for their maintenance in nature, when humans do get infected, they get very sick.

The team closely examined the interaction between the virus proteins and the host proteins, a process that yielded the creation of a map the first ever of human protein partners of arenavirus and hantavirus glycoproteins (GPs). "The mapping allowed all kinds of analysis regarding which pathways of human cells the virus is tapping into," says Botten.

GPs reside on the surface of the virus and allow i
'/>"/>

Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-656-7875
University of Vermont
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stem cells enable personalised treatment for bleeding disorder
2. Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice
3. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
4. Calcium plus vitamin D supplementation does not reduce joint symptoms in postmenopausal women
5. Changes to symptom structure in DSM-5 support diagnosis of toddlers with autism spectrum disorder
6. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?
7. Complex genetic architectures: Some common symptoms of trisomy 21
8. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
9. Pitt team finds melatonin delays ALS symptom onset and death in mice
10. In autism, age at diagnosis depends on specific symptoms
11. Folate and vitamin B12 reduce disabling schizophrenia symptoms in some patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... the "Micro Market Monitor: North America Perimeter Security ... http://photos.prnewswire.com/prnh/20130307/600769 The North ... a CAGR of 3.6% from 2014 to 2019. Although ... market, Canada is expected to ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... and toxinologist Zoltan Takacs, PhD, a research associate ... has been named to the 2010 class of ... interest in drug development with exotic travel, venomous ... "visionary, young trailblazers" from around the world making ...
... MBL, WOODS HOLE, MAMitchell Sogin of the Marine Biological Laboratory ... from Ion Torrent of Guilford, Conn., and San Francisco. ... Ion PGM sequencer, a DNA sequencing system that directly translates ... 1) on a semiconductor chip. The result is a sequencing ...
... 2010 Grazinglands represent one of the largest land resources ... sources of greenhouse gases is essentially unknown. Previous research has ... atmospheric carbon dioxide as soil organic carbon. However, there is ... flux of two potent GHGs, nitrous oxide and methane. ...
Cached Biology News:National Geographic names University of Chicago researcher an 'Emerging Explorer for 2010' 2National Geographic names University of Chicago researcher an 'Emerging Explorer for 2010' 3National Geographic names University of Chicago researcher an 'Emerging Explorer for 2010' 4MBL scientist awarded next-generation DNA sequencer to monitor water quality 2How grazing lands influence greenhouse gas 2
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation ... Medtronic, Inc. (NYSE: MDT ) has ... Food and Drug Administration (FDA) for the use ... infusion system (including a newly developed catheter) for ... Injection delivered intravenously to patients with pulmonary arterial ...
(Date:12/24/2014)... GMO corn cases filed across the United ... the process of being consolidated in a Kansas federal ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. ... of Kansas. , Management of the Syngenta GMO corn ... District Judge John W. Lungstrum.* , As a Missouri ...
(Date:12/24/2014)... December 23, 2014 The ... such as its definition, classification, application and ... specification, manufacturing process, and product cost structure. ... applications. The analysis also covers upstream raw ... industry development trend and proposals. In the ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... FRANCISCO, December 13 Synosia Therapeutics today,announced the ... new,chief business officer, effective immediately., Dr Blanc, ... in Basel,Switzerland, joins from Syngenta, where he created ... by training and an,experienced biotech entrepreneur, Dr. Blanc ...
... N.J., Dec. 12 Datascope Corp.,(Nasdaq: DSCP ... one of the nation,s,leading independent proxy advisory firms, ... James J. Loughlin and William,L. Asmundson -- at ... 20, 2007. To follow Glass Lewis, recommendation,Datascope shareholders ...
... -- Record revenues of $82.0 million, up 22% from the prior year,s fourth ... quarter ... over last year,s ... debt facility paid off, -- Launch of four new food and beverage products and one new pregnancy and ...
Cached Biology Technology:Synosia Therapeutics Announces Appointment of Chief Business Officer 2Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 2Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 3Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 4Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 5Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 6Glass Lewis Recommends Datascope Shareholders Vote for Re-Election of the Board's Directors 7Martek Announces Fourth Quarter and FY 2007 Financial Results 2Martek Announces Fourth Quarter and FY 2007 Financial Results 3Martek Announces Fourth Quarter and FY 2007 Financial Results 4Martek Announces Fourth Quarter and FY 2007 Financial Results 5Martek Announces Fourth Quarter and FY 2007 Financial Results 6Martek Announces Fourth Quarter and FY 2007 Financial Results 7Martek Announces Fourth Quarter and FY 2007 Financial Results 8Martek Announces Fourth Quarter and FY 2007 Financial Results 9Martek Announces Fourth Quarter and FY 2007 Financial Results 10Martek Announces Fourth Quarter and FY 2007 Financial Results 11Martek Announces Fourth Quarter and FY 2007 Financial Results 12Martek Announces Fourth Quarter and FY 2007 Financial Results 13Martek Announces Fourth Quarter and FY 2007 Financial Results 14Martek Announces Fourth Quarter and FY 2007 Financial Results 15
... cooling coil, Trans-Blot cell, provides ... high-intensity, and extended electrophoretic transfer ... Trans-Blot cell. Use of the ... to an external water recirculator, ...
... of next-generation features into a small-footprint design, ... flexible laboratory solutions. It puts every aspect ... dispensing, and integrations into a single, ... as it is efficient and economical. The ...
... Biomek FX P is the latest entry ... for greater positional accuracy and increased robustness, it ... application. It can be configured with either one ... capacity, the Biomek FX P sets the ...
These Costar 96-well, flat-bottom polystyrene EIA plates are used for EIAs, ELISAs, and other protein binding assays. Supplied as box of 100 (20 packages; 5 plates per package)....
Biology Products: