Navigation Links
Bladder function restored in animals with severe spinal cord injury
Date:6/26/2013

For the first time, researchers have restored significant bladder function through nerve regeneration in rats with the most severe spinal cord injuries (SCI). The breakthrough paired a traditional nerve bridge graft with a novel combination of scar degrading and growth factor treatments to grow new nerve cells from the thoracic level to the lower spinal cord region. Details of the discovery appear in the June 26 issue of the Journal of Neuroscience.

Neuroscientists from Case Western Reserve University School of Medicine and Cleveland Clinic built a regeneration bridge across a lesion in animals with complete gap transections of their spinal cords. Although the animals did not regain the ability to walk, the procedure did allow them to recover a strong level of bladder control.

Jerry Silver, PhD, professor of neurosciences at the School of Medicine, and Yu-Shang Lee, PhD, assistant staff scientist in the Lerner Research Institute of Cleveland Clinic, created the bridge using a scaffold of multiple segments of the animals' own peripheral nerves. Key to the regeneration was surrounding the graft and both spinal cord stumps with a stimulating growth factor and an enzyme to dissolve scar tissue, which inhibits the nerve fibers from crossing over the bridge and traveling down the spinal cord.

"While urinary control is complex and recovery took several months, it was clear that this primitive function lost to spinal cord injury does possess the capacity to rewire itself, even when a relatively small number of axons are regenerated," Silver said.

The spinal cord's role in bladder function is critical, as it relays information between the brain and body. After suffering SCI, urinary dysfunction occurs. The loss of control happens because the axons, or nerve fibers which transmit information from neuron to neuron, are disconnected from the brain stem where the body's urination commands reside.

The creation of the ne
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
2. Cichlid fish: How does the swim bladder affect hearing?
3. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
4. Bone marrow cells used in bladder regeneration
5. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
6. CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control
7. Genetic alterations linked with bladder cancer risk, recurrence, progression, and patient survival
8. AACR news: Little molecule makes big difference in bladder cancer metastasis
9. Study demonstrates cells can acquire new functions through transcriptional regulatory network
10. Has modern science become dysfunctional?
11. Second-generation drug used for hypertension aids heart function independent of blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... the Indiana University School of Public Health-Bloomington has bolstered ... by finding a strong association between heme iron, found ... , The study found that heme iron consumption increased ... while no association was found between nonheme iron, which ... heart disease. , The study was published online ahead ...
(Date:4/23/2014)... that male black widow spiders prefer their female mates ... mate preference by male spiders. , The ... Andrade, a professor in UTSC,s Department of Biological Sciences, ... that males overwhelmingly chose to mate with well-fed, unmated ... whether a potential mate is well-fed and unmated by ...
(Date:4/23/2014)... accurate group decision increases with the abundance of brains ... a variety of factors as often happens in ... smaller groups actually tend to make more accurate decisions ... certain pieces of information. , The findings present a ... or the "wisdom of crowds," wherein individual observations ...
Breaking Biology News(10 mins):Study: Iron consumption can increase risk for heart disease 2Picky male black widow spiders prefer well-fed virgins 2Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... New insights into the human immunodeficiency virus (HIV) infection ... now be possible through a research method recently developed ... Technology (NIST), where scientists have glimpsed an important protein ... known as Gag, plays several critical roles in the ...
... a lot going for it sweet, low calorie, high ... a pilot study led by food scientists at The Florida ... weapon against prehypertension, a precursor to cardiovascular disease. ... FSU Assistant Professor Arturo Figueroa and Professor Bahram H. Arjmandi ...
... Rochelle, NY, October 13, 2010Parents of children with undiagnosed ... host of psychological and social challenges, which are explored ... Testing and Molecular Biomarkers , a peer-reviewed journal published ... article is available free online ahead of print at ...
Cached Biology News:New look at multitalented protein sheds light on mysteries of HIV 2Florida State study finds watermelon lowers blood pressure 2Florida State study finds watermelon lowers blood pressure 3Unexplained childhood disorders 2
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... This release is available in German . ... at the Vienna University of Technology are interested in gold at ... most reactive catalysts for chemical reactions. However, when gold atoms are ... nuggets consisting of several atoms. A team of surface scientists now ...
... formation of a new Contract Research Organization (CRO), Agility ... providing customized clinical research and consulting services to small ... companies.  The Company was formed by David F. Hale, ... According to Hale, "Agility,s mission is to provide ...
... Inc. (NYSE: WPI ), a leading specialty ... President and Chief Executive Officer, will provide an overview ... Sachs Global Healthcare Conference 2012 on Wednesday, June 6, ... in Rancho Palos Verdes, California.  The presentation will be ...
Cached Biology Technology:The finest gold dust in the world 2Agility Clinical, Inc., a Specialty Contract Research Organization is Formed 2Watson to Present at Goldman Sachs Global Healthcare Conference 2012 2
... agitation and temperature control for microbiology and ... independently and is suitable for DASGIP bioreactors ... volume. Its temperature ranges from approximately 10 ... is equipped with an individual electrical heating ...
RORgamma (S-14)...
... the only microplate sealer with an integrated ... times with a variety of configurations and ... with integrated stacker and 240-plate storage capacity ... use in small workcells , Handles all ...
... LC Sciences provides a comprehensive service ... high density peptide microarrays synthesized on ... using recombinant proteins/antibodies or serum samples. ... your sequence designs, binding assays using ...
Biology Products: