Navigation Links
Bladder cells feel stretch
Date:8/6/2009

Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki Sokabe (National Institute for Physiological Sciences: NIPS), and Prof. Masayuki Takeda, Dr. Isao Araki and Dr. Tsutomu Mochizuki (Yamanashi Univ.), found that bladder urothelial cells have a sensor for stretch stimulation. Their finding was reported in the Journal of Biological Chemistry published on Aug 7, 2009.

Bladder is known to release ATP that activates micturition reflex pathway during urine storage. However, it has been unknown how urothelial cells sense bladder distension. The research group examined the function of 'TRPV4' protein abundantly expressed in urothelial cells. The group developed a special apparatus to measure cell responses upon stretch stimulation, which mimics bladder distension.

Upon stretch stimulation, robust Ca2+ influx and following ATP release were observed in urothelial cells. These phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.

Dr. Sokabe said, "This is the first report to show that TRPV4 is a primal stretch-detector in urothelial cells. Given that TRPV4 is critically involved in the sensing mechanism in the bladder, development of chemicals modulating TRPV4 activity may be useful for treatment of bladder disorders such as overactive bladder and pollakiuria."


'/>"/>

Contact: Takaaki Sokabe
sokabe@nips.ac.jp
81-564-595-287
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
2. Bacteria that cause urinary tract infections invade bladder cells
3. Extract of broccoli sprouts may protect against bladder cancer
4. Selenium may prevent high risk-bladder cancer
5. Robo-surgery: As safe and capable as a human assistant in key-hole gallbladder removal
6. Chemical in blood may explain susceptibility to bladder pain
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. Newly created cancer stem cells could aid breast cancer research
9. AIDS interferes with stem cells in the brain
10. Clemson scientists shed light on molecules in living cells
11. Social habits of cells may hold key to fighting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... ... Markets has announced the addition of the "Global Military Biometrics Market ... the global military biometrics market to grow at a CAGR of 7.5% ... based on an in-depth market analysis with inputs from industry experts. The ... years. The report also includes a discussion of the key vendors operating ...
(Date:12/15/2016)... , Dec. 14, 2016 "Increase in mobile ... market" The mobile biometrics market is expected to grow ... billion by 2022, at a CAGR of 29.3% between ... such as the growing demand for smart devices, government ... "Software component is expected to grow at ...
(Date:12/8/2016)...  Singulex, Inc., the leader in Next Generation Immunodiagnostics ... license and supply agreement with Thermo Fisher Scientific, the ... access to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker ... to diagnose systemic bacterial infection and sepsis and in ... in assessing the risk of critically ill patients for ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... Atlas Genetics Ltd., the ultra-rapid Point-Of-Care ... D financing, raising $35 million from a syndicate including all ... ... the Atlas Genetics io® system has been completed with the ... in February 2016.  This new Series D equity issue will ...
(Date:1/21/2017)... ... January 20, 2017 , ... G&L Scientific Inc, a leading ... http://www.gandlscientific.com ), has announced the opening of new offices in Cambridge, Massachusetts, strengthening ... contractors. This is the latest step in G&L’s expansion of its global clinical ...
(Date:1/21/2017)... LEAWOOD, Kan. , Jan. 20, 2017 ... pet therapeutics company focused on the licensing, development and ... Animal Pharm,s Best Company in ... was granted the award based on the ... ® (grapiprant tablets), ENTYCE ® (capromorelin oral ...
(Date:1/20/2017)... http://www.Financialbuzz.com - According ... causes of death worldwide. There were 8.2 million cancer ... related deaths increased gradually over time, the death rates ... various cancers continues to drive demand of biological therapies ... Market Insights, Inc. cancer biological therapy market size was USD ...
Breaking Biology Technology: