Navigation Links
Bladder cells feel stretch

Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki Sokabe (National Institute for Physiological Sciences: NIPS), and Prof. Masayuki Takeda, Dr. Isao Araki and Dr. Tsutomu Mochizuki (Yamanashi Univ.), found that bladder urothelial cells have a sensor for stretch stimulation. Their finding was reported in the Journal of Biological Chemistry published on Aug 7, 2009.

Bladder is known to release ATP that activates micturition reflex pathway during urine storage. However, it has been unknown how urothelial cells sense bladder distension. The research group examined the function of 'TRPV4' protein abundantly expressed in urothelial cells. The group developed a special apparatus to measure cell responses upon stretch stimulation, which mimics bladder distension.

Upon stretch stimulation, robust Ca2+ influx and following ATP release were observed in urothelial cells. These phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.

Dr. Sokabe said, "This is the first report to show that TRPV4 is a primal stretch-detector in urothelial cells. Given that TRPV4 is critically involved in the sensing mechanism in the bladder, development of chemicals modulating TRPV4 activity may be useful for treatment of bladder disorders such as overactive bladder and pollakiuria."


Contact: Takaaki Sokabe
National Institute for Physiological Sciences

Page: 1

Related biology news :

1. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
2. Bacteria that cause urinary tract infections invade bladder cells
3. Extract of broccoli sprouts may protect against bladder cancer
4. Selenium may prevent high risk-bladder cancer
5. Robo-surgery: As safe and capable as a human assistant in key-hole gallbladder removal
6. Chemical in blood may explain susceptibility to bladder pain
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. Newly created cancer stem cells could aid breast cancer research
9. AIDS interferes with stem cells in the brain
10. Clemson scientists shed light on molecules in living cells
11. Social habits of cells may hold key to fighting diseases
Post Your Comments:
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
Breaking Biology Technology: