Navigation Links
Bitterness induces nausea, swallowing not required
Date:4/11/2011

The mere taste of something extremely bittereven if you don't swallow it at allis enough to cause that dreaded feeling of nausea and to set your stomach churning, according to a new study reported in the April 12th issue of Current Biology, a Cell Press publication.

"This work shows that our body and our physiology anticipate the consequences of foods we might eat, even if those foods contain toxins or anti-nutrients," said Paul Breslin of the Monell Chemical Senses Center and Rutgers University.

Of course, it is well known that the promise of something tempting to eat can cause a physiological response. Think Pavlov and his salivating dog. It also seems intuitive that bitterness, a taste associated with most plant-derived toxins, might be linked to nausea. However, Breslin says, the evidence was lacking.

In the current study, Breslin and the study's first author, Catherine Peyrot des Gachons, asked 63 healthy (and brave) individuals to sample an intensely bitter but non-toxic solution. He says the flavor could be compared to a typical concoction of liquid cold and flu medication on the bitterness scale. Participants held the bitter solution in their mouths for 3 minutes before spitting it back out. The experience led most people to report feelings of nausea that were either mild to moderate or strong. A second bitter solution had the same effect on people, unlike sweet, salty, or umami tastes.

During the taste-testing sessions, the researchers also recorded the electrical activity in the stomach using electrodes. Certain irregular patterns of stomach muscle activity are a hallmark of nausea, Breslin explained.

Those results made it clear that the self-reported nausea wasn't all in the study participants' heads. The exposure to bitter solutions produced responses in the stomach that were comparable to those caused by extreme motion sickness, the researchers report.

"It was known that our body can anticipate the ingestion of nutrients and prepare for them," Breslin said. "It was not known if our bodies anticipated the ingestion of toxins or anti-nutrients and prepared for this. Here we show that our bodies punish us for holding strong toxins in the mouth and that our stomachs respond so as to trap them and likely vomit them back up if swallowed."

The findings suggest that those already prone to nauseaincluding pregnant women and patients undergoing chemotherapyshould take particular care to avoid bitter tastes. "In some instances, extreme nausea is worse than extreme pain, and anything we can do to help manage this is important," Breslin said.


'/>"/>

Contact: Elisabeth Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related biology news :

1. Stem-cell disruption induces skull deformity, UR study shows
2. Treatment for extreme nausea, vomiting during pregnancy
3. Caution required for Gulf oil spill clean-up
4. A single atom controls motility required for bacterial infection
5. Identification of a key molecular pathway required for brain neural circuit formation
6. Cell anchors required to prevent muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... Ca (PRWEB) , ... May ... ... (PSCs) offer an unlimited source of human cardiovascular cells for research and ... differentiation methods makes it possible to generate large numbers of cardiomyocytes (hPSC-CMs). ...
(Date:5/23/2017)... MA (PRWEB) , ... May 23, 2017 , ... ... sources for advanced technology applications, has announced a facility expansion to accommodate its ... 3,000 square feet of new workspace and renovation of the existing areas. The ...
(Date:5/22/2017)... MA (PRWEB) , ... May 22, 2017 , ... Stratevi, ... has expanded to the East Coast. It has opened an office in downtown Boston ... therapies are finding it increasingly more important to generate evidence on the value they ...
(Date:5/19/2017)... ... , ... In response to the strong base of evidence supporting the use ... release of their Gait Trainer 3 with an Integrated Music Therapy option. This is ... in rehabilitating individuals with cerebral palsy, traumatic brain injury, stroke and Parkinson’s disease. ...
Breaking Biology Technology: