Navigation Links
Bits of 'junk' RNA aid master tumor-suppressor gene
Date:8/23/2007

portance of messenger RNA (mRNA), which carries protein-making instructions. However, until recently, little was known about micro RNA genes. It is now well recognized that miRNAs regulate the levels of mRNAs, and/or the levels of the proteins produced from mRNAs.

The U-M research team studied the roles of the three genes that make up the miRNA34 family. They showed that the miRNA34 genes work in concert with p53, then went on to explore which other genes the family regulates. They found the miRNA34 genes showed pronounced effects on other genes that control the timing of cell proliferation and division. They also found that the miRNA34 gene family regulated the levels of the Bcl-2 protein, a key factor that enhances a cells resistance to death-inducing stimuli.

The team went on to determine if expression of the miRNA34 genes was compromised in human lung cancer cells.

We found that expression of two of the miRNA34 genes was lost in almost two-thirds of lung adenocarcinomas, says Bommer.

Adenocarcinomas represent the most common type of non-small cell lung cancer, which is the most frequently diagnosed type of lung cancer. When expression of the miRNA34 genes was restored in lung cancer cells, some of the aberrant growth properties were inhibited.

The discoveries of the role of micro RNAs in tumor suppression could have implications for future cancer therapies.

Its important to note that micro RNAs alone are not likely to offer new cancer treatment or prevention agents, says Fearon, who is the Emanual N Maisel Professor of Oncology, Professor of Internal Medicine, Professor of Pathology and Professor of Human Genetics at the U-M Medical School.

However, because of the small size of mature miRNAs, there is optimism that it may be possible to deliver modified nucleic acids that might mimic the effect of the miRNAs, he says. If modified nucleic acids were to prove effective in more laboratory stu
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Seaweed could make junk food healthier
2. Rodent social behavior encoded in junk DNA
3. Junk DNA may not be so junky after all
4. Evolutionary scrap-heap challenge: Antifreeze fish make sense out of junk DNA
5. University of Iowa scientists explore function of junk DNA
6. Master gene controls healing of skin in fruit flies and mammals
7. UT Southwestern researchers discover master switch in cell death
8. Master regulatory gene found that guides fate of blood-producing stem cells
9. Wisconsin scientists discover a master key to microbes pathogenic lifestyles
10. Master genetic switch found for chronic pain
11. Cuttlefish masters of disguise despite colorblindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/17/2015)... BURNABY, Canada , April 17, 2015 /PRNewswire/ ... projects, growing security concerns, and technological advancement to ... Arabia until 2020   ... " Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric ... is projected to register growth at CAGR ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... , AMES, Iowa A research team led by Edward ... discovered the crystal structures of pumps that remove heavy metal ... The findings are published in the Sept. 23 issue of ... State associate professor of chemistry, of physics and astronomy, of ...
... rhino with a ridiculously supersized head." "Fifteen long, pointed sideways ... one at the tip of each cheek bone, and ten across ... large horn over the nose and short, blunt eye horns that ... to describe two newly discovered species of dinosaurs with looks only ...
... This release is available in French . ... of acutely hospitalized patients, according to a study carried out ... affiliated Lady Davis Institute for Medical Research (LDI). In ... randomly assigned to receive either vitamin C or vitamin D ...
Cached Biology News:Iowa State, Ames Lab researchers identify structure that allows bacteria to resist drugs 2New species of multi-horned dinosaurs unearthed in Utah 2Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers 2
(Date:5/29/2015)... -- Asthma treatment could   see ... treatments enter arena, says   GBI Research ... several of the leading asthma brands, such as Advair ... the global market for asthma treatment is set to ...   New analysis from business intelligence provider ...
(Date:5/29/2015)... Pa. (PRWEB) May 29, 2015 ... Product Solutions with a request to design an ... excess moisture from prescription medications being produced using ... solution that includes a robotic gantry, heat-saving windows, ... and dries trays of 3D-printed pills to exact ...
(Date:5/29/2015)... DUBLIN , May 28, 2015 ... the addition of Jain PharmaBiotech,s new report ... their offering. This report deals with ... classical use mainly to describe the chromosome structure ... age of molecular biology, it is also referred ...
(Date:5/29/2015)... Seoul Semiconductor (CEO: Chung-hoon Lee, ... on May 28th announced that it will increase ... its high efficient and high reliable LED product ... Seoul Semiconductor has developed efficient and reliable LED ... supplied LEDs for headlamps to global auto makers. ...
Breaking Biology Technology:Personalized Treatment for Severe Asthma to Drive Market Growth Despite Patent Expirations 2Personalized Treatment for Severe Asthma to Drive Market Growth Despite Patent Expirations 3New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3Seoul Semiconductor Increases the Global Automotive LED Market Share with its High Efficient and Reliable LEDs for Automotive Lightings 2
... is collaborating with the National Cancer Institute,s Nanotechnology Characterization ... of a nanotechnology-based gene therapy for brain cancer. ... nanoparticles for effective delivery to the tumor site -- ... clinical trials in patients with colorectal and ovarian cancers. ...
... solutions to human energy demands are essential to our future. ... our disposal, we have yet to learn how to capture, ... of Toronto chemistry professor Greg Scholes, the answers can be ... "Solar fuel production often starts with the energy from light ...
... announced that it is providing $70 million in debt ... that includes a new seven-story 89,700-square-foot research tower above ... in University City. The expansion will enable ... particularly cancer research and vaccine development – to expand ...
Cached Biology Technology:EGEN, Inc. Collaborates With Nanotechnology Characterization Laboratory on Brain Cancer Therapy 2EGEN, Inc. Collaborates With Nanotechnology Characterization Laboratory on Brain Cancer Therapy 3Nature offers key lessons on harvesting solar power, says U of T chemistry professor 2Citizens Bank Provides $70 Million in Financing Toward $100 Million Expansion of The Wistar Institute 2
... by A300-183A maps to the ... human quaking homolog according to ... The epitope is not found ... 4, 6, 7 or 7B ...
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
...
... [198C679.2.1] to Presenilin 2 Alzheimer's disease ... the disease carry mutations in the presenilin ... protein (APP). These disease-linked mutations result in ... amyloid-beta (main component of amyloid deposits found ...
Biology Products: