Navigation Links
Bits of 'junk' RNA aid master tumor-suppressor gene
Date:8/23/2007

Little-known bits of RNA help master tumor-suppressor gene do its job, U-M cancer researchers find

Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer

ANN ARBOR, Mich. Scientists have shown in literally thousands of studies that the p53 gene deserves its reputation as the guardian of the genome. It calls to action an army of other genes in the setting of varied cell stresses, permitting repair of damaged DNA or promoting cell death when the cell damage is too great. A key net effect of p53s action is to prevent development of cancerous cells.

Now, University of Michigan Medical School scientists provide the most thorough evidence yet that p53 also regulates a trio of genes from the realm of so-called junk genes the roughly 97 percent of a cells genetic material whose function is only beginning to be understood.

The study shows that in the junk lies treasure, in terms of critical knowledge about how normal cells stifle cancer or succumb to it, says Guido Bommer, M.D., the lead author of results, published in a recent issue of the journal Current Biology.

The findings in the study offer new insights into specific mechanisms by which the expression of hundreds to thousands of genes and proteins is altered in the roughly 50 percent of cancers that carry mutations in the p53 tumor suppressor gene, says Eric Fearon, M.D., Ph.D., senior author of the study and deputy director of the U-M Comprehensive Cancer Center. Scientists continue to mine for details of what goes wrong when p53 is defective and cannot perform its tumor-fighting duties.

The U-M study is one of four recent studies from labs around the world showing that p53 normally gets support from members of a small family of micro RNA genes. The studies are part of a larger effort to understand the function of micro RNA (miRNA for short).

Scientists have long known the im
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Seaweed could make junk food healthier
2. Rodent social behavior encoded in junk DNA
3. Junk DNA may not be so junky after all
4. Evolutionary scrap-heap challenge: Antifreeze fish make sense out of junk DNA
5. University of Iowa scientists explore function of junk DNA
6. Master gene controls healing of skin in fruit flies and mammals
7. UT Southwestern researchers discover master switch in cell death
8. Master regulatory gene found that guides fate of blood-producing stem cells
9. Wisconsin scientists discover a master key to microbes pathogenic lifestyles
10. Master genetic switch found for chronic pain
11. Cuttlefish masters of disguise despite colorblindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... , Oct. 20, 2014  Leading identity analyst firm ... half of the world,s population will have a chip-based ... Europe . Asia , ... market accounting for more than 60% of all National ... Acuity,s report  -- "The Global National eID ...
(Date:10/18/2014)... for evaluation of suspected genetic conditions, whole-exome sequencing ... including detection of a number of rare genetic ... to a study appearing in JAMA . ... the American Society of Human Genetics annual meeting. ... regions of thousands of genes simultaneously using next-generation ...
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... Torriani is a plant pathologist. His most recent research ... where he analyzed a special class of genes that ... heavily on these enzymes when attacking a plant. But ... one gene came in different sizes in different individuals. ...
... A team of scientists from Worcester Polytechnic Institute ... Life Sciences and Bioengineering Center, have regenerated functional muscle ... clinical therapy to treat people who suffer major muscle ... coax mature human muscle cells into a stem cell-like ...
... Adelaide scientist says much more could be done to predict ... tuberculosis (TB) or foot-and-mouth disease - in Australian wildlife and ... have evaluated freely available software tools that provide a realistic ... used a combination of models to look at the possible ...
Cached Biology News:Shedding light on the 'dark matter' of the genome 2Shedding light on the 'dark matter' of the genome 3Shedding light on the 'dark matter' of the genome 4Body rebuilding: Researchers regenerate muscle in mice 2Body rebuilding: Researchers regenerate muscle in mice 3New thinking required on wildlife disease 2
(Date:10/22/2014)... BOSTON , Oct. 22, 2014 /PRNewswire/ ... global specialty pharmaceutical company, and Rhythm, a biopharmaceutical company, ... option to acquire Rhythm,s wholly owned subsidiary, Rhythm Health, ... agonist, for the treatment of diabetic gastroparesis and other ... a successful Phase 2 trial of relamorelin for the ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider ... with a team of researchers from Yale University’s School ... Collaborative to provide electronic questionnaire data collection through use ... started in May, aims to evaluate the impact of ... to and participation in urban agriculture to impact their ...
(Date:10/22/2014)... Oct. 22, 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, announced today that ... Notice of Allowance for a composition of matter patent ... difficile program, SYN-004. This is Synthetic Biologics, first ... U.S. and adds to the Company,s extensive C. ...
(Date:10/20/2014)... 2014 The report “Pharmacy Automation ... Packaging and Labeling Systems, Table-top Counters) by End-user ... Forecasts & Trends to 2019” analyzes and studies ... North America, Europe, Asia-Pacific, and the Rest of ... and 30 figures spread through 300 pages and ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... , , , , , ... , , , , The ability ... means that trace amounts of DNA contaminants could serve as templates, resulting , ... mentioned below to avoid PCR contamination from sources such as: , ...
... , , , , , , ... are three types of primers that may be used for reverse transcription: , ... poly(A) + tail , at the 3' end of mammalian mRNA. ... , Random hexanucleotides, which bind ...
... , , , ... a billionfold. Thus, even minuscule amounts of a contaminant can ... positive result. Such contaminants are often products , ... researchers have developed methods to avoid such contamination. , ...
Cached Biology Technology:Setting up the laboratory to avoid contamination 2Preventing Carry-over Contamination with Uracil-DNA Glycosylase 2
Human GCP-2 is a member of the CXC family of chemokines. It also promotes neutrophil chemotaxis and deganulation. GF063 is an 8.0 kDa protein containing 73 amino acid residues....
... Gel Loading Buffer contains a precipitant to ... and a tracking dye to allow the user ... Components ReddyRun™: ABgene ® s ... with the same buffer composition used in ReddyRun™ ...
... CLS number is a ... to easily match Cornings ... no availability yet, please ... Sigma-Aldrich number (Z71,381-3) or ...
Excellent safety and durability., Remote control can be easily operated in your hand., Constant voltage control with 2 sets of terminals., Precise and durable circuit design. ...
Biology Products: