Navigation Links
Bisphenol A exposure in pregnant mice permanently changes DNA of offspring
Date:6/10/2009

Exposure during pregnancy to the chemical bisphenol A, or BPA, found in many common plastic household items, is known to cause a fertility defect in the mother's offspring in animal studies, and now researchers have found how the defect occurs. The results of the new study will be presented Saturday at The Endocrine Society's 91st Annual Meeting in Washington, D.C.

The study, funded partly by the National Institutes of Health, joins a growing body of animal research showing the toxic health effects of BPA, including reproductive and developmental problems. Last August the U.S. Food and Drug Administration found BPA to be safe as currently used but later said more research on its safety is needed. BPA is used to make hard polycarbonate plastic, such as for baby bottles, refillable water bottles and food containers, as well as to make the linings of metal food cans.

BPA has estrogen-like properties and in pregnant animals has been linked to female infertility.

"The big mystery is how does exposure to this estrogen-like substance during a brief period in pregnancy lead to a change in uterine function," said study co-author Hugh Taylor, MD, professor and chief of the reproductive endocrinology section at Yale University School of Medicine.

To find the answer to that question, Taylor and his co-workers at Yale injected pregnant mice with a low dose of BPA on pregnancy days 9 to 16. After the mice gave birth, the scientists analyzed the uterus of female offspring and extracted DNA.

They found that BPA exposure during pregnancy had a lasting effect on one of the genes that is responsible for uterine development and subsequent fertility in both mice and humans (HOXA10). Furthermore, these changes in the offspring's uterine DNA resulted in a permanent increase in estrogen sensitivity. The authors believe that this process causes the overexpression of the HOXA10 gene in adult mice that they found in previous studies.

The permanent DNA changes in the BPA-exposed offspring were not apparent in the offspring of mice that did not receive BPA injection (the controls). This finding demonstrates that the fetus is sensitive to BPA in mice and likely also in humans, Taylor said.

"We don't know what a safe level of BPA is, so pregnant women should avoid BPA exposure," Taylor said. "There is nothing to lose by avoiding items made with BPAand maybe a lot to gain."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related biology news :

1. Bisphenol A linked to metabolic syndrome in human tissue
2. NTP finalizes report on Bisphenol A
3. Environmental exposures may damage DNA in as few as three days
4. Agent Orange exposure increases veterans risk of aggressive recurrence of prostate cancer
5. Lab study shows THC exposure as adolescents linked to negative effects of THC as adults
6. Prenatal meth exposure linked to abnormal brain development
7. Exposure to insecticide may play role in obesity epidemic among some women
8. How increased UV exposure impacts plants
9. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
10. Novel technique changes lymph node biopsy, reduces radiation exposure
11. Novel technique changes lymph node biopsy, reduces radiaiton exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... ... The AMA is happy to announce that $48,000 in scholarships will be ... are created through funds donated by model aviation organizations and individuals, AMA members, and ... Scholarship Committee, which is made up of model aviation pilots and enthusiasts. The committee ...
(Date:4/20/2017)... Austin, TX; Ultrecht, Netherlands (PRWEB) , ... April ... ... Qafis Biometrics Technology today announced their strategic partnership to offer a ... Qafis’ digital identity authentication, a comprehensive suite of biometric products and the ground-breaking ...
(Date:4/20/2017)... (PRWEB) , ... April 20, 2017 , ... NetDimensions appoints ... Sales. , With over 20 years of experience in the learning technologies industry, Mastin ... sister company within Learning Technologies Group plc (LTG). At LEO, Mastin served as SVP ...
(Date:4/20/2017)... , ... April 20, 2017 , ... ... of a unique intellectual property (IP) sharing and commercialization model. , The Center ... inventions. A main component of this effort is bringing the IP to the ...
Breaking Biology Technology: