Navigation Links
Bird flu vaccine protects people and pets
Date:10/19/2008

A single vaccine could be used to protect chickens, cats and humans against deadly flu pandemics, according to an article published in the November issue of the Journal of General Virology. The vaccine protects birds and mammals against different flu strains and can even be given to birds while they are still in their eggs, allowing the mass vaccination of wild birds.

The emergence of bird flu has posed a major challenge to scientists designing vaccines as it can infect a number of different animals, including birds, pets and people. Now, researchers in the USA have discovered that a vaccine based on a bird flu virus could be used to protect several species against different influenza viruses.

"The world is experiencing a pandemic of influenza in birds caused by an H5N1 virus. Although it has been restricted to Eurasia and some countries in Africa, there is a risk that this virus may spread worldwide," said Professor Daniel Perez from the University of Maryland, USA. "The H5N1 virus also has an unusual expanded host range: not only birds and humans have been infected but also cats, which are usually resistant to influenza. To prepare for a pandemic, it would be ideal to have a vaccine that could be used in multiple animal species."

The researchers found that the central genes or 'backbone' of the H9N2 virus that infects guinea fowl can protect birds and mice against highly pathogenic strains of influenza. They modified the virus to make it less pathogenic and then used it to vaccinate mice. Three weeks after being vaccinated, the mice were infected with the potentially lethal H1N1 virus the same virus that caused the 1918 Spanish flu pandemic. All the vaccinated mice survived with no signs of disease. Vaccinated mice also survived infection with the deadly H5N1 bird flu virus, again showing no signs of disease.

"Our results show that the H9N2 backbone vaccine can be used to protect mice against two different, highly pathogenic strains of influenza. We chose genes from H9N2 influenza for the vaccine because the virus can infect many different animals, including chickens, mice and pigs," said Professor Perez. "A very important limitation in the current design of flu vaccines is that they are usually species specific. Our approach involves a universal backbone that can be used in several different species, including humans."

More importantly, this live attenuated virus provided effective protection when it was administered to birds before they had hatched. By vaccinating eggs against influenza, we could protect wild bird species as well as domestic chickens against pandemic flu strains, limiting the spread of disease to humans.

"If an emerging strain of bird flu spreads among a broad range of animal species, we should expect major health, economic and ecological consequences," said Professor Perez. "It is unrealistic to consider preparing different vaccines specifically tailored to different animal species in this situation. An influenza vaccine that could protect different species would save valuable time during a pandemic."


'/>"/>

Contact: Lucy Goodchild
press@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. RNA molecules, delivery system improve vaccine responses, effectiveness
2. Childrens National researchers develop novel anti-tumor vaccine
3. Vaccine against HER2-positive breast cancer offers complete protection in lab
4. Clinical trial for new tuberculosis vaccine
5. Syracuse University partners with Serum Institute of India to develop vaccines for children
6. Nano vaccine for hepatitis B shows promise for third world
7. UCF professor develops vaccine to protect against black plague bioterror attack
8. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
9. Prostate cancer vaccines more effective with hormone therapy
10. From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
11. Footrot vaccine closer than ever
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... New York , March 15, 2016 ... new market report published by Transparency Market Research "Digital Door ... Trends and Forecast 2015 - 2023," the global digital door ... US$ 731.9 Mn in 2014 and is forecast to grow ... 2023. Growth of micro, small and medium enterprises (MSMEs) across ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... Images ( http://www.apimages.com ) - Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ... Hanover next week.   --> Germany ... the new refugee identity cards. DERMALOG will be unveiling this device, ...
(Date:3/9/2016)... NEW YORK , March 9, 2016 ... current and future states of the RNA Sequencing (RNA ... in segments such as instruments, tools and reagents, data ... Analyze various segments of the RNA-Sequencing market such ... RNA-Sequencing services Identify the main factors affecting each segment ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... 2016 , ... The need for blood donations in South Texas and across the nation is ... & Tissue Center, blood donations are on the decline. In fact, donations across the country ... percent in South Texas in the last four years alone. , There is no substitute ...
(Date:5/23/2016)... Ind. , May 23, 2016 Zimmer Biomet ... musculoskeletal healthcare, today announced that its Board of Directors has ... for the second quarter of 2016. The ... or about July 29, 2016 to stockholders of record as ... declarations of dividends are subject to approval of the Board ...
(Date:5/23/2016)... May 23, 2016 - Leading CRO,s Use ... - Frontage Implement a Single Platform to Manage End-to-end Operations ... Within the Bioanalytical lab Frontage Laboratories, a full-service contract ... and China , has selected IDBS, ... In addition to serving as the global electronic lab notebook (ELN), ...
(Date:5/23/2016)... ... May 23, 2016 , ... Foresight Institute ... announced the winners for the 2015 Foresight Institute Feynman Prizes. , These ... two categories, one for experiment and the other for theory in nanotechnology. Prof. ...
Breaking Biology Technology: