Navigation Links
Bird flu leaves the nest -- adapting to a new host
Date:8/26/2009

Hamburg, Germany Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al, "Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus" appears in the September 2009 issue of the American Journal of Pathology.

Highly pathogenic avian influenza, commonly known as bird flu, is a strain of the influenza virus that has adapted to infect birds. Although bird-specific flu strains rarely cross species, further adaption can lead to lethal infection in humans.

To determine which genetic changes may lead to host adaptation, Glsah Gabriel (currently at the Heinrich-Pette-Institute for Experimental Virology and Immunology the University of Hamburg) and Hans-Dieter Klenk at the Institute of Virology at the Philipps University of Marburg examined two strains of avian influenza, an unadapted avian strain and an avian strain adapted to infect mice by mutations that increase the efficiency of the viral polymerase. They found that whereas the avian strain only infected the lungs, the mouse-adapted strain caused suppression of the immune system, which resulted in infection in multiple organs. In addition, while the avian strain caused only mild symptoms in mice, the mouse-adapted strain led to severe illness including pneumonia and infection of the brain, followed by death. The viral polymerase may therefore provide an important target in preventing systemic flu in humans.

Gabriel et al suggest that "reduction of high virus loads by targeting the viral polymerase may play an important role in the treatment of human influenza with systemic virus spread." In future studies, Dr. Gabriel and colleagues will aim to develop drugs interfering with virus polymerase activity.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Why are autumn leaves red in America and yellow in Europe?
2. The hepatitis healing power of blueberry leaves
3. A win-win: U-pick pumpkin farms recycle urban leaves
4. When leaves fall, more is occurring than a change of weather
5. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
6. Aquaculture concept leaves judges goggle eyed
7. Why do autumn leaves bother to turn red?
8. Most US organizations not adapting to climate change
9. Report -- adapting farming to climate change
10. Adapting local ecosystems can soften impact of global climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
Breaking Biology News(10 mins):
(Date:7/25/2017)... ... July 25, 2017 , ... ... Strategic Planning. His extensive background in consulting, development and marketing make him ... and differentiation consulting, business strategy development, new product marketing and global commercial ...
(Date:7/24/2017)... New Jersey (PRWEB) , ... July 24, 2017 ... ... staffing firms across the US and Canada who have proven their superior service ... assessment, Inavero identified Spearhead Staffing as an industry leader based on service quality ...
(Date:7/20/2017)... ... July 20, 2017 , ... Dr. Asher Kimchi, Founder and Chairman of ... 2017 IAC Awards at the 22nd World Congress on Heart Disease held in Vancouver, ... to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. ...
(Date:7/20/2017)... July 20, 2017   KCNQ2 Cure Alliance ... evaluations company, today announced that they have completed ... genetic mutation implicated in KCNQ2 epileptic encephalopathy. They ... a second case involving an additional KCNQ2 genetic ... Alliance and Pairnomix entered into a collaboration to ...
Breaking Biology Technology: