Navigation Links
Bird flu leaves the nest -- adapting to a new host
Date:8/26/2009

Hamburg, Germany Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al, "Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus" appears in the September 2009 issue of the American Journal of Pathology.

Highly pathogenic avian influenza, commonly known as bird flu, is a strain of the influenza virus that has adapted to infect birds. Although bird-specific flu strains rarely cross species, further adaption can lead to lethal infection in humans.

To determine which genetic changes may lead to host adaptation, Glsah Gabriel (currently at the Heinrich-Pette-Institute for Experimental Virology and Immunology the University of Hamburg) and Hans-Dieter Klenk at the Institute of Virology at the Philipps University of Marburg examined two strains of avian influenza, an unadapted avian strain and an avian strain adapted to infect mice by mutations that increase the efficiency of the viral polymerase. They found that whereas the avian strain only infected the lungs, the mouse-adapted strain caused suppression of the immune system, which resulted in infection in multiple organs. In addition, while the avian strain caused only mild symptoms in mice, the mouse-adapted strain led to severe illness including pneumonia and infection of the brain, followed by death. The viral polymerase may therefore provide an important target in preventing systemic flu in humans.

Gabriel et al suggest that "reduction of high virus loads by targeting the viral polymerase may play an important role in the treatment of human influenza with systemic virus spread." In future studies, Dr. Gabriel and colleagues will aim to develop drugs interfering with virus polymerase activity.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Why are autumn leaves red in America and yellow in Europe?
2. The hepatitis healing power of blueberry leaves
3. A win-win: U-pick pumpkin farms recycle urban leaves
4. When leaves fall, more is occurring than a change of weather
5. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
6. Aquaculture concept leaves judges goggle eyed
7. Why do autumn leaves bother to turn red?
8. Most US organizations not adapting to climate change
9. Report -- adapting farming to climate change
10. Adapting local ecosystems can soften impact of global climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency is insourcing ... prevent counterfeit microcircuits from entering into its supply chain. ... microcircuit anti-counterfeit initiative dubbed DNA marking. The capability will ... reliability throughout the supply chain. The new quality control ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally transforming the ... at international borders. Over the past decade, ePassports, biometric ... to self process through border control via eGates and ... of airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... -- Studies in recent years have demonstrated that binge ... the risk of osteoporosis. Now a Loyola University ... mechanism: Alcohol disturbs genes necessary for maintaining healthy bones. ... new drugs to minimize bone loss in alcohol abusers. ...
... Zecure, a leading,provider of e-commerce fraud ... installed its award-winning Acquirer SAFE suite to,prevent ... to keep,high risk merchants under control., ... Service Providers,(PSPs) keep high-risk merchants under control ...
... along with colleagues from the California Institute of Technology, ... institutions, have unearthed crystalline magnetic fossils of a previously ... of the Paleocene and Eocene epochs, some 55 million ... the Proceedings of the National Academy of Sciences ...
Cached Biology News:Why binge drinking is bad for your bones 2OrbitalPay, LLC Implements Zecure's Acquirer SAFE Solution to Stop Fraudulent E-Commerce Merchants 2Earlier global warming produced a whole new form of life 2
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
(Date:12/24/2014)... On Friday, December 19, 2014, President Obama ... Resolution Appropriations Act of 2015, which for the first ... through the Congressionally Directed Medical Research Programs (CDMRP) administered ... (HA), working in conjunction with its allies on Capitol ...
(Date:12/24/2014)... 23, 2014 The report provides ... definition, classification, application and industry overview. This report ... cost structure. Production is separated by regions, technology ... materials, equipment, downstream client survey, marketing channels, industry ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... Madison, Wis. - It may not rank with the ... Bachelor , but a Madison-based online service is doing a ... service that matches privately held companies with board candidates, has thus ... tempted to veer into another lane on the information super highway. ...
... has been awarded a $2 million grant from the ... of Energy to develop its method of converting glycerol, ... propylene glycol. , ,The grant was awarded as part of ... which was established to develop of technologies that make bio-based ...
... The Center for Advanced Technology and Innovation , a ... commercial life into unused and underused technologies, is taking ... ,If successful at facilitating the launch of new products ... in Wisconsin and elsewhere while building connections for further ...
Cached Biology Technology:Online service makes board connections 2Online service makes board connections 3Virent lands $2M grant for chemical production 2CATI takes tech transfer model national 2CATI takes tech transfer model national 3
Rabbit polyclonal to Streptococcus Enterotoxin C ( Abpromise for all tested applications)....
... which can immunocapture up to 50 g ... included are 2 mg of bovine heart ... immunocapture kit allows isolation of the ATP ... of tissue. This facilitates subsequent analysis of ...
Anti-ADAM-12 (Meltrin Alpha); carboxy terminal end; rabbit host...
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
Biology Products: