Navigation Links
Bird flu leaves the nest -- adapting to a new host
Date:8/26/2009

Hamburg, Germany Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al, "Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus" appears in the September 2009 issue of the American Journal of Pathology.

Highly pathogenic avian influenza, commonly known as bird flu, is a strain of the influenza virus that has adapted to infect birds. Although bird-specific flu strains rarely cross species, further adaption can lead to lethal infection in humans.

To determine which genetic changes may lead to host adaptation, Glsah Gabriel (currently at the Heinrich-Pette-Institute for Experimental Virology and Immunology the University of Hamburg) and Hans-Dieter Klenk at the Institute of Virology at the Philipps University of Marburg examined two strains of avian influenza, an unadapted avian strain and an avian strain adapted to infect mice by mutations that increase the efficiency of the viral polymerase. They found that whereas the avian strain only infected the lungs, the mouse-adapted strain caused suppression of the immune system, which resulted in infection in multiple organs. In addition, while the avian strain caused only mild symptoms in mice, the mouse-adapted strain led to severe illness including pneumonia and infection of the brain, followed by death. The viral polymerase may therefore provide an important target in preventing systemic flu in humans.

Gabriel et al suggest that "reduction of high virus loads by targeting the viral polymerase may play an important role in the treatment of human influenza with systemic virus spread." In future studies, Dr. Gabriel and colleagues will aim to develop drugs interfering with virus polymerase activity.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Why are autumn leaves red in America and yellow in Europe?
2. The hepatitis healing power of blueberry leaves
3. A win-win: U-pick pumpkin farms recycle urban leaves
4. When leaves fall, more is occurring than a change of weather
5. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
6. Aquaculture concept leaves judges goggle eyed
7. Why do autumn leaves bother to turn red?
8. Most US organizations not adapting to climate change
9. Report -- adapting farming to climate change
10. Adapting local ecosystems can soften impact of global climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2016)... Nov. 21, 2016   Neurotechnology , a ... technologies, today announced that the MegaMatcher On Card ... submitted for the NIST Minutiae Interoperability Exchange ... the mandatory steps of the evaluation protocol. ... continuing test of fingerprint templates used to establish ...
(Date:11/15/2016)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... gut microbiome, today announced the pricing of an ... common stock and warrants to purchase 50,000,000 shares ... the public of $1.00 per share and accompanying ... offering, excluding the proceeds, if any from the ...
(Date:6/22/2016)... -- The American College of Medical Genetics and Genomics was once ... one of the fastest-growing trade shows during the Fastest 50 ... Las Vegas . Winners ... each of the following categories: net square feet of paid ... The 2015 ACMG Annual Meeting was ranked 23 out of ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... Georgia (PRWEB) , ... December 05, 2016 , ... ... lignin-coated nanocellulose, including both cellulose nanocrystals and cellulose nanofibrils. The composition claims ... There are also claims directed to combination with polymers, carbon fibers, graphene, ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... to soon resume cervical and lumbar disc production, company President, Jake Lubinski will ... who are implanting the AxioMed disc in Cologne and Karlsruhe to discuss the ...
(Date:12/5/2016)... - Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) ... Monitoring Board (DSMB) for the Company,s Phase 3 ... has completed a second planned safety review and ... without any modifications. The DSMB reviewed available study ... concerns were identified. The DSMB will conduct additional ...
(Date:12/5/2016)... Research and Markets has announced the addition of Jain ... Companies" to their offering. ... , , ... development of sequencing technologies, and their applications. Current large and ... Various applications of sequencing are described including those for genetics, ...
Breaking Biology Technology: