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Biosynthetics production with detours
Date:10/31/2008

equently do not know what the individual genes mean and how their interaction functions", says Martins dos Santos. Based on computer models and knowledge from databases, the researchers created a network of individual genes and metabolic processes in P. putida. "All of this is similar to a map with cities and motorways", say, Jacek Puchałka, a colleague in Martins dos Santos' working group. "On some roads, there is a great deal of traffic, while others are very quiet. Some roads are blocked and then there are detours. The metabolic paths in P. putida behave in exactly the same way."

The researchers took advantage of the ability of bacteria to divert their metabolic paths, if a path is disrupted by mutations. The computer model shows which paths need to be changed in P. putida, in order to increase the yield of PHB. This is important for industry: Currently, the production of PHB is still very long and drawn-out and really not justifiable against the oil-based synthetics. "In future, it will be possible to manufacture biosynthetics more efficiently in large quantities. An if we have made our contribution to this, we are very pleased", says Puchałka.


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Contact: Hannes Schlender
presse@helmholtz-hzi.de
49-053-161-811-400
Helmholtz Association of German Research Centres
Source:Eurekalert

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