Navigation Links
Biosynthetics production with detours
Date:10/31/2008

Scientists at the Helmholtz-Zentrum fr Infektionsforschung (HZI) in Braunschweig, Germany have achieved an important advance in better understanding metabolic pathways in bacteria and their use. Using computer models, the "System and Synthetic Biology" working group, headed up by Vtor Martins dos Santos, calculated the genetic changes that are necessary for increasing the production of biosynthetics in the Pseudomonas putida bacteria. Experiments in the laboratory subsequently confirmed the results. With this, the creation of natural synthetics could be increased in a targeted manner in the future. The well-known science magazine, "PLoS Computational Biology" published the results today.

Pseudonomads are bacteria that occur everywhere in our environment. Their changeable and flexible metabolism makes it possible for them to live in different habitats, in water, in soil, on plants and in animals. Among these pseudonomads, there are exponents that can be used in biotechnology. These include Pseudomonas putida: It produces chemicals, pharmaceutical products, degrades waste and toxins. It also plays an important role in manufacturing high-quality substances for industry.

Now, in cooperation with a working group at the Virginia University in America, the researchers working with Martins dos Santos searched for possibilities of increasing the production of natural materials in P. putida. For this, they chose the chemical compound, polyhydroxy butanoic acid (PHB): It is one of the important biosynthetics, which could play a major role in medicine and industry in the future. From it, seam materials, screws, adhesives or implants can be created, which dissolve after an operation or biodegradable packaging. In order to increase the yield of PHB in P. putida, the researchers developed a mathematical model.

However, the path toward such a model is long and drawn-out. "When sequencing the genome of an organism, you frequently do not know what the individual genes mean and how their interaction functions", says Martins dos Santos. Based on computer models and knowledge from databases, the researchers created a network of individual genes and metabolic processes in P. putida. "All of this is similar to a map with cities and motorways", say, Jacek Puchałka, a colleague in Martins dos Santos' working group. "On some roads, there is a great deal of traffic, while others are very quiet. Some roads are blocked and then there are detours. The metabolic paths in P. putida behave in exactly the same way."

The researchers took advantage of the ability of bacteria to divert their metabolic paths, if a path is disrupted by mutations. The computer model shows which paths need to be changed in P. putida, in order to increase the yield of PHB. This is important for industry: Currently, the production of PHB is still very long and drawn-out and really not justifiable against the oil-based synthetics. "In future, it will be possible to manufacture biosynthetics more efficiently in large quantities. An if we have made our contribution to this, we are very pleased", says Puchałka.


'/>"/>

Contact: Hannes Schlender
presse@helmholtz-hzi.de
49-053-161-811-400
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. The 5 Ws of corn production
3. Low oxygen in coastal waters impairs fish reproduction
4. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
5. Curbing C. difficiles toxin production
6. Neuronal conduction of excitation without action potentials based on ceramide production
7. Simulating kernel production influences maize model accuracy
8. Botched production of insulin molecule may lead to diabetes
9. Salmonid hatcheries cause stunning loss of reproduction
10. Increase in ethanol production from corn could significantly impact
11. New evidence for female control in reproduction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... -- Singulex, Inc., the leader in Next Generation Immunodiagnostics powered ... and supply agreement with Thermo Fisher Scientific, the world ... to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker which, ... diagnose systemic bacterial infection and sepsis and in ... assessing the risk of critically ill patients for progression ...
(Date:12/7/2016)... , Dec. 7, 2016   Veridium ... announced the appointment of new CEO James ... executive with decades of experience, has served in ... Cisco, where he specialized in expanding a pipeline ... technology portfolios. He most recently served as managing ...
(Date:12/5/2016)... 5, 2016  The Office of Justice Programs, ... CT Scans Enhance or Replace Medico Legal Autopsies?" ... supporting or replacing forensic autopsies with postmortem X-ray ... In response to recommendations made by The ... CT scans as a potential component of medicolegal ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 This report analyzes the ... Segments: Acid Based (Humic, Amino, & Fulvic), Extract Based, and ... following Crop Types: Ornamental & Turf, Row Crops, and Others. ... Canada , Japan , ... Latin America , and Rest of World. Annual ...
(Date:12/8/2016)... ... December 08, 2016 , ... From wearable devices ... taking over sports. On Thursday, December 15th a panel of entrepreneurs, innovators and ... playing field at a Smart Talk session. Smart Talk will run from 8:30 ...
(Date:12/8/2016)... 8, 2016  Renova™ Therapeutics, a biotechnology company ... and type 2 diabetes, announced that it has ... virus (AAV) vector developed in the laboratory of ... Stanford University. The company plans to use this ... product pipeline. "Early research has ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... that provide essential device-to-computer interconnect using USB or PCI Express, announced the FOMD-ACV-A4, ... The FOMD-ACV-A4 is a small, thin, SODIMM-style module that fits a standard 204-pin ...
Breaking Biology Technology: