Navigation Links
Biosynthetics production with detours
Date:10/31/2008

Scientists at the Helmholtz-Zentrum fr Infektionsforschung (HZI) in Braunschweig, Germany have achieved an important advance in better understanding metabolic pathways in bacteria and their use. Using computer models, the "System and Synthetic Biology" working group, headed up by Vtor Martins dos Santos, calculated the genetic changes that are necessary for increasing the production of biosynthetics in the Pseudomonas putida bacteria. Experiments in the laboratory subsequently confirmed the results. With this, the creation of natural synthetics could be increased in a targeted manner in the future. The well-known science magazine, "PLoS Computational Biology" published the results today.

Pseudonomads are bacteria that occur everywhere in our environment. Their changeable and flexible metabolism makes it possible for them to live in different habitats, in water, in soil, on plants and in animals. Among these pseudonomads, there are exponents that can be used in biotechnology. These include Pseudomonas putida: It produces chemicals, pharmaceutical products, degrades waste and toxins. It also plays an important role in manufacturing high-quality substances for industry.

Now, in cooperation with a working group at the Virginia University in America, the researchers working with Martins dos Santos searched for possibilities of increasing the production of natural materials in P. putida. For this, they chose the chemical compound, polyhydroxy butanoic acid (PHB): It is one of the important biosynthetics, which could play a major role in medicine and industry in the future. From it, seam materials, screws, adhesives or implants can be created, which dissolve after an operation or biodegradable packaging. In order to increase the yield of PHB in P. putida, the researchers developed a mathematical model.

However, the path toward such a model is long and drawn-out. "When sequencing the genome of an organism, you frequently do not know what the individual genes mean and how their interaction functions", says Martins dos Santos. Based on computer models and knowledge from databases, the researchers created a network of individual genes and metabolic processes in P. putida. "All of this is similar to a map with cities and motorways", say, Jacek Puchałka, a colleague in Martins dos Santos' working group. "On some roads, there is a great deal of traffic, while others are very quiet. Some roads are blocked and then there are detours. The metabolic paths in P. putida behave in exactly the same way."

The researchers took advantage of the ability of bacteria to divert their metabolic paths, if a path is disrupted by mutations. The computer model shows which paths need to be changed in P. putida, in order to increase the yield of PHB. This is important for industry: Currently, the production of PHB is still very long and drawn-out and really not justifiable against the oil-based synthetics. "In future, it will be possible to manufacture biosynthetics more efficiently in large quantities. An if we have made our contribution to this, we are very pleased", says Puchałka.


'/>"/>

Contact: Hannes Schlender
presse@helmholtz-hzi.de
49-053-161-811-400
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. The 5 Ws of corn production
3. Low oxygen in coastal waters impairs fish reproduction
4. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
5. Curbing C. difficiles toxin production
6. Neuronal conduction of excitation without action potentials based on ceramide production
7. Simulating kernel production influences maize model accuracy
8. Botched production of insulin molecule may lead to diabetes
9. Salmonid hatcheries cause stunning loss of reproduction
10. Increase in ethanol production from corn could significantly impact
11. New evidence for female control in reproduction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
(Date:4/28/2016)... , April 28, 2016 Infosys ... (NYSE: INFY ), and Samsung SDS, a global ... that will provide end customers with a more secure, fast ...      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... but it also plays a fundamental part in enabling and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: