Navigation Links
Bionanomachines -- proteins as resistance fighters
Date:8/14/2009

A Dresden research team used laser tweezers to measure the friction between a single motor protein molecule and its track. The team found that also within our cells, motors work against the resistance of friction and are restrained in its operationusually by far not as much though as their macroscopic counterparts. These first experimental measurements of protein friction could help researchers to better understand key cellular processes such as cell division which is driven by such molecular machines.

Friction is the force that resists the relative motion of two bodies in contact. The same is true on the nanoscale: Molecular motors have to fight the friction created between them and their tracks. However, since the frictional forces acting on such motors had not been measured before, it was not known how they depend on the speed and the direction of motion.

Friction Slows Down Proteins

Scientists in Dresden at the Biotechnology Center (BIO-TEC) of the Technical University of Dresden and at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) immobilized the molecular motor kinesin on a microsphere which was held by laser tweezers and dragged over its track, a so-called microtubule. In this manner, the friction force between the motor and its microtubule track was measured very precisely. "Just like for macroscopic machines, protein friction limits the speed and efficiency of the small bio-motors", says Erik Schffer, group leader at the BIOTEC and Jonathon Howard, director and group leader at the MPI-CBG.

The researchers explain that the protein, in the absence of an energy source, takes eight nanometer (a millionth of a millimeter) wide "diffusive hops", corresponding to the length of the tubulin subunits that make up a microtubule. The motors step from one tubulin subunit to the adjacent one by forming a new bond with the microtubule filament as another bond is broken. When pulled by the tweezers, the
'/>"/>

Contact: Florian Frisch
frisch@mpi-cbg.de
49-035-121-02840
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. Proteins in gel
2. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
3. TRAPping proteins that work together inside living cells
4. Pliable proteins keep photosynthesis on the light path
5. Autopilot guides proteins in brain
6. New method for detection of phosphoproteins reveals regulator of melanoma invasion
7. New high-throughput screening technique makes probing puzzling proteins possible
8. Scripps research scientists watch as individual alpha-synuclein proteins change shape
9. Inactivity of proteins behind longer shelf life when freezing
10. Caltech and UCSD researchers shed light on how proteins find their shapes
11. Inhibiting proteins may prevent cartilage breakdown in arthritis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... Researching the safety of nanoparticles is all the rage. ... topic, examining the question of whether titanium dioxide nanoparticles ... into the body, whether carbon nanotubes from electronic products ... to be or whether nanoparticles in food can get ... Public interest is great, research funds are flowing – ...
(Date:10/29/2014)... LANSING, Mich. – As bodies decompose, their types ... the clues they provide could mean the difference ... , Michigan State University is using a more ... help Detroit death-scene investigators examine these changing populations. ... as geographical location of death, gender, race, socioeconomic ...
(Date:10/29/2014)... One kind of stem cell, those referred to as ... There is apparently nothing that differentiates these cells from ... namely they retain the capacity to become stem cells ... liver, an organ that hosts cells that stimulate tissue ... the case of a transplant. Knowledge of the ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3MSU partners with Detroit to investigate death scenes 2A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2
... , , WALL, N.J., Dec. ... BKYI), a leader in finger-based biometric identification solutions, ... world,s most respected security publications, named BIO-key International ... Access Control sub-category Biometrics. , (Logo: ...
... , , , , ... states are spending more on protecting their borders, which ... trafficking. High investment in advanced technology security and IT-based ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , New analysis from Frost & ...
... As soon as babies are born, they are susceptible ... For up to a month, their immune systems aren,t ... often minor, they can lead to serious problems if ... of Missouri researchers have pinpointed a group of depleted ...
Cached Biology News:BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 3Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 2Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 3Researchers work on vaccine to improve immune system in newborns 2
(Date:10/30/2014)... October 30, 2014 Spartan Bioscience announced ... RX CYP2C19 System . It detects CYP2C19 genetic mutations ... swab. , The Spartan RX CYP2C19 System is the ... been approved in Canada. Due to the system’s ease ... be used by healthcare professionals such as doctors, nurses, ...
(Date:10/30/2014)... October 30, 2014 Avure Technologies celebrates a ... the newest member of its fleet of high volume High ... an anniversary as we return to PackExpo this year, which ... in Las Vegas,” said Jeff Williams, CEO at Avure. “Sales ... we’re pleased to be meeting the challenges of market demand ...
(Date:10/30/2014)... CARLSBAD, Calif. , Oct. 30, 2014 Isis ... antisense therapeutics, today announced that management will present a company ... 2014 at 8:30 a.m. ET in Boston, MA. ... will be available on the "Investors & Media" section of ... available on the Isis website within 48 hours and will ...
(Date:10/30/2014)... RIDGE, N.J. , Oct. 30, 2014  Regado ... that it will hold a conference call and live ... a.m. EST to discuss its third quarter 2014 financial ... the conference call by dialing (888) 347-1165 for domestic ... call will be webcast live under the investor relations ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2
... Raptor,Pharmaceuticals Corp. ("Raptor" or the "Company") (OTC ... development division, Bennu,Pharmaceuticals Inc. ("Bennu"), has acquired ... the exclusive worldwide license to EC,Cysteamine, developed ... San Diego, School of Medicine, by way ...
... Dec. 17 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: ... molecular diagnostic,tests for the early detection of ... it has started collecting patient samples,for clinical ... development,ColonSentry(TM)., In June 2006, GeneNews presented ...
... is a new drug being,studied to prevent fractures in ... 3 clinical trial using denosumab were presented,Friday evening at ... from the Seattle Cancer Care Alliance., Denosumab is ... -- specialized cells that break down bone. Because it ...
Cached Biology Technology:Raptor Pharmaceuticals Acquires Orphan Clinical Program 2Raptor Pharmaceuticals Acquires Orphan Clinical Program 3Raptor Pharmaceuticals Acquires Orphan Clinical Program 4Raptor Pharmaceuticals Acquires Orphan Clinical Program 5Raptor Pharmaceuticals Acquires Orphan Clinical Program 6GeneNews initiates patient sample accrual for validation studies of colon cancer blood test 2GeneNews initiates patient sample accrual for validation studies of colon cancer blood test 3New Drug to Prevent Bone Loss Caused by Breast Cancer Treatment 2
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
... cells (HSC) are well-characterized tissue-specific stem cells ... responsible for the life-long maintenance of the ... reside in adult bone marrow where hematopoiesis ... be found in cord blood, fetal liver, ...
Biology Products: