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Biomimetic patch to be tested on tricky tendon-to-bone repairs
Date:2/28/2011

ll can be confirmed by looking for markers of each type of mature cell.

Tiny shoulders

"The newly manufactured scaffold looks like a sheet of paper and can be cut to fit the tendon tear," says Xia.

The team has taken the method as far as they can in vitro and are now ready to try it in a small animal model, the rat.

Galatz, who will perform the surgeries, will create a tear in the rat's rotator cuff, repair it with a suture, and then lay a piece of the biomimetic scaffold (a few millimeters wide and long) over the repair site.

"You wouldn't think it," says Thomopoulos, "but a rat's shoulder is surprisingly similar to ours. A study done years ago compared the shoulder anatomy of 34 different species, and aside from the primates, the rat bony and muscular anatomy was actually closest to ours."

"Rats are quadrupeds, but if you observe rats in their cages, they're reaching overhead quite a bit," he says


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Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

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