Navigation Links
Biomimetic patch to be tested on tricky tendon-to-bone repairs
Date:2/28/2011

r a new one had formed.

The biomimetic fix

Because the grading between tendon and bone occurs at both microscopic and nanoscopic levels, Thomopoulos teamed up with Xia, an expert in nanotechnology, to find a solution to this problem.

In 2009, Xia and Thomopoulos proposed a simple solution: a temporary scaffold that will guide the healing process along the path it follows during development.

"A few scaffolds have been attempted in rotator cuff repair in humans," says Thomopoulos, "with only limited success. These patches are fairly compliant materials, even compared to tendon. The hope is that they'll stimulate a better healing response, but it hasn't happened yet. Our scaffold approach is to mimic the natural tissue by stepping up gradually in stiffness from tendon to bone."

The WUSTL scaffold consists of a mat of nanoscopic fibers electrospun in Xia's lab that mimics the structure of the collagen fibers in a tendon. The mat is then coated with a continuous gradient of hydroxyapatite, a mineral containing calcium and phosphorus that gives strength to bone, so that it is stiff and bone-like toward one end and compliant and tendon-like toward the other.

Finally the scaffold is seeded with adult mesenchymal stem cells, a type of stem cell that can mature into osteoblasts (bone-forming cells) or fibroblasts (cells common in tendon).

The idea is that as the fibers disintegrate over the course of a few months, the mineral gradient will promote the graduated differentiation of the stem cells. Stem cells toward the bone end will be coaxed by the presence of mineral to differentiate into osteoclasts while the stem cells at the tendon end, surrounded by aligned, unmineralized fibers, will form fibroblasts.

"The tendon side is a little bit easier because stem cells tend to go toward the fibroblast-like lineage if you don't do much to them," says Thomopoulos.

The presence of either type of ce
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NSF funds innovative approach to biomimetic nanofiber bone regeneration
2. Fly eye paves the way for manufacturing biomimetic surfaces
3. Oceanic garbage patch not nearly as big as portrayed in media
4. NIH awards $10 million to advance microneedle patch for flu vaccination
5. Stem cell patch may result in improved function following heart attack
6. New pump created for microneedle drug-delivery patch
7. Ocean stirring and plankton patchiness
8. Even small patches of urban woods are valuable for migrating birds
9. Ancient artifacts reveals as northern ice patches melt
10. Penn team uses self-assembly to make molecule-sized particles with patches of charge
11. Isolated forest patches lose species, diversity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biomimetic patch to be tested on tricky tendon-to-bone repairs
(Date:10/29/2014)... is open for the Society of Interventional ... 2015 is the one place where interventional ... health care professionals can come together to ... technologies being presented, discussed and tested. ... invasive, image-guided medicine, SIR 2015 will feature ...
(Date:10/29/2014)... a ceremony held in New York City on September ... the American Cancer Society Professor of Genome Sciences and ... 2008 Honorary Doctor of Philosophy of Tel Aviv University, ... Medical Science. , In addition to her honorary degree ... at the TAU School of Medicine, and for the ...
(Date:10/29/2014)... 27, 2014 — Cambridge, MA and Hebei, China — ... complete, high quality sequencing of the Jujube genome. Jujube ... family, and the Jujube genome is particularly difficult to ... complicating factors. It is the first time that a ... This study has been recently published in ...
Breaking Biology News(10 mins):SIR 2015: Interventional radiology shapes tomorrow's medicine 2Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2
... Aquaculture production of seafood will probably remain the ... according to an assessment published in the January 2009 ... S. Diana of the University of Michigan at Ann ... harmful effects of aquaculture, the technique may, when practiced ...
... Yan Liu imagine and assemble intricate structures on a ... DNA molecule, a versatile building material offering near limitless ... issue of Science , Yan and Liu, researchers ... of Chemistry and Biochemistry, reveal for the first time ...
... Hopkins neuroscientists has worked out how some newly discovered ... with the brain. The report appears online this week ... are a small number of nerve cells in the ... in the retinarods and conesmelanopsin-containing cells are not used ...
Cached Biology News:Aquaculture's growth seen as continuing 2The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes 2The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes 3Bright lights, not-so-big pupils 2Bright lights, not-so-big pupils 3
(Date:10/30/2014)... 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... management will present a company overview at the Nomura Biotechnology ... in Boston, MA. A ... "Investors & Media" section of the Company,s website, www.isispharm.com ... within 48 hours and will be archived for a limited ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at ... with Bryan Hamilton, the publisher of the Triangle Business Journal, ... the Research Triangle region of North Carolina. , Just a ... roundtable include the role of social media in recruitment, ... and the unique role that Millennials play in the workplace ...
(Date:10/27/2014)... The “Molecular Diagnostic Market by Application (Infectious ... Sequencing), End User (Hospital, Laboratories), & by Product ... 2018” provides a detailed overview of the major ... strategies impacting the global molecular diagnostics market along ... and share analysis. , The global molecular diagnostics ...
(Date:10/27/2014)... HORSHAM, Pa. , Oct. 27, 2014 /PRNewswire/ ... Colitis Foundation of America (CCFA) announced today the ... , an educational campaign designed ... bowel diseases (IBD) on the paired role of ... To view the multimedia assets associated with ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4
... Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion ... , , Shiaw-Lin Wu, Pavel Bondarenko, Tom Shaler, , ... , , , Protein Glycosylation , ... acquired using , any Thermo Finnigan LCQTMion trap mass spectrometer with MS n ...
... , , , Andreas Hhmer, Helen Tran, and William , ... , , Protein Oxidation , ... trap mass spectrometer with MS n capability. , ... Calmodulin (CaM) is the primary high-affinity Ca 2+ -binding protein , ...
... , , , , , ... cultures , requires double-stranded molecules known as short interfering ... siRNA, offering a custom , siRNA oligonucleotide synthesis ... common target genes, and a Cancer , siRNA ...
Cached Biology Technology:Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion Trap MSn 2Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion Trap MSn 3Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion Trap MSn 4Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion Trap MSn 5Structural Analysis of Glycosylated Peptides in Complex Mixtures with , Ion Trap MSn 6Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray , Ion Trap Mass Spectrometry 2Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray , Ion Trap Mass Spectrometry 3Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray , Ion Trap Mass Spectrometry 4Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray , Ion Trap Mass Spectrometry 5Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray , Ion Trap Mass Spectrometry 6RNAi Gene Silencing System 2RNAi Gene Silencing System 3
... ,Schistosomal glutathione-S-transferase (GST) is commonly used as ... E. coli (1). The GSTTag sequence has ... in some cases the solubility of its ... properly folded form, GSTTag fusion proteins can ...
... The Bio-Stack is compatible with BioTeks ... Speed, ease of use and walkaway ... microplate process. When used with the ... dispenser, the Bio-Stacks small footprint fits ...
... for the use of small interfering RNA ... the RNA interference,(RNAi) pathway have generated tremendous ... fields. siRNA for experimental use can be,synthesized ... then transfected into the target cells in ...
... Array Service enables scientists who have access to ... FAST Slides printed with proteins from S&Ss antibody ... the arrays is performed by the customer. Its ... discuss your needs with an expert and define ...
Biology Products: