Navigation Links
Biomedical researchers create artificial human bone marrow in a test tube
Date:12/22/2008

ld on which the artificial marrow grows. This lattice had to have a high number of precisely-sized pores to stimulate cellular interaction.

The scaffolds are made out of a transparent polymer that nutrients can easily pass through. To create the scaffolds, scientists molded the polymer with tiny spheres ordered like billiard balls. Then, they dissolved the spheres to leave the perfect geometry of pores in the scaffold.

The scaffolds were then seeded with bone marrow stromal cells and osteoblasts, another type of bone marrow cell.

"The geometrical perfection of the polymer molded by spheres is very essential for reproducibility of the drug tests and evaluation of potential drug candidates," Kotov said. "The scaffold for this work had to be designed from scratch closely mimicking real bone marrow because there are no suitable commercially products.

"Certain stem cells that are essential for immunity and blood production are able to grow, divide and differentiate efficiently in these scaffolds due to the close similarity of the pores in the scaffold and the pores in actual bone marrow."

The researchers demonstrated that the artificial marrow gives a human-like response to an infectious New Caledonia/99/H1N1 flu virus. This is believed to be a first.

To determine whether the substance behaves like real bone marrow, the scientists implanted it in mice with immune deficiencies. The mice produced human immune cells and blood vessels grew through the substance.


'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-1838
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Miami biomedical engineer
2. Biomedical research profits from the exploration of the deep sea
3. Biomedical engineers detective work reveals antibiotic mechanism
4. Supercomputer provides massive computational boost to biomedical research at TGen
5. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
6. NJIT biomedical engineer receives NSF Career Development Award
7. Springer expands publishing partnership with the Biomedical Engineering Society
8. UVa biomedical engineering study shows magnetic field can reduce swelling
9. Phase 2 of Singapores Biomedical Sciences Initiative gains momentum for clinical research
10. USC biomedical team to participate in $6 million low vision project
11. $22 million gift from Alfred Taubman launches new biomedical research institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014  Spectra Automation, a trusted supplier ... and power generation industries, announced today the ... an easy-to-use and cost-effective data collection, analysis ... laboratories. Most upstream process ... systems. Accessing and consolidating data from these ...
(Date:9/29/2014)... Clostridium ramosum , coupled with a high-fat diet, may ... week in mBio , the online open-access journal of ... from the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal ... ramosum gained weight when fed a high-fat diet. Mice ... obese even when consuming a high-fat diet, and mice that ...
(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Gut bacteria promote obesity in mice 2
... food meal is never good for you, but washing that ... a new University of Guelph study. Researcher Marie-Soleil Beaudoin ... levels spike after eating a high-fat meal, but that the ... coffee jumping to levels similar to those of people ...
... leaves influence the sunlight reaching inner canopy leaves by changing ... physiology of leaves within the tree canopy is not constant, ... crown. This phenomenon is expected to have important consequences for ... A new study describes how the leaves in the outer ...
... ARBOR, Mich.Getting older doesn,t mean giving up muscle strength. ... loss that comes with age, but the Golden Years can be ... Michigan Health System. "Resistance exercise is a great ... people can function more readily in daily life," says Mark Peterson, ...
Cached Biology News:Got a craving for fast food? Skip the coffee, study says 2Older and stronger: Progressive resistance training can build muscle, increase strength as we age 2Older and stronger: Progressive resistance training can build muscle, increase strength as we age 3Older and stronger: Progressive resistance training can build muscle, increase strength as we age 4
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... 2014 Report Details Biosimilar drugs ... revenues Do you want to find sales potentials ... predictions for those biological drugs from 2014, helping ... financial data, R&D trends, opportunities and selling prospects. ... to 2024 at overall world market, therapeutic class, ...
(Date:9/30/2014)... September 30, 2014 Over the last ... due to rising R&D budgets and increased acceptance of ... growing pharmaceutical and biotechnology industries are also catalyzing the ... filtration market is expected to grow at a strong ... estimated to be worth $2,532.6 million by 2019. The ...
(Date:9/30/2014)... , Sept. 30, 2014  RegeneRx Biopharmaceuticals, ... announced that it has received a Canadian Patent ... Actin-Sequestering Peptides.  This patent includes claims using thymosin ... other actin-sequestering peptides for these purposes.  The patent ... RegeneRx Biopharmaceuticals, Inc. ( www.regenerx.com ) ...
Breaking Biology Technology:A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2
... Tetrahedral dice, which have four triangular sides, pack ... to research performed by a collaboration of New York ... result of a series of experiments that involved pouring ... dice until the containers were completely filled. After adding ...
... 3 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. ( ANPI, TSX: ANP), a specialty ... exclusive distribution agreement with B. Braun for its proprietary Quill(TM) SRS product line ... The term of the distribution agreement will be for five years. , ... According to The Royal College of Surgeons ...
... , LAWRENCEVILLE, N.J. , May 3 ... (n = 520) multi-center patient registry study of its Lacrisert® ... index (OSDI) in patients with moderate-to-severe dry eye after one ... poster this week during the 2010 Annual Meeting of the ...
Cached Biology Technology:Densest dice packing and computing with molecules 2Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 2Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 3Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 4Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 5Study of Lacrisert(R) Dry Eye Insert 2Study of Lacrisert(R) Dry Eye Insert 3Study of Lacrisert(R) Dry Eye Insert 4Study of Lacrisert(R) Dry Eye Insert 5
... thermocycler provides maximum performance on minimum space. ... elements, high heating and cooling rates have ... times. With a maximum capacity of 48 ... the capacity of much more expensive 96 ...
Sf21 Insect Cells (Live) in Max-XP Medium...
Dual-bay Dyad thermal cycler chassis, does not include the Alpha units (requires 2)...
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Biology Products: