Navigation Links
Biomedical engineers' detective work reveals antibiotic mechanism
Date:11/17/2008

(Boston) -- A series of genetic clues led a team of Boston University biomedical engineers to uncover exactly how certain antibiotics kill bacteria. The findings could help rejuvenate the efficacy of older antibiotics and reveal new antibiotic targets within bacterial cells.

"The research speaks to new insights into how current antibiotics work and how those insights can point toward development of more effective antibiotics," said James Collins, Professor of Biomedical Engineering at Boston University.

He is the senior author of a paper in the November 14th issue of Cell which describes the details of this pathway, particularly the initial trigger of this deadly sequence of events.

Collins and his colleagues used systems biology approaches to identify clusters of genes that became more active in the bacteria treated with antibiotics. The researchers then reconstructed the series of events leading to antibiotic-mediated bacterial death, using the changes in these genes as clues.

"Modern tools allow the simultaneous analysis of the many interacting components that make up complex biological systems,'' said Jeremy M. Berg, director of the National Institutes of General Medical Sciences at the National Institutes of Health. "Using such a systems approach, Dr. Collins and his coworkers revealed a surprising mechanism of action for certain antibiotics. This lays the foundation for further antibiotic development -- a pressing drug development need." said Jeremy M. Berg, director of the National Institutes of General Medical Sciences.

Previously, Collins, Boston University doctoral candidate Michael Kohanski, and colleagues found a common mechanism of cell death in bacteria. They reported that several different classes of antibiotics all had this same underlying pathway that caused over-production of hydroxyl radical molecules which contributed to bacterial cell death.

The group's new research focu
'/>"/>

Contact: Ronald Rosenberg
ronrosen@bu.edu
617-358-1240
Boston University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Supercomputer provides massive computational boost to biomedical research at TGen
2. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
3. NJIT biomedical engineer receives NSF Career Development Award
4. Springer expands publishing partnership with the Biomedical Engineering Society
5. UVa biomedical engineering study shows magnetic field can reduce swelling
6. Phase 2 of Singapores Biomedical Sciences Initiative gains momentum for clinical research
7. USC biomedical team to participate in $6 million low vision project
8. $22 million gift from Alfred Taubman launches new biomedical research institute
9. Boston University biomedical engineers find chink in bacterias armor
10. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
11. UC San Diego bioengineers fill holes in science of cellular self-organization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces the second shipment ... underway to early access pre-order customers. ... retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop ... accepted at all outlets and very easy to use. ...
(Date:3/30/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has ... Market in Automotive Sector 2014-2018" report to their ... Recognition market in Automotive Sector to grow at a ... Gesture recognition is the ability of a device to ... Gesture recognition technology can be 2D-based or 3D-based. It ...
(Date:3/24/2015)... --  NexID Biometrics LLC, whose spoof-mitigation technology boosts ... the beginning of shipments of version 2.0 of its ... based in Potsdam, N.Y. , is ... began here today at the Walter E. Washington Convention ... SDK boosts the accuracy rate range to 96.5 to ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... TORONTO A study led by scientists at The ... identifying drugs to treat children suffering from fatal cancers for ... developing a new drug from scratch, which is a complicated ... lab, they tested existing drugs on cancer stem cells from ...
... at Montana State University have developed six new biomedical ... infections, fungal infections and viral infections; boosting humans, innate ... The technologies are available for licensing to ... involves an existing clinical drug that was discovered to ...
... Market - Advanced Technologies, Global Forecast and Winning Imperatives... -- DALLAS, August 18, 2010 ... ... --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab ...
Cached Biology News:Scientists find new twist on drug screening to treat common childhood cancer 2Scientists find new twist on drug screening to treat common childhood cancer 3Montana State University offers 6 new biomedical technologies for licensing 2Montana State University offers 6 new biomedical technologies for licensing 3Montana State University offers 6 new biomedical technologies for licensing 4New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 2New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 3New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 4New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 5New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 6New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 7
(Date:4/30/2015)... MN , April 30, 2015 /PRNewswire/ - BioAmber ... producing sustainable chemicals, today announced that it has commenced an ... BioAmber expects to grant the underwriters a 30-day option ... the shares of common stock offered in the public ... there can be no assurance as to whether or ...
(Date:4/30/2015)... The following is an open letter sent April ... Blood Corp (NYSE: CO ) from Jayhawk Capital. ... directors of China Cord Blood Corp (" China Cord ") ... share from Golden Meditech Holdings Co Ltd ("Golden Med"). Certainly, ... benefit Golden Med and Mr. Kam, the Chairman of both ...
(Date:4/30/2015)... , April 30, 2015  Pfenex Inc. (NYSE ... the development of biosimilar therapeutics including high value ... closing of its previously announced underwritten public offering ... a public offering price of $15.50 per share. ... underwriters of their option to purchase up to ...
(Date:4/30/2015)... 30, 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" ... global contract R&D services provider, today announced that its ... letter, dated April 29, 2015, from a consortium (the ... "Chairman"), founder, chairman and chief executive officer of the ... proposes a transaction (the "Transaction") involving the acquisition of ...
Breaking Biology Technology:BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6
... May 13 Xennex, Inc. (Xennex) announced today ... of Version 3.0 beta, available at ... 3.0 features a significantly upgraded infrastructure, including a ... and speedier search engine. It provides capabilities for ...
... OF INDUSTRY, Calif. and HONG KONG, May 13 ... that its 49% owned subsidiary, Excalibur International Marine Corporation, ... Taiwan Strait between Taiwan and Mainland China. Excalibur,s ... and is capable of carrying over 300 tons of ...
... DIEGO, May 12 Amylin Pharmaceuticals, Inc. (Nasdaq: ... Care Conference on Tuesday, May 19, 2009 at ... Daniel M. Bradbury, president and chief executive officer of Amylin ... session will be webcast, and a recording will be made ...
Cached Biology Technology:GeneCards(R) Version 3.0 Beta Released 2GeneCards(R) Version 3.0 Beta Released 3EFT BioTech Holdings, Inc.'s Subsidiary Receives First Permit to Cross Taiwan Strait 2EFT BioTech Holdings, Inc.'s Subsidiary Receives First Permit to Cross Taiwan Strait 3
... for interferons are cytopathic effect inhibition assays, also ... types include; tissue culture supernatents; serum from PK ... one unit is defined as the quantity of ... effect of viral infection by 50%. ...
... cytopathic effect inhibition assays, also known as CPE ... culture supernatents; serum from PK studies and delivery ... defined as the quantity of interferon required per ... infection by 50%. All standards used ...
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
Request Info...
Biology Products: