Navigation Links
Biomedical breakthrough: Blood vessels for lab-grown tissues
Date:1/11/2011

Researchers from Rice University and Baylor College of Medicine (BCM) have broken one of the major roadblocks on the path to growing transplantable tissue in the lab: They've found a way to grow the blood vessels and capillaries needed to keep tissues alive.

The new research is available online and due to appear in the January issue of the journal Acta Biomaterialia.

"The inability to grow blood-vessel networks -- or vasculature -- in lab-grown tissues is the leading problem in regenerative medicine today," said lead co-author Jennifer West, department chair and the Isabel C. Cameron Professor of Bioengineering at Rice. "If you don't have blood supply, you cannot make a tissue structure that is thicker than a couple hundred microns."

As its base material, a team of researchers led by West and BCM molecular physiologist Mary Dickinson chose polyethylene glycol (PEG), a nontoxic plastic that's widely used in medical devices and food. Building on 10 years of research in West's lab, the scientists modified the PEG to mimic the body's extracellular matrix -- the network of proteins and polysaccharides that make up a substantial portion of most tissues.

West, Dickinson, Rice graduate student Jennifer Saik, Rice undergraduate Emily Watkins and Rice-BCM graduate student Daniel Gould combined the modified PEG with two kinds of cells -- both of which are needed for blood-vessel formation. Using light that locks the PEG polymer strands into a solid gel, they created soft hydrogels that contained living cells and growth factors. After that, they filmed the hydrogels for 72 hours. By tagging each type of cell with a different colored fluorescent marker, the team was able to watch as the cells gradually formed capillaries throughout the soft, plastic gel.

To test these new vascular networks, the team implanted the hydrogels into the corneas of mice, where no natural vasculature exists. After injecting a dye into the mice's bloodstream, the researchers confirmed normal blood flow in the newly grown capillaries.

Another key advance, published by West and graduate student Joseph Hoffmann in November, involved the creation of a new technique called "two-photon lithography," an ultrasensitive way of using light to create intricate three-dimensional patterns within the soft PEG hydrogels. West said the patterning technique allows the engineers to exert a fine level of control over where cells move and grow. In follow-up experiments, also in collaboration with the Dickinson lab at BCM, West and her team plan to use the technique to grow blood vessels in predetermined patterns.


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Related biology news :

1. Statistician wins $150K scholarship to interpret biomedical data
2. UVic biomedical engineer outsmarts HIV
3. UTHealth School of Biomedical Informatics professor to be inducted to AIMBE College of Fellows
4. Biomedical and health professionals converge in D.C. to absorb new findings in science of informatics
5. Fish gelatin: Ultra-high-tech biomedical uses ahead?
6. Plagiarism sleuths tackle full-text biomedical articles
7. UMMS biomedical researchers develop more reliable, less expensive synthetic graft material
8. Knome Awards Human Exome Sequencing and Analysis to Biomedical Researchers
9. LSU receives $15 million grant from NIH to build biomedical research pipeline for Louisiana
10. MARC Travel Awards announced for the 2010 Biomedical Engineering Society Annual Meeting
11. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/8/2016)... ANGELES and MANCHESTER, United Kingdom ... ("BBI"), a developer of innovative sensor-based diagnostic products, today announced ... financed by new and existing investors.  Proceeds from the financing ... SEM Scanner , a hand-held device for detecting early-stage pressure ... Ireland after receiving CE Mark approval. ...
(Date:1/7/2016)... YORK , Jan. 7, 2016 This ... regional markets for biometric technologies and devices, identifying newer ... market for various types of biometric devices. Includes forecast ... to: Identify newer markets and explore the expansion ... biometric devices. Examine each type of biometric technology, determine ...
(Date:1/7/2016)... -- A United States District Court in Illinois ... to interpret a biometric privacy statute in a decision ... photo website Shutterfly brought by the law firm Carey Rodriguez ... SHUTTERFLY, INC.; and THISLIFE, INC ( N.D. Ill ., ... Illinois Biometric Privacy Act by collecting and scanning face ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , ... February 08, 2016 , ... Information Management Services ... product. The upgrade represents a completely new technical foundation and is so significant ... a responsive design interface, significantly increased speed for search results, a streamlined layout and ...
(Date:2/8/2016)... (NYSE MKT: NNVC) (the "Company"), a nanomedicine company developing anti-viral drugs, ... present information about the company,s programs at the BIOCEO conference today ... City . --> --> ... Registered attendees can request a one on one meeting through the conference ... --> New York City . --> ...
(Date:2/8/2016)... -- --> --> ... ultra-rapid Point-Of-Care (POC) molecular diagnostics company, today announces that it ... test to be launched on the Company,s io® platform. By ... test is now cleared for sale within the European Union. ... of the io® CT test signals a new era in ...
(Date:2/5/2016)... -- ATCC, the premier global biological materials resource and ... life science researchers that are working to address the ... CDC website . --> CDC website ... single-stranded RNA virus of the Flaviviridae family, genus Flavivirus, ... Viruses. Zika virus is transmitted to humans primarily through ...
Breaking Biology Technology: