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Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
Date:4/30/2008

to find cancer in the subsequent biopsy is 90 percent, Paciucci said. Currently, the diagnosis of cancer is made only when the cancer lesion is seen in the biopsy.

By adding the analysis of PTOV1, the positive predictive value (the chance that the HG-PIN lesion will become cancerous) of all samples, including those with a score of less than 100, is 34 percent, and the negative predictive value (the chance that the HG-PIN lesion will not become cancerous) is more than 95 percent, Paciucci says.

Paciucci cautions that the study results need to be confirmed among a larger study group. From this validation we can expect to improve the current rate of early detection of cancer, she said.


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Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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