Navigation Links
Biomagnetics developed for use in new breast cancer tests

A team from UCL has developed a new medical device which will make the early detection of breast cancer more cost effective and easier to administer. The team - which won a prestigious Brian Mercer Feasibility Award from the Royal Society yesterday - plans to use magnetic nanoparticles and an extremely sensitive magnetometer called the HistoMag to detect cancerous cells in samples of breast tissue.

Each year 35,000 women are diagnosed with breast cancer in the UK and the testing programme is a massive undertaking, says Professor Quentin Pankhurst of the London Centre for Nanotechnology and the UCL Department of Physics & Astronomy. Until now, pathologists had to stain tissue samples with brown dyes to help them determine whether they were normal or cancerous. In terms of streamlining the process, the main problem is that all of the results are open to interpretation and each test has to be individually checked by a specialist.

At UCL weve been working in the relatively new area of biomagnetics to develop a technique which provides more quantitative and reliable results, whilst also enabling pathologists to identify abnormal tissue sections much more quickly.

Cancerous cells have a protein on their surface called HER2. We use a solution of HER2 antibodies, tagged with magnetic nanoparticles, to stain the tissue sample. Using the HistoMag we can detect the quantity of tagged antibodies which attach themselves to the HER2 protein, which in turn provides us with an accurate picture of the spread of cancerous cells.

By automating the process through which cancerous cells are detected and quantified, HistoMag will not only ease the pressure on pathologists but also help to identify the 15-30% of patients who are likely to benefit from being treated with the drug Herceptin. At a cost of 30,000 per patient per annum it is essential to target Herceptin at those women who will respond positively to it.

The team, led by Professor Pankhurst, is one of only seven groups to receive a Brian Mercer Feasibility Award from the Royal Society this year. The 25,000 award will enable the team to re-engineer the HistoMag, increasing its sensitivity before it goes on to clinical trials. Their goal is to make the device generally available to pathologists in 2010.


Contact: Dave Weston
University College London

Related biology news :

1. A new radiation therapy treatment developed for head and neck cancer patients
2. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
3. New southernpeas developed by ARS, cooperators
4. New method developed to identify genetic determinants of Alzheimers disease
5. Newly created cancer stem cells could aid breast cancer research
6. Linchpin gene may be useful target for new breast cancer therapies
7. Dietary calcium could possibly prevent the spread of breast cancer to bone
8. Researchers find new gene linked to breast cancer
9. Analysis of breast and colon cancer genes finds many areas of differences between tumors
10. Genome update defines landscape of breast and colon cancers
11. AACR, BCRF award inaugural grants in translational breast cancer research
Post Your Comments:
Related Image:
Biomagnetics developed for use in new breast cancer tests
(Date:11/17/2015)... , November 17, 2015 ... au 19 novembre  2015.  --> Paris ... --> DERMALOG, le leader de l,innovation biométrique, ... la fois passeports et empreintes sur la même surface ... les passeports et l,autre pour les empreintes digitales. Désormais, ...
(Date:11/12/2015)... BOSTON , Nov. 12, 2015  A golden ... for Duchenne muscular dystrophy (DMD) has provided a new ... Boston Children,s Hospital, the Broad Institute of MIT and ... Brazil . Cell, ... some dogs "escape" the disease,s effects. The Boston Children,s ...
(Date:11/10/2015)...  In this report, the biomarkers market ... type, application, disease indication, and geography. The ... consumables, services, software. The type segments included ... biomarkers, and validation biomarkers. The applications segments ... drug discovery and development, personalized medicine, disease ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: HALO ... New York on Wednesday, December 2 at ... , president and CEO, will provide a corporate overview. ... at 1:00 p.m. ET/10:00 a.m. PT . ... will provide a corporate overview. --> th Annual ...
(Date:11/24/2015)... 24, 2015  Clintrax Global, Inc., a worldwide provider of clinical ... today announced that the company has set a new quarterly earnings ... on quarter growth posted for Q3 of 2014 to Q3 of ... Mexico , with the establishment of an ... --> United Kingdom and Mexico ...
(Date:11/24/2015)... , November 24, 2015 ... recent market research report released by Transparency Market Research, ... expand at a CAGR of 17.5% during the period ... Testing Market - Global Industry Analysis, Size, Volume, Share, ... global non-invasive prenatal testing market to reach a valuation ...
(Date:11/24/2015)... ... 2015 , ... InSphero AG, the leading supplier of easy-to-use solutions for production, ... to serve as Chief Operating Officer. , Having joined InSphero in November ... and was promoted to Head of InSphero Diagnostics in 2014. There she has ...
Breaking Biology Technology: