Navigation Links
Biology of infection: A bacterial ballistic system
Date:6/20/2014

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a crucial part of one of these systems which are possible targets for novel antibiotics.

Bacteria secrete a broad range of specific proteins that can affect the behavior or survival of cells in their environment. Among the specialized transport systems responsible for the export of such factors are so-called Type VI secretion systems. In collaboration with Axel Mogk of the Center for Molecular Biology Heidelberg (ZMBH), biochemist Petra Wendler at the LMU's Gene Center has now determined the three-dimensional structure of one of these export complexes. "Bacterial species employ these systems primarily to secrete specific toxic proteins directed against competitors or host cells. The protein complexes involved in secretion essentially function as nanosyringes," says Wendler.

Type VI secretion systems were discovered only a few years ago, but they are synthesized by many bacterial species, including important pathogens, such as Vibrio cholerae, the bacterium that causes cholera, and Pseudomonas aeruginosa which can induce severe lung damage during chronic infections. While antibiotic resistance continues to rise, there is a pressing need for alternative ways to combat bacterial pathogens. In this context, Type VI secretion systems offer an interesting target, as blocking their function would effectively disarm pathogenic bacteria in a highly specific manner.

The contractile sheath

"However, in order to identify weak points in this bacterial secretion system, we need to obtain further insights into how its export machinery works," says Wendler. "A tubular protein complex was recently characterized, which contracts to expel toxins from the cell. Besides characterizing a possible target for novel antibiotics, we were part
'/>"/>

Contact: Luise Dirscherl
presse@lmu.de
0049-892-180-3423
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Planarian genes that control stem cell biology identified
2. New synthetic biology technique boosts microbial production of diesel fuel
3. Carnegies Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology
4. Biology professor secures grant to save West Virginias primary natural history collection
5. The American Society for Microbiology honors Ellen Jo Baron
6. SF State biology department receives $1.5 million to support science teaching
7. The American Society for Microbiology honors Bess B. Ward
8. The American Society for Microbiology honors I. Kaye Wachsmuth
9. The American Society for Microbiology honors Geoffrey L. Smith
10. The American Society for Microbiology honors Susan Sharp
11. The American Society for Microbiology honors Anthony R. Richardson
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... mechanical force that a single fungal cell or bacterial colony ... it plays a heavy role in setting up some of ... may not be too much of a stretch to say ... ability to respond to the touch of beneficial fungi, according ... of agronomy at the University of Wisconsin-Madison. , "Many ...
(Date:8/27/2014)... Calif. , Aug. 27, 2014  WaferGen Bio-systems, ... its previously announced underwritten public offering of units of ... per unit for gross proceeds of $20 million, prior ... payable by the Company.  The shares and warrants are ... Each unit sold in the offering consists of ...
(Date:8/27/2014)... mastodons, short-faced bears, giant ground sloths, saber-toothed cats and ... years ago at the end of the Pleistocene period. ... debated by scientists who, until recently, could only speculate ... UC Santa Barbara,s James Kennett, professor emeritus in the ... with Earth played a major role in the extinction. ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Nanodiamonds are forever 2Nanodiamonds are forever 3
... 12th International Coral Reef Symosium will bring together ... their science and hear their latest advances from ... research and findings are fundamental in informing international ... and sustainable use of coral reefs. WHAT: 12th ...
... are buzzing once again, and with that comes the threat ... Li Ka Shing Institute of Virology in the Faculty of ... end to this potentially serious infection. , West Nile ... and some in cases, infected people show no symptoms at ...
... The most common ailment to affect a horse is ... a way to detect this problem using a motion detection ... professor of equine surgery in the College of Veterinary Medicine ... lameness earlier than veterinarians using the traditional method of a ...
Cached Biology News:12th International Coral Reef Symposium 2Researchers moving towards ending threat of West Nile virus 2Motion sensors detect horse lameness earlier than veterinarians, MU study finds 2
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
(Date:8/27/2014)... Rhythm, a biopharmaceutical company developing peptide therapeutics that address ... disorders, announced today that it has filed a registration ... Exchange Commission (SEC) relating to the proposed initial public ... of shares to be offered and the price range ... Citigroup and Cowen and Company will act as ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... 27, 2014 Reportlinker.com announces that ... in its catalogue: Global Biodegradable ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About Biodegradable ... are readily decomposed by the action of ... packaging in terms of raw materials, production ...
Breaking Biology Technology:Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... on Wednesday, November 17, 2010 at 11:30 a.m. EST (8:30 ... Regis New York.  Steve Worland, Ph.D., President and Chief Executive ... its clinical development programs. The presentation will be ...
... Inc. announced today that the company has raised $7.1 ... The Series C round, which included 5 new investors, ... product VeriStrat®, a serum proteomic test that helps physicians ... (NSCLC). Existing shareholders of the company provided $5.1 million ...
... Business Unit Again Receives ,Best Places to Work in... -- SOUDERTON, Pennsylvania, November 10, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, ...
Cached Biology Technology:Anadys Pharmaceuticals to Present at the Lazard Healthcare Conference 2Biodesix Completes Series C Financing and Receives Grant 2Biodesix Completes Series C Financing and Receives Grant 3Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 2Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 3Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 4Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 5Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 6Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 7
... serum is collected from fasted mixed breed, mixed ... Available Anticoagulants: N-02: Citrate ... N-08: Potassium Oxalate N-10: ... ACD N-07: CPD N-09: ...
Ready-to-use; 40mg/ml X-Gal and 32mg/ml IPTG...
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Designed for flow cytometric applications intended to identify...
Biology Products: