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Biologists use flies and mice to get to the heart of Down syndrome
Date:11/4/2011

as observed among some of the more seriously affected DSCAM and COL6A2 over-producing mice," said Bier.

Bier added that the tiered genetic approach, using fruit flies, then mice, could be useful in identifying genes involved in other common genetic disorders that are thought to be caused by multiple genes.

"These conditions arise due to a surprising variation in the copy number of small intervals of human chromosomes that are carried by virtually all people," he said. "Depending on which small regions of the chromosome have extra or fewer copies of genes, various conditions can result including obesity, autism, and schizophrenia. Typically in these diseases, as in Down syndrome, the difficult puzzle is which of the possible genes with altered copy number are involved in causing the disease."


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Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

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