Navigation Links
Biologists use flies and mice to get to the heart of Down syndrome
Date:11/4/2011

stem with many of the same genes as mice and humans. With help from collaborators Amir Gamliel, Geoff Rosenfeld and Kirk Peterson at the UC San Diego School of Medicine, Rolf Bodmer and Karen Ocorr at the Sanford-Burnham Medical Research Institute, and Julie R. Korenberg at the University of Utah, biologist Tamar Grossman in Bier's lab devised a sequential genetic approach to untangle the problem.

"First, fruit flies were used to test for all possible pairwise genetic interactions between these genes that might disrupt the function of the simple fluid pumping fly heart," said Bier." These comprehensive genetic studies pointed to a particular pair of genes known as DSCAM and COL6A2 that resulted in the most severe defects when over-produced together."

Then the researchers tested the effects of increasing the levels of these genes in the hearts of experimental mice. They first generated genetic lines of mice having elevated activity of each of these genes in the heart and then genetically crossed these mice to create offspring that over-produced both genes together. The parental mice as well as their offspring were then tested for heart function and visible heart defects.

Mice having elevated levels of each gene separately were largely normal. But the offspring with extra levels of both genes suffered from severe cardiac defects. These heart defects were of two kinds. The first resembled one of the salient features of Down syndrome cardiac patients, in which blood shunts between the two atrial chambers of the heart through small holes in a septum that normally isolates these two chambers. The second defect, which is not frequently observed in Down syndrome patients, but is a common and very serious condition in the general population, was a thickening of the heart wallreferred to medically as cardiac hypertrophy.

"Such thickening of the heart wall greatly reduces heart function and can lead to fatal heart attacks, which indeed w
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Do bacteria age? Biologists discover the answer follows simple economics
2. American Society of Plant Biologists supports science outreach by grad students and postdocs
3. NYU biologists use Sinatra-named fly to show how to see the blues -- and the greens
4. FSU biologists fish for reasons behind endangered groupers comeback
5. Pitt biologists find surprising number of unknown viruses in sewage
6. UC San Diego biologists discover genes that repair nerves after injury
7. Biologists discovery may force revision of biology textbooks
8. Team led by IU biologists confirms sunflower domesticated in US, not Mexico
9. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
10. Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge
11. Cell biologists hail stem cell decision
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... June 30, 2015 To bolster its efforts and ... Corp. announced today the addition of two new team members. ... board advisor and David Raviv will act as ... HYPR Corp.,s commitment to providing the most secure solutions for ... co-founded Layer 7 Technologies, a provider of security and ...
(Date:6/25/2015)... , June 25, 2015  Imagine a tool ... toward a healthier, happier life. That,s exactly what USANA,s ... to do. The cutting-edge, portable health program provides a ... solutions to help improve your lifestyle and nutrition. ... dinner and gala Wednesday night, USANA,s THA was honored ...
(Date:6/24/2015)... Research and Markets( ... "Huawei Ascend Mate 7 Fingerprint Sensor - ... Huawei,s technological choice for the fingerprint ... Apple,s and Samsung,s one. The Ascend Mate 7 ... Cards, a main actor in capacitive sensing human ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... in China earlier this year has subsided for now, but ... apparent lull in infections. The virus has several highly unusual ... may yet lead to a pandemic, according to lead scientists ... Morens, Jeffery Taubenberger, and Anthony Fauci, in a paper published ...
... Utah , July 8, 2013 /PRNewswire-iReach/ -- Xyngular, a ... of top-quality supplements at affordable prices, has just announced the ... from extracts of pure natural herbal compounds as well as ... help increase physical energy and mental energy, as well as ...
... cold, poor harvests -- the year 1816 was a ... was the eruption of the Indonesian volcano Tambora a ... compounds into the stratosphere (at altitudes of 15-50 km) ... weakened solar radiation for several years afterwards. Such intense ...
Cached Biology News:H7N9 influenza: History of similar viruses gives cause for concern 2H7N9 influenza: History of similar viruses gives cause for concern 3Xyngular Announces the Launch of its New Xyng Enhanced Formula 2Xyngular Announces the Launch of its New Xyng Enhanced Formula 3Improved interpretation of volcanic traces in ice 2
(Date:7/1/2015)... and PARIS , ... AgBiome, and Genective, key developer of biotech crops, ... discovery of new generations of insect control traits. ... control to counter the realities of advancing insect ... aligning AgBiome,s unique insect control technology with Genective,s ...
(Date:7/1/2015)... HAMILTON, Bermuda , July 1, 2015 /PRNewswire/ ... biopharmaceutical company focused on the treatment of dementia, ... investor briefing on July 22 at 5:45 p.m. ... at the Alzheimer,s Association International Conference 2015 (AAIC). ... following remarks: , Dr. Lawrence ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... pathogen transmission. CTI’ new Medical Joysticks have an impermeable molecular barrier protection ... an operator control device that will increase healthcare worker safety and reduce financial ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... hosting a webinar to provide advanced scientific research into new classes of Nanoscale ... and energy. Touted as 'the wonder material of the 21st Century' by ...
Breaking Biology Technology:AgBiome and Genective collaborate to create novel insect-resistant crops 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4
... for patients with ADHD ages 6 to 65, ... common,emotional, cognitive and behavioral disorder treated in children(1), and,according ... 30,percent and 70 percent of children with ADHD continue ... to affect about eight million, or,one in 20, adults ...
... SAN FRANCISCO, June 27 VIA Pharmaceuticals,Inc. (Nasdaq: ... of,compounds for the treatment of cardiovascular disease, will join ... of,U.S. indexes on June 27 after market close, according ... , "We are pleased to have been selected ...
... 30 and 50 million people. In the infected patients, ... syndrome (ARDS). This fatal condition is a massive reaction ... damaged. ARDS can be induced by various bacterial and ... be toxic gases that are inhaled or gastric acid ...
Cached Biology Technology:FDA Approves CONCERTA(R) (methylphenidate HCI) Extended-release Tablets for Treatment of ADHD (Attention Deficit Hyperactivity Disorder) in Adults 2FDA Approves CONCERTA(R) (methylphenidate HCI) Extended-release Tablets for Treatment of ADHD (Attention Deficit Hyperactivity Disorder) in Adults 3FDA Approves CONCERTA(R) (methylphenidate HCI) Extended-release Tablets for Treatment of ADHD (Attention Deficit Hyperactivity Disorder) in Adults 4VIA Pharmaceuticals Set to Join Russell Microcap Index 2VIA Pharmaceuticals Set to Join Russell Microcap Index 3VIA Pharmaceuticals Set to Join Russell Microcap Index 4New strategies against bird flu 2
BDFastImmune? IFN-gamma /CD69/CD4/CD3 Storage Temperature: Refrigerate(2 to 8C)...
MAb to Transferrin Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Rabbit polyclonal to Phosphothreonine-X-Phosphotyrosine (HRP) ( Abpromise for all tested applications)....
Rabbit polyclonal to IRS1 (phospho S636) ( Abpromise for all tested applications). entrezGeneID: 3667 SwissProtID: P35568...
Biology Products: