"Hsp90 facilitates the assembly of guidance receivers during the production and also fixes flawed products whenever they are detected," says Andrew Chisholm, a professor of neurobiology and cell and developmental biology, who also helped lead the study. "The EBAX-containing protein-cleaning machine is in charge of destroying any irreparable products so that they don't hang around and affect the performance of functional receivers. The EBAX-1 protein plays as a defectiveness detector in this machine and a connector to Hsp90. It captures defective products and presents them for either repair or destruction." A human neurodevelopmental disorder called "horizontal gaze palsy with progressive scoliosis" is associated with the defective production of one of the protein guidance receivers. This team of researchers showed that the defective human protein can interact with EBAX proteins. The authors hope that by investigating the action of EBAX-1 protein, their findings will provide clues to develop remedies or drugs to retreat human disorders in the future.
|Contact: Kim McDonald|
University of California - San Diego