WORCESTER, Mass. In the quest to better understand how the brain chooses between competing behaviors necessary for survival, scientists at the University of Massachusetts Medical School and New York University have isolated two genes in the fruit fly Drosophila that work together to mediate the need to sleep and the need to eat. The study, which appears in the online version of Current Biology, offers insights that may be used to understand sleep-and metabolism-related disorders in humans.
"This work determines part of the neural mechanism that mediates a conflict in a hungry fly's brain in deciding whether to seek food or sleep," said Scott Waddell, PhD, associate professor of neurobiology. "It provides a foundation for understanding how the neural control of these two homeostatic behaviors is integrated in the brain." Previous research has shown that neural systems controlling sleep and feeding in mammals are interconnected: sleep deprivation promotes feeding, whereas starvation suppresses sleep, but little was known about the genes responsible for this interaction. Because the genes that make up Drosophila's internal clock have counterparts with similar functions in mammals, such as those controlling regulation of sleep and metabolism, the study of fruit fly genes can have implications for humans.
After initially screening around 2,000 genes, the researchers identified more than a dozen involved in the interaction between feeding and sleep. From this smaller group, they focused on the Clock and cycle genes, which play a role in both the fruit fly and mammalian circadian, or biological, clock.
To determine the impact of these two genes on the relationship between sleeping and feeding, the researchers examined fruit flies with and without the Clock and cycle genes under food deprivation conditionsthe flies were given only a liquid gel containing no nutrients over a 24-hour period and the researchers monitored the fl
|Contact: Jim Fessenden|
University of Massachusetts Medical School