Navigation Links
Biologists engineer algae to make complex anti-cancer 'designer' drug
Date:12/10/2012

Biologists at UC San Diego have succeeded in genetically engineering algae to produce a complex and expensive human therapeutic drug used to treat cancer.

Their achievement, detailed in a paper in this week's early online issue of The Proceedings of the National Academy of Sciences, opens the door for making these and other "designer" proteins in larger quantities and much more cheaply than can now be made from mammalian cells.

"Because we can make the exact same drug in algae, we have the opportunity to drive down the price down dramatically," said Stephen Mayfield, a professor of biology at UC San Diego and director of the San Diego Center for Algae Biotechnology or SD-CAB, a consortium of research institutions that is also working to develop new biofuels from algae. Their method could even be used to make novel complex designer drugs that can't be produced in any other systems--drugs that could be used to treat cancer or other human diseases in new ways.

"You can't make these drugs in bacteria, because bacteria are incapable of folding these proteins into these complex, three-dimensional shapes," said Mayfield. "And you can't make these proteins in mammalian cells because the toxin would kill them."

The advance is the culmination of seven years of work in Mayfield's laboratory to demonstrate that Chlamydomonas reinhardtii, a green alga used widely in biology laboratories as a genetic model organism, can produce a wide range of human therapeutic proteins in greater quantity and more cheaply than bacteria or mammalian cells.

Mayfield and his colleagues achieved their first breakthrough five years ago when they demonstrated they could produce a mammalian serum amyloid protein in algae. The following year, they succeeded in getting algae to produce a human antibody protein. In 2010, they demonstrated that more complex proteinshuman therapeutic drugs, such as human vascular endothelial growth factor, or VEGF, used to treat pati
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Biologists unlocking the secrets of plant defenses, 1 piece at a time
2. SF State biologists tag zombees to track their flight
3. New book on stereology by Mark West is essential reading for neurobiologists
4. UCLA biologists reveal potential fatal flaw in iconic sexual selection study
5. Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
6. Biologists turn back the clock to understand evolution of sex differences
7. University of Toronto biologists predict extinction for organisms with poor quality genes
8. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
9. American Society of Plant Biologists honors early career women scientists
10. Microbiologists can now measure extremely slow life
11. IU biologists offer clearer picture of how protein machine systems tweak gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... (Sept. 17, 2014) A rare genetic disorder known as ... a recent joint investigation by researchers at San Diego ... In addition to suggesting better treatment options for people ... into the genetic underpinnings of autism., Jacobsen syndrome affects ... Institutes of Health. It occurs in a person when ...
(Date:9/17/2014)... IMIM (Hospital del Mar Medical Research Institute) and at ... a study in eLife showing that RNA ... evolution of new proteins, some of which could have ... proteins from the instructions found in an RNA molecule. ... containing information for the synthesis of proteins, meaning it ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2A link between Jacobsen syndrome and autism 2Parts of genome without a known function may play a key role in the birth of new proteins 2
... video games can help to train the brain to become ... Queen Mary University of London and University College London (UCL). ... flexibility, described as a person,s ability to adapt and switch ... time to solve problems. Two groups of volunteers were ...
... drug and dietary supplement manufacturers are updating the tests used ... impurities, and the stringent new requirements, instruments and costs are ... of Chemical & Engineering News . C&EN is the ... scientific society. Ann Thayer, C&EN senior correspondent, explains that ...
... role in how people,s taste receptors send signals, leading ... Penn State food scientists. These varied, genetically influenced responses ... a range of artificial sweeteners to accommodate different consumer ... respond to tastes of foods," said John Hayes, assistant ...
Cached Biology News:Playing video games can boost brain power 2Multiple genes manage how people taste sweeteners 2
(Date:9/17/2014)... Hussey Copper , a leader in ... copper, announces Gilmour Academy Ice Arena,s conversion of more ... solid touch surface to help protect against bacteria.  MD-Cu ... that kills greater than 99.9% of MRSA, E-coli and ... , Innovative Gilmour Academy ...
(Date:9/17/2014)... , 17 de septiembre de 2014 /PRNewswire/ ... principal proveedor mundial de soluciones logísticas avanzadas ... de la vida, anunció hoy la contratación ... global con sede en Rótterdam, Países Bajos, ... clientes Europa en rápido crecimiento. Según los ...
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
(Date:9/16/2014)... 2014  Biocom, the association representing the ... 9 th Annual National Health Information Technology Week, ... in improving our health care system. ... the world,s most vibrant hubs for health IT and ... to genomic testing to remote patient monitoring," said ...
Breaking Biology Technology:Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Biocom Recognizes National Health IT Week 2
... Practical Implementation of ... Intra-Operative Imaging, NUREMBERG, Germany, October 13 ... at the beginning of,the year, Ziehm Imaging, provider of mobile x-ray ... provides,training in line with international standards, in order to keep its,partners ...
... SYDNEY, Australia, Oct. 13 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,Ltd (AXS: ... Quarterly,Report to Shareholders on the afternoon of Wednesday ... teleconference the following morning to,review the quarter and ... on Thursday 16th October at 8.30am (Sydney),(Wednesday 15th ...
... Oct. 10 Cell Therapeutics, Inc.,(CTI) (Nasdaq and ... to,request a hearing with the NASDAQ Listing Qualifications ... NASDAQ Marketplace Rule 4450(b)(1)(A),which requires a minimum market ... a Staff Determination Letter from The NASDAQ Stock ...
Cached Biology Technology:Ziehm Imaging Extends its Training Offer 2Ziehm Imaging Extends its Training Offer 3Ziehm Imaging Extends its Training Offer 4Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 2Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 3
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
Request Info...
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
...
Biology Products: