Navigation Links
Biologists' discovery may force revision of biology textbooks
Date:8/18/2011

Basic biology textbooks may need a bit of revising now that biologists at UC San Diego have discovered a never-before-noticed component of our basic genetic material.

According to the textbooks, chromatin, the natural state of DNA in the cell, is made up of nucleosomes. And nucleosomes are the basic repeating unit of chromatin.

When viewed by a high powered microscope, nucleosomes look like beads on a string (photo at right). But in the August 19th issue of the journal Molecular Cell, UC San Diego biologists report their discovery of a novel chromatin particle halfway between DNA and a nucleosome (photo at left). While it looks like a nucleosome, they say, it is in fact a distinct particle of its own.

"This novel particle was found as a precursor to a nucleosome," said James Kadonaga, a professor of biology at UC San Diego who headed the research team and calls the particle a "pre-nucleosome." "These findings suggest that it is necessary to reconsider what chromatin is. The pre-nucleosome is likely to be an important player in how our genetic material is duplicated and used."

The biologists say that while the pre-nucleosome may look something like a nucleosome under the microscope, biochemical tests have shown that it is in reality halfway between DNA and a nucleosome.

These pre-nucleosomes, the researchers say, are converted into nucleosomes by a motor protein that uses the energy molecule ATP (see graphic).

"The discovery of pre-nucleosomes suggests that much of chromatin, which has been generally presumed to consist only of nucleosomes, may be a mixture of nucleosomes and pre-nucleosomes," said Kadonaga. "So, this discovery may be the beginning of a revolution in our understanding of what chromatin is."

"The packaging of DNA with histone proteins to form chromatin helps stabilize chromosomes and plays an important role in regulating gene activities and DNA replication," said Anthony Carter, wh
'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Team led by IU biologists confirms sunflower domesticated in US, not Mexico
2. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
3. Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge
4. Cell biologists hail stem cell decision
5. Software helps synthetic biologists customize protein production
6. Biologists discover an evening protein complex that regulates plant growth
7. Purdue biologists identify new strategy used by bacteria during infection
8. New curation tool a boon for genetic biologists
9. 2 UC Davis plant biologists named as HHMI-GBMF investigators
10. Announcing BIOLOGY OPEN from the Company of Biologists
11. Manage biological invasions like natural disasters, biologists say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... Conn. , Jan. 26, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... new corporate website ( http://www.nxt-id.com/ ) as part of ... smart wallet. The Company launched its new consumer website ... Gino Pereira , CEO of NXT-ID said, "Our new ...
(Date:2/5/2015)... Conn. , Jan. 28, 2015 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... at the upcoming RedChip Global Online CEO Conference on ... Gino Pereira , CEO of NXT-ID ... its lead product, the Wocket smart wallet and its ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... , NEW YORK (February 24, 2012) A new ... Society, and others uses a new scientific methodology for ... "diversified portfolio" of management options from strict no-take ... methodology looks at existing information on the country,s climate, ...
... -- Neither births nor deaths stop the flocking of organisms. ... of the University of Oregon. The notion, he says, has ... therapies. Picture any scenario in which self-propelled organisms -- ... even tiny plastic rods on a vibrating table -- move ...
... saved an iconic Australian lizard species from death at the ... the March issue of The American Naturalist . It,s ... for the arrival of another, says Richard Shine, a biologist ... Cane toads were introduced in Australia in the ...
Cached Biology News:Study IDs new marine protected areas in Madagascar 2New theory shows that neither birth nor death stops a flock 2New theory shows that neither birth nor death stops a flock 3Invasive plant protects Australian lizards from invasive toad: Study 2
(Date:2/27/2015)... CAMBRIDGE, Mass. , Feb. 27, 2015 /PRNewswire-USNewswire/ ... Analysis of the NCATS rare-diseases portfolio " in ... of a new financing technique to reduce the ... new diseases and potentially unlock new levels of ... The product of a unique collaboration between ...
(Date:2/27/2015)... 2015 Bionomics Limited (ASX:BNO, ADR:BMICY) is to ... BNC105 in patients with metastatic renal cancer at the ... . The data will be presented by Dr. ... Comprehensive Cancer Center in California ... data identifies Ferritin and IL-8 as two baseline biomarkers ...
(Date:2/27/2015)...  Steep Hill, the industry leader in cannabis testing ... open a full service medical cannabis quality assurance laboratory ... advanced scientific tools and methodology to the state, for ... currently the only laboratory licensed by the New Mexico ... in order to meet the recently adopted regulatory requirements ...
(Date:2/26/2015)... , Feb. 26, 2015  23andMe, the leading personal ... Black as Privacy Officer and Corporate Counsel. Black ... privacy laws as well as health care regulations. As ... will be responsible for reviewing, updating and enhancing the ... U.S. and abroad. She joined the company January 5, ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 223andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
... researchers have developed new technology capable of removing ... efforts following nuclear disasters. The innovation could ... up millions of tonnes of water contaminated by ... waste. Professor Huai-Yong Zhu from QUT Chemistry ...
... DIEGO, Nov. 2, 2011 Cadence Pharmaceuticals, Inc. (NASDAQ: ... in-licensing, developing and commercializing proprietary products principally for use ... President and CEO Ted Schroeder will present the company,s ... Mountain Time (3:30pm Eastern Time) during the Credit Suisse ...
... Axia Value Chain, a market leader in business transformation ... their Life Sciences and Health Care Practice Group. In ... global clients in the Health Care and Life Science ... practice development, and service offerings concentrating on alignment of ...
Cached Biology Technology:Technology makes storing radioactive waste safer 2Axia Value Chain Appoints John Christina Managing Director of Life Sciences Practice 2
... specificity and signaling of the members of ... modified by alternative splicing--which has important implications ... can perform a classical expression profiling and ... alternatively spliced forms of the gene that ...
... Alternative Splicing plays an important role in ... apoptosis and cell death. Splice variants have ... and inhibition of defined apoptotic pathways. With ... can perform a classical expression profiling and ...
... Workstation is a modular, highly scalable, automated ... 1ml or 3ml industry standard SPE cartridges, ... samples in less than two hours unattended. ... cartridges, and up to 10 modules can ...
... evolutionarily conserved form of cell suicide, which ... central component of this process is a ... These enzymes participate in a series of ... pro-apoptotic signals and result in the cleavage ...
Biology Products: