Navigation Links
Biologists at UC San Diego identify key protein in cell's 'self-eating' function
Date:3/11/2008

Molecular biologists at the University of California, San Diego have found one piece of the complex puzzle of autophagy, the process of self-eating performed by all eukaryotic cells -- cells with a nucleus -- to keep themselves healthy.

Their finding, published in the March 11 issue of the journal Developmental Cell, is important because it allows scientists to control this one aspect of cellular autophagy, and may lead to the ability to control other selective self-eating processes. This, in turn, could help illuminate autophagys role in aging, immunity, neurodegeneration and cancer.

All eukaryotic cells dispose of bacteria, viruses, damaged organelles and other non-essential components through this self-eating process. A part of the cell called the lysosome engulfs and degrades subcellular detritus. The ability of cells to recycle and reuse the cellular raw materials, as well as to re-model themselves in response to changing conditions, allows them to adapt and survive.

Autophagy was first described about 40 years ago, but has recently become a topic of great interest in cell biology because it is linked to cell growth, development aging and homeostasis -- helping cells to maintain a balance among synthesis, degradation and recycling.

The UC San Diego researchers report in their paper that they identified a novel protein called Atg30 (one of 31 required for autophagy-related processes) from the yeast Pichia pastoris, that controls the degradation of a sub-compartment of cells, the peroxisomes.

Peroxisomes generate and dispose of harmful peroxides that are by-products of oxidative chemical reactions.

Different organelles within the cell are degraded by lysosomes when the organelles are damaged or not necessary, said Jean-Claude Farr, the biologist who identified Atg30. The team is investigating peroxisomes, and working to understand how and why they are selected by the lysosome for degradation.

Wha
'/>"/>

Contact: Paul K. Mueller
pkmueller@ucsd.edu
858-534-8564
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. The American Society of Plant Biologists announces 2007 awards
2. Biologists expose hidden costs of firefly flashes
3. Tufts University biologists link Huntingtons disease to health benefits in young
4. UD plant biologists uncover top wetland plants hidden weapon
5. Evolution is deterministic, not random, biologists conclude from multi-species study
6. Biologists find unusual plant gene: abstinence by mutual consent
7. Ant parasite turns host into ripe red berry, biologists discover
8. Cell biologists announce child-care grants for scientist-parents at annual meeting
9. Biologists surprised to find parochial bacterial viruses
10. UC San Diego physicists tackle knotty puzzle
11. UC-San Diego Engineering Honor Society wins most outstanding chapter award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 16, 2015  A man-made form of insulin delivered ... mental capabilities in adults with mild cognitive impairment and ... by researchers at Wake Forest Baptist Medical Center. ... amnesic mild cognitive impairment (MCI) or mild to moderate ...
(Date:1/22/2015)... NEW YORK and POINT ROBERTS, Washington ... global news source covering leading sectors including technology and tech ... Personal Privacy marketplace featuring master pickpocket and security consultant ... wallet is stolen and talks about the Wocket™ biometric smart ...
(Date:1/22/2015)... , Europe,s most ... Patent Office to present a video retrospective of the most exciting ... Christofer Toumazou and Sophie Wilson   ... the Award   Starting on 22 January 2015 on   ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... corn, 1 + 1 = more than 2: The offspring ... of their parents. Characterizing the gene-level variability that leads to ... our ability to custom-tailor crops for specific traits, such as ... for biomass fuel. With help from the newly ...
... A team of researchers at Louisiana Tech University ... a natural herbicide against giant salvinia. Giant salvinia ... block all sunlight penetration into bodies of water, altering ... that giant salvinia can double in size every three ...
... - A new study of maize has identified thousands of ... techniques may allow breeders and researchers to use this genetic ... were not easily possible before. Publishing in the Nov. ... and first author are at Cornell, have identified the first ...
Cached Biology News:U of M plant scientist uncovers clues to yield-boosting quirks of corn genome 2Microorganism may provide key to combating giant salvinia throughout Louisiana 2New map of variation in maize genetics holds promise for developing new varieties 2
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... GenoSpace , a precision medicine software company that has developed ... of genomic, imaging and other biomedical data in research and ... , CEO of Aspera, an IBM Company, to its board ... "We are pleased to welcome Michelle ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... FRANCISCO, Calif., May 5 Rigel Pharmaceuticals, Inc. (Nasdaq: ... quarter ended March 31, 2009.For the first quarter of 2009, ... per share, compared to a net loss of $27.3 million, ... Weighted average shares outstanding for the first quarters of 2009 ...
... Uveitis, or inflammation within the eye, is a ... loss roughly comparable to that caused by diabetes. ... program in uveitis, the LUMINATE trials sponsored by ... voclosporin oral capsule) to significantly improve this chronic ...
... The Arcas Group, a leading life-sciences marketing ... as Executive Vice President. He will assume responsibility for ... as President of Imedex, Inc."Stefan is an experienced executive ... our company," said Founder and President Jan Heybroek. ...
Cached Biology Technology:Rigel Announces First Quarter 2009 Financial Results 2Rigel Announces First Quarter 2009 Financial Results 3Rigel Announces First Quarter 2009 Financial Results 4Rigel Announces First Quarter 2009 Financial Results 5First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 2First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 3First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 4The Arcas Group Appoints Executive Vice President 2
... Lipid adsorption and clarification reagent; Ideal ... purification of antibodies, proteins, nucleic acids, ... negligible cross-reactivity, and improves downstream processing; ... solid-phase, non-ionic adsorbent supplied as a ...
... is designed to stabilize the biomolecules ... storage. There are neither animal ... is a convenient 10 times solution ... superior to other traditional lyophilizing additives ...
... is the only Gradient thermal cycler which enables ... of a screen. ,Wide linear gradient - ... with an amazing range of,30C. Protocols can be ... - The Touchgene Gradient incorporates a large, 115 ...
... is Tecans open platform for clinical diagnostic ... and performance in the clinical diagnostic and ... flexible barcode reading and sample traceability as ... system complies with the IVD-Directive* established in ...
Biology Products: