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Biologistics: How fast do chemical trains move in living cells?
Date:1/31/2013

sity and macroscopic viscosity, and a few dozens of diffusion coefficients of macromolecules in Escherichia coli taken from the literature. This was a basis for construction of a scale-dependent viscosity reference curve that could be used to determine diffusion coefficients of remaining compounds.

The database constructed at the IPC PAS contains diffusion coefficients for complete proteome of Escherichia coli. It includes over 6000 macromolecules, with about 4300 gene-expressed amino acid chains and their various, often multiple combinations (polymers), created both by the same chains (homomers), and by different amino acids (heteromers).

"Because of easy access to the literature data, we created a database only for molecules occurring in Escherichia coli. Our method could be, however, adapted for virtually any cell and every molecule, for instance for determining diffusion coefficients of sugars in mammalian cells", stresses Dr Marcin Tabaka (IPC PAS).


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Contact: Robert Hoyst
rholyst@ichf.edu.pl
48-223-433-123
Institute of Physical Chemistry of the Polish Academy of Sciences
Source:Eurekalert  

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