Navigation Links
Biological warfare in bacteria offers hope for new antibiotics
Date:7/2/2009

Scientists are to study a group of proteins that are highly effective at killing bacteria and which could hold the key to developing new types of antibiotics.

Researchers from the Universities of York and Leeds have been awarded 3.3m from the Biotechnology and Biological Sciences Research Council (BBSRC) to find out how a family of proteins known as colicins force their way into bacterial cells before destroying them.

The team, led by Professor Colin Kleanthous, from the University of York's Department of Biology, will develop earlier research that suggests colicins use decoys to mimic key parts of the cells' own protein machinery to evade their defences.

Professor Kleanthous said: "Colicins are the weapon used in the biological warfare that takes place between competing bacteria. Understanding how this group of proteins work could help scientists develop new drug delivery methods to target the bacteria that cause diseases in people."

"It's as though the colicins are carrying the equivalent of hand grenades which they can deploy without harming themselves," said Professor Sheena Radford of the University of Leeds' Faculty of Biological Sciences.

The five year programme of research aims to discover how colicins specifically penetrate Gram-negative bacteria which are protected by two membrane barriers.

It will involve collaboration between six groups of scientists from the Departments of Biology and Chemistry at the University of York and the Astbury Centre for Structural and Molecular Biology, Faculty of Biological Sciences, at the University of Leeds.


'/>"/>

Contact: James Reed
jr576@york.ac.uk
44-019-044-32029
University of York
Source:Eurekalert

Page: 1

Related biology news :

1. Keck Foundation funds study of biological interactions with nanomaterials
2. New insight into the mechanisms of voltage sensing and transduction in biological processes
3. Biological warfare: What do you need to know?
4. A mechanism to explain biological cross-talk between 24-hour body cycle and metabolism
5. Story ideas from the Journal of Biological Chemistry
6. Emerging field of neuroecology is showcased in December issue of the Biological Bulletin
7. Story ideas from the Journal of Biological Chemistry
8. Systems biologist finds novel solutions to fundamental biological problems
9. MIT applies engineering approach to studying biological pathways
10. Lensless camera uses X-rays to view nanoscale materials and biological specimens
11. Systems biology approach identifies nutrient regulation of biological clock in plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 2017 , ... RMC Pharmaceutical Solutions, Inc. announces the opening ... manage the new site. , Tim has 25 years of pharmaceutical experience, including ... as the Director of Manufacturing and Supplier Quality Assessment. This group is ...
(Date:6/22/2017)... ... 22, 2017 , ... For the months of May and ... Spotlight series on “Cell Therapy Regulation” for its regenerative medicine followship. ... unique regulatory challenges of stem cell medical research. , Stem cell clinical trials ...
(Date:6/22/2017)... , ... June 22, 2017 , ... Charm Sciences, Inc. ... The AMPH test was determined to be appropriate as a screening test at dairies ... on the Charm EZ system, and the Charm EZ Lite system. These systems are ...
(Date:6/20/2017)... , June 20, 2017  Kibow Biotech Inc., ... to announce the issuance of a new patent covering ... hyperuricemia by the U.S. Patent and Trademark Office on ... winner of the Buzz of Bio award in 2014 ... akin to developing non-drug approaches to chronic disease. Renadyl™, ...
Breaking Biology Technology: