Navigation Links
Biological therapy with cediranib improves survival in women with recurrent ovarian cancer
Date:9/30/2013

king data," said Prof Ledermann. "Cediranib is the first oral VEGF tyrosine kinase inhibitor that has been shown to delay tumour progression and improve overall survival in recurrent ovarian cancer. It is simple to give for a prolonged period and in most patients it is well-tolerated." Adverse side-effects included high blood pressure, diarrhoea and fatigue.

A total of 456 patients whose ovarian cancer had recurred were enrolled in the trial in 63 centres from the UK, Canada, Australasia and Spain. They were randomised to receive platinum-based chemotherapy together with a placebo (the reference arm of the trial), or 20 mg a day of cediranib during chemotherapy followed by placebo for 18 months (concurrent arm of the trial), or 20 mg a day of cediranib during chemotherapy followed by cediranib as a maintenance treatment (maintenance arm).

"ICON6 has a three-arm design in which the effect of cediranib given with chemotherapy and continued as maintenance can be compared with standard chemotherapy. This is the first trial to have demonstrated a benefit of concurrent cediranib with chemotherapy, as well as demonstrating an additional benefit with maintenance cediranib," he said.

An increased survival time of nearly three months is significant in this group of patients. Prof Ledermann explained: "In previous ovarian cancer trials any improvement seen with each new treatment has been incremental. Survival has improved through sequential use of drugs. Most of the recent positive trials have shown an improvement in progression-free survival. Trials showing an improvement in overall survival are uncommon. Cediranib produces an incremental improvement in progression-free survival and an incremental improvement in overall survival. Although the average improvement in overall survival is 2.7 months, some patients will see a much more substantial benefit."

ECCO president, Professor Cornelis van de Velde, commented: "These are important resul
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Religious leaders can be key to biological diversity
2. Single-cell transfection tool enables added control for biological studies
3. Biological activity alters the ability of sea spray to seed clouds
4. Epigenetic changes shed light on biological mechanism of autism
5. PeerJ launches PeerJ PrePrints -- a preprint server for the biological and medical sciences
6. Declaring a truce with our microbiological frienemies
7. UMass Amherst researchers reveal mechanism of novel biological electron transfer
8. Biological wires carry electricity thanks to special amino acids
9. Wayne State University researchers techniques enable more, faster testing of biological liquids
10. Snooze button on biological clocks improves cell adaptability
11. Advance promises to expand biological control of crop pests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... an injury can probably remember the after-effects, including pain, ... is fighting back against the injury. When tissue in ... aid in tissue regeneration. An inflammatory response acts as ... the body to heal after injuries such as wounds ... healing in situations in which foreign material is introduced, ...
(Date:8/22/2014)... comprehensive study of captive black rhino reproduction in ... success of breeding programmes. , Researchers from Chester ... of Liverpool carried out a six-year study which ... , Dr Katie Edwards led the research as ... Liverpool. She says: "Although some black rhinoceros breed ...
(Date:8/22/2014)... will finally be able to purchase fuel cell cars ... vehicles, most of the cars will run on hydrogen ... to global warming. , Now scientists at Stanford University ... ordinary AAA battery to produce hydrogen by water electrolysis. ... electrodes that split liquid water into hydrogen and oxygen ...
Breaking Biology News(10 mins):Tissue regeneration using anti-inflammatory nanomolecules 2Hormone analysis helps identify horny rhinos 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... release is available in German . ... travel of tomorrow is meant to become quieter, cleaner and ... to accomplish just that as part of the EU ... technical aspects of air travel to the test, evaluating and ...
... available in French . Quebec ... in which a breastfed premature infant remains in skin-to-skin ... in an incubator -- has lasting positive impact on ... issue of Acta Paediatrica. Very premature infants who benefited ...
... November 11-14, 2012 WHERE: The Knoxville ... 2012 is the 60th Annual Meeting of the Entomological Society ... attend. The theme is "A Global Society for a Global ... 2,500 presentations on subjects such as bed bugs, honey bees, ...
Cached Biology News:Fraunhofer supports continuation of 'Clean Sky' program 2Preemies' brains reap long-term benefits from Kangaroo Mother Care 2
(Date:8/22/2014)... (August 22nd), in the scientific journal PLoS ... establish the effect of serotonin on sensitivity to ... optical techniques., "Serotonin is a small molecule known ... brain functions, from the control of sleep and ... This neurotransmitter is also popularly thought to contribute ...
(Date:8/22/2014)... , Aug. 22, 2014 Research ... "Global and China Gel Permeation Chromatography (GPC) Industry ... The Global and China Gel Permeation Chromatography (GPC) ... the current state of the global gel permeation chromatography ... The report provides a basic overview of the industry ...
(Date:8/22/2014)... SC (PRWEB) August 22, 2014 ... indisputable acknowledgement is a national disgrace. Furthermore, every ... in establishing the current, deplorable state of unorganized ... "5 great mistakes," to merely serve as a ... the extent of colossal failure(s) that have accumulated ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 25 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... 15 Senetek PLC,(OTC Bulletin Board: SNKTY), a Life ... the science of healthy aging, today,announced an agreement with ... Sciences in Poznan, Poland for the exclusive rights to ... therapeutic technology for,the potential use against a broad range ...
... 15 bwin, the world,s,leading online gaming company, and ... Harvard Medical School Teaching Affiliate, have,just signed an agreement ... to use scientific evidence to create the safest,possible online ... longitudinal study. , ...
... ProGenTech Limited was a winner of the Red Herring 100 Award, ... Asia. , The Red Herring ... top 100 out of more than 1,000,closely evaluated companies that are ... "It is truly an honor to be recognized by ...
Cached Biology Technology:Senetek PLC Acquires Rights to Additional Anticancer RNAi Technology 2bwin and Harvard Medical School Faculty Sign 5-Year Research Cooperation Agreement 2Red Herring Awards ProGenTech Limited for the 2008 Red Herring Asia 100 2
Recorder, 6", 7 Day, 1 Pen, 0 to 100°C, 220V, 50/60 Hz, for 4520, Customer Installed...
... COPS2 is an essential component of ... involved in various cellular and developmental processes. ... of the ubiquitin (Ubl) conjugation pathway by ... of SCF-type E3 ligase complexes. The complex ...
... Ambions 96 well Magnetic-Ring Stand is designed ... well U-bottom microplates. The stand has a ... well microtiter plate footprint. The use of ... fast and easy magnetic separation. With this ...
6B9...
Biology Products: