Navigation Links
Biological signal processing: Body cells -- instrumentalists in a symphony orchestra
Date:7/3/2014

Every organism has one aim: to survive. Its body cells all work in concert to keep it alive. They do so through finely tuned means of communication. Together with cooperation partners from Berlin and Cambridge, scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have now successfully revealed for the first time the laws by which cells translate signals from their surroundings into internal signals. Like an isolated note in a symphony orchestra, an isolated signal in the cell is of subordinate importance. "What is important is the relative variation of intensity and frequency at which the signals are transmitted from the cell membrane into the cell," says Dr. Alexander Skupin, who led the studies at LCSB. The research group published their results now in the scientific journal Science Signaling (DOI: 10.1126/scisignal.2005237).

The instruments in an orchestra produce signals musical notes by causing the air to vibrate. Inside a cell, calcium ions carry signals. When a piece of information from the environment say a biological messenger meets the outer envelope of the cell, calcium ions are released inside the cell. There, they control various adaptation processes. "At first sight, there is no simple pattern to the ion impulses," Skupin explains; "yet they still culminate in a meaningful response inside the cell, like the activation of a specific gene, for instance."

In order to determine the laws underlying this phenomenon, the researchers studied human kidney cells and rat liver cells using a combination of imaging technologies and mathematical methods. They discovered that the intensity and frequency of calcium impulses undergo extreme variation both cell-internally and cell-to-cell. Accordingly, the information they convey cannot be interpreted by analyzing isolated signals alone. "It's like in an orchestra, where studying an isolated note on its own allows no inference of the melody," Skupin continues the musical analogy. "You have to hear how the frequency and volume of all instruments vary and produce the melody. Then you gain an impression of the musical piece."

Now, for the first time, the researchers have managed to gain such an impression of the whole by listening in on the cells' communications. They discovered that the plethora of calcium impulses vary relatively to one another in a specific relationship: A stimulus from outside does not lead to an absolute increase in calcium impulses, but instead to a change in the frequency at which they occur in the concert hall, the notes of the instruments rise and fall in symphony. "This pattern is the actual signal that leads to a response in the cells," Skupin says. "With our analyses, we have rendered it interpretable."

"The results are of great importance for analyzing diseases," says Director of LCSB Prof. Dr. Rudi Balling. "We know that, in Parkinson's disease, the calcium balance in the nerve cells is disrupted, and suspect that errant communications between the cells could play a role in the onset of neurodegenerative diseases. With the discovery of the fundamental laws of these communications, as Alexander Skupin, his team and our cooperation partners have now achieved, we are set to take a major step forward in the analysis of Parkinson's disease."


'/>"/>

Contact: Britta Schlüter
britta.schlueter@uni.lu
352-466-644-6563
University of Luxembourg
Source:Eurekalert  

Related biology news :

1. A first: Scientists show bacteria can evolve a biological timer to survive antibiotics
2. Fruit fly research to provide new insight into our body clock and its biological impact
3. Bottom trawling causes deep-sea biological desertification
4. National Academy of Sciences elects 5 from UChicago, Marine Biological Laboratory
5. New atom-scale knowledge on the function of biological photosensors
6. Biological testing tool, ScanDrop, tests in fraction of time and cost of industry standard
7. Research findings link post-heart attack biological events that provide cardioprotection
8. New biological scaffold offers promising foundation for engineered tissues
9. First biological marker for major depression could enable better diagnosis and treatment
10. Scientists turn primitive artificial cell into complex biological materials
11. New study may aid rearing of stink bugs for biological control
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biological signal processing: Body cells -- instrumentalists in a symphony orchestra
(Date:2/11/2016)... -- Vigilant Solutions announces today that its license plate recognition (LPR) ... Lee,s Summit Police Department to improve safety ... a homicide suspect. Kansas City , ... miles and is home to roughly 100,000 residents. ... license plate reader system and also leverages Vigilant,s network of ...
(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ... "Global Facial Recognition Market 2016-2020" ... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the addition of ... report to their offering. --> ... has announced the addition of the ...
(Date:2/3/2016)... , Feb. 3, 2016 ... addition of the "Emotion Detection and ... Learning, and Others), Software Tools (Facial Expression, ... End Users,and Regions - Global forecast to ... --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... is introducing a hybrid membership model which will provide ... joining or renewing through an organizational purchasing model. For ... employee in any size association or AMC office can ... benefits.   John H. Graham, IV , ... organizations of any size and their employees to gain ...
(Date:2/10/2016)... Feb. 10, 2016  Matchbook, Inc., a company ... growing biotech companies, announced today the appointment of ... Advisor. Jim brings nearly 25 years of experience ... having spent nearly two decades in executive level ... Procurement at Genzyme and, most recently headed global ...
(Date:2/10/2016)... ... 2016 , ... SonaCare Medical, LLC reports the introduction of ... monitoring. The inaugural launch of this new technology occurred over the course of ... to a HIFU technical expert at SonaCare Medical headquarters. , Sonalink allows ...
(Date:2/10/2016)... ... 10, 2016 , ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused on ... today it has been selected to present at the Cavendish Global Health Impact Forum ... The purpose of the Forum is to help family offices and foundations develop ...
Breaking Biology Technology: