Navigation Links
Biological link between stress, anxiety and depression identified for the first time
Date:4/11/2010

Scientists at The University of Western Ontario have discovered the biological link between stress, anxiety and depression. By identifying the connecting mechanism in the brain, this high impact research led by Stephen Ferguson of Robarts Research Institute shows exactly how stress and anxiety could lead to depression. The study also reveals a small molecule inhibitor developed by Ferguson, which may provide a new and better way to treat anxiety, depression and other related disorders. The findings are published online in the journal Nature Neuroscience.

Ferguson, Ana Magalhaes and their colleagues used a behavioural mouse model and a series of molecular experiments to reveal the connection pathway and to test the new inhibitor. "Our findings suggest there may be an entire new generation drugs and drug targets that can be used to selectively target depression, and therefore treat it more effectively, " says Ferguson, the director of the Molecular Brain Research Group at Robarts, and a professor in the Department of Physiology & Pharmacology at Western's Schulich School of Medicine & Dentistry. "We've gone from mechanism to mouse, and the next step is to see whether or not we can take the inhibitor we developed, and turn it into a pharmaceutical agent."

The research was conducted in collaboration with Hymie Anisman at Carleton University, and funded through the Canadian Institutes of Health Research (CIHR). "According to the World Health Organization, depression, anxiety and other related mood disorders now share the dubious distinction of being the most prevalent causes of chronic illness," says Anthony Phillips, the scientific director of the CIHR Institute of Neurosciences, Mental Health and Addiction. "Using the power of molecular biology, Stephen Ferguson and colleagues provide novel insights that may be the key to improving the lives of so many individuals coping with these forms of mental ill health."

The linki
'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Page: 1 2

Related biology news :

1. Multifunctional polymer neutralizes both biological and chemical weapons
2. Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket
3. $25M NSF center established to investigate the creation of biological machines
4. Engineer studies tensional integrity of biological structures
5. Scientists identify first genetic variant linked to biological aging in humans
6. New study: Human running speeds of 35 to 40 mph may be biologically possible
7. From biological basics to diabetes discovery
8. Seeing how evolutionary mechanisms yield biological diversity
9. New biological route for swine flu to human infections
10. Researchers discover biological basis of bacterial immune system
11. Dr. William Brody, President of the Salk Institute for Biological Studies, Appointed to GenVaults Board of Directors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... business incubator, received a $1.4 million federal grant to ... staunch bleeding during brain surgery. , Surgeons can spray ... bio-polymer solutions in the gel will cohere and control ... The gel can shorten an intracranial surgery by 30- ... the patient,s skull to be open and less anesthesia, ...
(Date:7/10/2014)... State University have developed a small, portable and ... over the world better understand the radiation around them, ... poses a health risk. , The device was developed ... incident in Fukushima, Japan, in 2011, when many regional ... being exposed to and whether their homes, food, environment ...
(Date:7/10/2014)... Research Centre (CNIO) Macromolecular Crystallography Group has managed ... BuD to DNA in order to redirect it ... who led the study, says the discovery: "will ... contained in the genome to treat genetic diseases ... published in the journal Acta Crystallographica, Section ...
Breaking Biology News(10 mins):A start-up at NJIT develops bleeding-control gel for brain surgery 2Sophisticated radiation detector designed for broad public use 2Sophisticated radiation detector designed for broad public use 3CNIO scientists develop technology to redirect proteins towards specific areas of the genome 2
... journal Journal of Neuroinflammation suggests that chronic ... To date it has been difficult to ... (AD), especially because trials of NSAIDs appeared to have ... Prevention Trial) trial was stopped early, recent results suggest ...
... (July 1, 2012)For eastern Pacific populations of leatherback turtles, ... suggests that climate change could exacerbate existing threats and ... and hatchlings in nests buried at hotter, drier beaches ... decline, according to a new study in the journal ...
... some end up with chronic pain while others recover and ... track participants with a new back injury has found the ... A new Northwestern Medicine study shows for the ... of the brain --- related to emotional and motivational behavior ...
Cached Biology News:Rising heat at the beach threatens largest sea turtles, climate change models show 2Rising heat at the beach threatens largest sea turtles, climate change models show 3Why chronic pain is all in your head 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
(Date:1/14/2014)... Calif. , Jan. 14, 2014 As pet owners drew ... doubt many of them wrote: "Take better care of my furry ... even designer clothes and top-brand carrying cases to take the little ... parents might also feel compelled to buy some pricey toys at ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... Jan. 14, 2014   Kinaxis ®, provider of RapidResponse ... sales and operations planning ( S&OP ) service, is proud ... , which will be held at the Hilton San Diego ... Kinaxis customer Elisabeth Kaszas , Director of Supply Chain ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... today congratulated,growers planting Pioneer(R) brand sorghum hybrids who ... the 2007 National Sorghum Producers, (NSP),Yield and Management ... sorghum,hybrid 84G62., Farmers growing Pioneer sorghum hybrids ... First-, second- and third-place national,honors were awarded in ...
... Pharmos Corporation,(Nasdaq: PARS ) announced today ... resign from the Company., Mr. Rubino joined ... the,strategic acquisition and the subsequent integration of Vela,Pharmaceuticals ... Rubino has been focused on key business development ...
... Dec. 18 Trust for America,s,Health (TFAH) today ... the,Public,s Health from Disease, Disasters, and Bioterrorism" report, ... critical areas of the,nation,s emergency health preparedness effort ... annual cuts in federal funding for state,and local ...
Cached Biology Technology:DuPont Congratulates Growers Planting Pioneer(R) Brand Sorghum Hybrids in Winning Majority of National Categories in Yield Contest 2Pharmos Corporation Announces President & COO Alan L. Rubino to Leave Company 2Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 2Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 3Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 4Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 5
... Analyzer for superior sensitivity, mass accuracy, and resolving power., Specifications:, ... ion selection range: 150 - 4000 m/z, * Resolution: 14,000 (1400 ... * Dynamic range: 4 orders of magnitude ... ...
... M (OSM) is a pleiotropic cytokine produced ... sarcoma cells. OSM inhibits the growth of ... fibroblast, smooth muscle and Kaposis sarcoma cell ... low density lipoprotein receptor expression on hepatoma ...
... trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl ... latanoprost-related isomer containing both a double ... (β) hydroxyl group at C-15. Similar ... ester is a potential impurity in ...
ACS Reagent Grade C 19 H 14 O 5 S Formula Weight: 354.38 PRODUCT SPECIFICATIONS Form: Rust/red crystalline powder Clarity of Solution: Passes test Visual Transition Interval: pH 6.8 - Yellow pH 8.2...
Biology Products: