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Biological circuits for synthetic biology
Date:5/26/2011

engineering of programmable genetic networks. In recent years, scientists have learned that the behavior of cells is often governed by multiple different genes working together in networked teams that are regulated through RNA-based mechanisms. Synthetic biologists have been using RNA regulatory mechanisms to program genetic networks in cells to achieve specific results. However, to date these programming efforts have required proteins to propagate RNA regulatory signals. This can pose problems because one of the primary goals of synthetic biology is to create families of standard genetic parts that can be combined to create biological circuits with behaviors that are to some extent predictable. Proteins can be difficult to design and predict. They also add a layer of complexity to biological circuits that can delay and slow the dynamics of the circuit's responses.

"We're now able to eliminate the protein requirement and directly propagate regulatory signals as RNA molecules," Arkin says.

Working with their own variations of RNA transcription attenuators - nucleotide sequences that under a specific set of conditions will stop the RNA transcription process - Arkin and his colleagues engineered a system in which these independent attenuators can be configured to sense RNA input and synthesize RNA output signals. These variant RNA attenuators can also be configured to regulate multiple genes in the same cell and - through the controlled expression of these genes - perform logic operations.

"We have demonstrated the ability to construct with minimal changes orthogonal variants of natural RNA transcription attenuators that function more or less homogeneously in a single regulatory system, and we have shown that the composition of this system is predictable," Arkin says. "This is the first time that the three regulatory features of our system, which are all properties featured in a semiconductor transistor, have been captured in a single
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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

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