Navigation Links
Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
Date:11/16/2010

cells would also serve as excellent model systems for systematically studying cell function, signaling pathways, disease progression, and tissue growth and development.

Multifunctional Gel Matrix

The stem cells are embedded in a gelatin-like hydrogel bathed in an electrolyte solution compatible for cell growth. When an electric potential passes through the hydrogel, the gel bends and exerts mechanical strain on the cells that is designed to mimic the mechanical cues stem cells experience in natural microenvironments.

"Our hydrogel provides the chemical cues, and when you expose them to an electric field, the hydrogel surrounding the stem cells bends, which provides mechanical strain to the cells," said Varghese.

In the new paper, the bioengineers report results of human bone marrow derived mesenchymal stem cells growing in the new microenvironment. The chemical, electrical, and mechanical cues steered the embedded cells to differentiate into cartilage cells.

The researchers continue to improve their system, with the goal of coaxing healthy tissue from stem cells. "The ultimate goal of regenerative medicine is to make healthy tissues and differentiated cells with regenerating ability that can save lives. We are not there yet, but this work takes us one step closer," said Varghese, who is a faculty member of the UC San Diego Institute of Engineering in Medicine.

In addition, the work will be useful to researchers involved in basic stem cell research as well as stem-cell-based clinical trials. For example, in current clinical trials involving human stem cells, the cells are often conditioned in an artificial environment so that when they are implanted into humans, they are more apt to differentiate into the right kinds of cells. Additional control over the cues the cells receive during this conditioning phase could be critical to future regenerative therapy successes.

Crucial Undergraduate
'/>"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UC San Diego bioengineers fill holes in science of cellular self-organization
2. New method developed by UC San Diego bioengineers gives regenerative medicine a boost
3. Bioengineers succeed in producing plastic without the use of fossil fuels
4. Penn bioengineers create simulator to test blood platelets in virtual heart attacks
5. Entrust, 3M Collaborate to Provide End-to-End Secure ePassport Solution
6. Anabolic steroids provide a competitive edge in power lifting years after doping has ended
7. Paleozoic sediment curve provides new tool for tracking sea-floor sediment movements
8. Field Museum provides gold standard for mammal survey
9. Study provides insight on a common heart rhythm disorder
10. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
11. Brain structure provides key to unraveling function of bizarre dinosaur crests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... firm, is pleased to announce the promotion of ... Director of Digital Forensics. In Schiff,s new role as ... the team of digital forensics examiners and provide leadership ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... Calif. , Nov. 7, 2014  In conjunction with ... Police Departments, The Community Foundation of the Verdugos ... DNA JUSTICE PROJECT," a $250,000 initiative to keep ... initial phase. In its first six months of existence, the ... needed evidence support for local law enforcement. "Because ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... A paleontological team that includes scientists from the American ... and Case Western Reserve University has described two ancient ... a discovery that substantiates what might be the earliest ... near a chain of volcanoes about 32.5 million years ...
... new and powerful class of antioxidants could one day be ... class of antioxidants called synthetic triterpenoids blocked development of Parkinson,s ... handful of days, said Dr. Bobby Thomas, neuroscientist at the ... corresponding author of the study in the journal Antioxidants ...
... July 23, 2012 Scientists have embarked on a 3-week ... Mexico to understand how surface ocean currents near the site ... oil/dispersants, like those from the 2010 spill. In other words, ... get there. This experiment is an essential step in understanding ...
Cached Biology News:New species of ancient rodents hint at what could be world's oldest grasslands 2New species of ancient rodents hint at what could be world's oldest grasslands 3Powerful class of antioxidants may be potent Parkinson's treatment 2The largest research expedition of its kind near the site of Deepwater Horizon incident 2The largest research expedition of its kind near the site of Deepwater Horizon incident 3
(Date:11/27/2014)... Calcivis, a medical devices ... decay, today announces that it has completed a ... Imaging System. The Calcivis Caries Activity ... consumable combination designed to transform the assessment and ... a unique, proprietary bioluminescence approach combined with a ...
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 On January, ... the Baltimore and Washington D.C. science community to the ... The event, sponsored by the Protein Society, will take ... University Center, Room 312. Through discussion, presentations and ... structural importance of proteins, their role in the industry ...
(Date:11/26/2014)... CA (PRWEB) November 25, 2014 Silicon ... joins forces with RPM Alliance , provider of ... pharmaceutical companies. With the latest addition to its CRO ... free validated EDC system to India. , “We ... a robust and customizable EDC platform which is both ...
Breaking Biology Technology:Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2
... Mass., March 11 Boston Scientific,Corporation (NYSE: BSX ... Care Conference, which is being held March 18 - ... will make a 25-minute,presentation on Tuesday, March 18, beginning ... and Chief Financial Officer will,join Mr. LaViolette in a ...
... Advisory Board Programs Exemplify, Why Halogen ... Market, OTTAWA, March 11 /PRNewswire/ - Halogen ... and talent management software,announced today that its customers ... and challenges and play a critical role in ...
... TORONTO and MONTREAL, March 11 /PRNewswire/ - GreenField ... gasification and,catalysis technology company, have signed a Binding ... on a commercial scale., "We are excited ... a,commercial reality in Canada," said Bob Gallant, President ...
Cached Biology Technology:Halogen Customers Shape Industry-Leading Employee Performance and Talent Management Solution 2Halogen Customers Shape Industry-Leading Employee Performance and Talent Management Solution 3GreenField Ethanol and Enerkem Announce Plans to Make Cellulosic Ethanol a Commercial Reality 2GreenField Ethanol and Enerkem Announce Plans to Make Cellulosic Ethanol a Commercial Reality 3
...
Human PDGF R beta MAb (Clone # PR7212)...
Zebrafish Ephrin-B2 Biotinylated Affinity Purified PAb...
Collected from 8-12 week old New Zealand or Californian rabbits. Aseptically collected and processed to minimize hemolytic activity. Pricing: $60/unit for 1 - 10 units...
Biology Products: