Navigation Links
Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
Date:11/16/2010

Bioengineers from the University of California, San Diego have achieved the "Triple Crown" of stem cell culture they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation. Building better microenvironments for nurturing stem cells is critical for realizing the promises of stem-cell-based regenerative medicine, including cartilage for joint repair, cardiac cells for damaged hearts, and healthy skeletal myoblasts for muscular dystrophy patients. The advance could also lead to better model systems for fundamental stem cell research.

This work appears in a paper published online in Advanced Functional Materials on November 13.

While researchers have already created artificial environments for stem cells that provide chemical cues combined with either mechanical or electrical cues, the UC San Diego bioengineers say this is the first material reported in the scientific literature, to the best of their knowledge, that simultaneously provides all three cues to stem cells in a three dimensional supportive environment. Remarkably, the development of the new material was led entirely by bioengineering undergraduate students at UC San Diego.

In nature, stem cells communicate with other cells and with the extracellular matrix through chemical, electrical, and mechanical cues. "We mimicked all these cues that the native environment provides to the cells. This work is therefore fundamental to creating more life-like environments for stem cells in order to steer stem cells toward specific cell types such as chondrocytes, osteoblasts, myoblasts or cardiomyocytes," said Shyni Varghese, the bioengineering professor who advised the student researchers working in her Biomimetic Polymers and Stem Cell Engineering laboratory at the UC San Diego Jacobs School of Engineering.

Realistic in vitro microenvironments for stem
'/>"/>

Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. UC San Diego bioengineers fill holes in science of cellular self-organization
2. New method developed by UC San Diego bioengineers gives regenerative medicine a boost
3. Bioengineers succeed in producing plastic without the use of fossil fuels
4. Penn bioengineers create simulator to test blood platelets in virtual heart attacks
5. Entrust, 3M Collaborate to Provide End-to-End Secure ePassport Solution
6. Anabolic steroids provide a competitive edge in power lifting years after doping has ended
7. Paleozoic sediment curve provides new tool for tracking sea-floor sediment movements
8. Field Museum provides gold standard for mammal survey
9. Study provides insight on a common heart rhythm disorder
10. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
11. Brain structure provides key to unraveling function of bizarre dinosaur crests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
(Date:4/22/2014)... the University of Montana,s Wildlife Biology Program, co-wrote a research ... National Academy of Sciences on how streamwater chemistry varies ... Lowe and ... of Washington, the Cary Institute of Ecosystem Studies, the University ... examined 664 water samples collected every 10 meters along 32 ...
(Date:4/22/2014)... 2014) Biotechnology scientists must be aware of the ... licensing guidelines, according to a new paper from Rice ... the current issue of the journal Regenerative Medicine ... U.S. Supreme Court ruling in the case Association for ... genes are unpatentable. The court case and rulings garnered ...
(Date:4/22/2014)... expert will present a poster titled "A ... 7th International Nanotoxicology Congress to be held April ... Sharma will outline a strategy consistent with the 2007 ... Toxicity Testing in the 21st Century: A Vision and ... involving human cells and cell lines for mechanistic pathwaybased ...
Breaking Biology News(10 mins):New research focuses on streamwater chemistry, landscape variation 2New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... for Free-Electron Laser Science have devised a novel way to boil ... concept, which has not yet been demonstrated in practice, could heat ... Celsius in just half a picosecond (a trillionth of a second). ... one picosecond is to a second what one second is to ...
... like Alzheimer,s, Parkinson,s and Creutzfeldt-Jakob disease. But amyloid ... the development of new composite materials for the ... even make objects invisible. Researchers from Chalmers ... about amyloid in an article published in the ...
... Caribou in southern and eastern Canada may disappear from most ... takes the toll on their habitat that scientists predict in ... Nature Climate Change . Scientists looked at reservoirs of ... to stable habitats. They found that caribou populations in the ...
Cached Biology News:Ultrafast heating of water -- This pot boils faster than you can watch it 2Ultrafast heating of water -- This pot boils faster than you can watch it 3Alzheimer substance may be the nanomaterial of tomorrow 2Climate change threatens genetic diversity, future of world's caribou 2
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... antibody-drug conjugates for cancer, today announced the appointment of Thomas ... Reynolds has over 20 years, development experience gained in the ... Genetics. "I am delighted to welcome Tom at ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, 2014 ... Country Club, 1360 Almshouse Road, Warrington, Pa. , ... solely dedicated to finding a cure for hepatitis B and ... host its annual Crystal Ball on Friday, April 11 at ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
...  PharmAthene, Inc. (NYSE Amex: PIP ), a biodefense ... today that management will present at the ROTH 24th Annual ... 5:30 pm PT at the Ritz-Carlton Laguna Niguel in Dana ... , Monday, March 12, 2012 at 5:30 pm Place : ...
... Production of energy from the difference between salt water ... but now, using an ammonium bicarbonate salt solution, Penn ... with energy extracted from the salt-water fresh-water gradient to ... each having limitations, and putting them together," said Bruce ...
... SAN DIEGO, Mar.1, 2012 /PRNewswire-iReach/ -- FirstMark, ... meeting of its Scientific Advisory Board, that was held ... with distinguished backgrounds in cardiovascular medicine and research. The ... guidance for further clinical development and validation of FirstMark,s ...
Cached Biology Technology:Unique salt allows energy production to move inland 2Inaugural Meeting of the FirstMark Scientific Board of Advisors 2Inaugural Meeting of the FirstMark Scientific Board of Advisors 3
... from non-demolished blood that is ... The donors are not medicated ... maintained on an antibiotic free ... : 85 mg/ml (by Refractometry).Strain: ...
Alkaline Phosphatase (E. coli C75), 100 units. Removes 5'-phosphates from DNA. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Alkaline Phosphatases....
... cDNA Labeling Kit with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
... CyScribe GFX Purification Kit, 24 reactions. ... Cy3- and Cy5-labeled cDNA.Optimized reagents are ... and purification.Flexible and optimized protocols can ... with either Cy3- or Cy5-labeled nucleotides.Reliable ...
Biology Products: