Navigation Links
Bioengineered protein shows preliminary promise as new therapy for hemophilia
Date:10/23/2011

A genetically engineered clotting factor that controlled hemophilia in an animal study offers a novel potential treatment for human hemophilia and a broad range of other bleeding problems.

The researchers took the naturally occurring coagulation factor Xa (FXa), a protein active in blood clotting, and engineered it into a novel variant that safely controlled bleeding in mouse models of hemophilia. "Our designed variant alters the shape of FXa to make it safer and efficacious compared to the wild-type factor, but much longer-lasting in blood circulation," said study leader Rodney A. Camire, Ph.D., a hematology researcher at The Children's Hospital of Philadelphia.

"The shape of the variant FXa changes when it interacts with another clotting factor made available following an injury," added Camire. "This increases the functioning of the protein which helps stop bleeding." Camire is an associate professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania.

The study appears online today in Nature Biotechnology, and will be published in the journal's November 2011 print issue.

In hemophilia, an inherited single-gene mutation impairs a patient's ability to produce a blood-clotting protein, leading to spontaneous, sometimes life-threatening bleeding episodes. The two major forms of the disease, which occurs almost solely in males, are hemophilia A and hemophilia B, characterized by which specific clotting factor is deficient. Patients are treated with frequent infusions of clotting proteins, which are expensive and sometimes stimulate the body to produce antibodies that negate the benefits of treatment.

Roughly 20 to 30 percent of patients with hemophilia A and 5 percent of hemophilia B patients develop these inhibiting antibodies. For those patients, the conventional treatment, called "bypass therapy," is to use drugs such as factor VIIA and activated prothrombin complex concentrat
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bioengineered materials promote the growth of functional vasculature, new study shows
2. Photonic crystal biosensors detect protein-DNA interactions
3. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
4. Dont forget the vitamin A when working with its carrier protein
5. Saliva proteins could help detection of oral cancer
6. The structure of the Mre11 protein bound to DNA
7. New lab manual focuses on essential methods for purifying and characterizing proteins
8. Proteins in sperm unlock understanding of male infertility says new study
9. Response to immune protein determines pathology of multiple sclerosis
10. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
11. Human protein atlas will help pinpoint disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... 25, 2015  ABC Financial Services (ABC), the ... Health and Fitness Industry, today announced enhancements to ... The latest upgrade includes advances to the agreement ... check-in via Identity One fingerprint biometrics. The features ... interactive displays at the International Health, Racquet & ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris ... for the US, Canada , ... Asia-Pacific , Middle East , and ... are provided for the period 2013 through 2020. Also, a ... and analytics are derived from primary and secondary research. Company ...
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ... period 2013 through 2020. Also, a seven-year historic analysis is provided ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
... of getting from one place to another. Although many ... cues; things such as walls and corners to determine ... as rats and human children are so influenced by ... features such as a distinctive object or colored wall. ...
... with tendrils that extend far from the primary ... to an invariably poor prognosis. In a new ... journal PLoS Biology, Angela Johnston, Donna Senger, and ... mice with human gliomas and compared invasive cells ...
... Harvard University and the University of California, San Diego, ... genes determines the patterns of fur coloration that camouflage ... The work, published this week in the journal PLoS ... specific genetic changes have been linked to an organism,s ...
Cached Biology News:New study examines how rearing environment can alter navigation 2Interaction of just 2 genes governs coloration patterns in mice 2
(Date:3/2/2015)... March 02, 2015 Global ... formed alliance with Shenzhen HANK Bioengineering Co., Ltd. ... The alliance will establish a stem cells training ... China in September 2015. , Shenzhen HANK is ... an award-winning scientist, microbiologist and virologist, to integrate ...
(Date:3/2/2015)... Outside GC, the leading provider of on-demand, ... Debbie Casey as a member of the firm, further ... , Debbie has spent over 20 years in ... Care North America in both legal and business capacities. ... with Outside GC’s growing list of healthcare clients, with ...
(Date:3/1/2015)... (PRWEB) March 01, 2015 Market ... agreement for quality market research promotion on Internet. ... research reports worked out by DataGroup Booksellers. , ... Market Publishers Ltd, commented on the recent partnership ... DataGroup Booksellers in our team of publishers. Since ...
(Date:2/28/2015)... AZ (PRWEB) February 28, 2015 Increasing its ... World Films launches its first three episodes of The GMO ... Mile Project this month, as it continues its mission to ... launch, the project's first phase, to “uncover the truth about ... of media. , The GMO Truth Podcast is an expansion ...
Breaking Biology Technology:Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Outside GC Expands Healthcare Team 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3The Walk a Mile Project Launches “GMO Truth” Podcast 2
... 2011 ,   ... Matthew Roe as Chief Business Officer. Matthew joins,Crescendo ... Development & Licensing. During a 23-year ... management, acquisition, divestment, and sales,and marketing, and saw ...
... below 100 nanometres have numerous applications ranging from ... participates in a intragated FP7 European Project called ... nanoimprinting techniques (NIL), as a core aspect for ... followed are cost reduction, simpler fabrication process and ...
... classes of fundamental particles. Photons, the quanta of light, ... up atomic nuclei belong to the fermions. Bosons and ... level. This difference is expressed in their quantum statistics. ... was postulated, which was dubbed the anyon. In their ...
Cached Biology Technology:Crescendo Biologics Appoints Matthew Roe as Chief Business Officer 2Acrobatics for anyons: New test for elusive fundamental particle proposed 2
... Sampler Kit Kit Includes: Histone ... ul Histone Deacetylase 3 (HDAC3) Antibody, Catalog ... Antibody, Catalog #2072, 40 ul Histone Deacetylase ... Histone Deacetylase 6 (HDAC6) Antibody, Catalog #2162, ...
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
PlusOne EDTA, disodium salt, 100 g. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Buffers....
Biology Products: