Navigation Links
Bioengineer studying how to send drugs to lungs through nanotechnology
Date:1/23/2013

A UT Arlington bioengineering researcher has teamed with a UT Southwestern colleague to develop a nanoparticle drug delivery system that will help stimulate lung growth and function after partial lung removal or destructive lung disease.

Kytai Nguyen, an associate professor of bioengineering, is working on the drug-delivery portion of the project, which is funded through a $3.4 million National Institutes of Health grant through 2016. Nguyen's work will be underwritten by $440,000 of the larger grant.

"We will introduce drugs through inhaled nanoparticles that will stimulate lung growth and remodeling following partial lung removal," said Nguyen, who joined UT Arlington's College of Engineering in 2005 and holds a joint appointment with UT Southwestern Medical Center of Dallas.

"We will synthesize biocompatible, biodegradable polymers that will encapsulate, or load, and release the drugs where needed."

The polymer used to house the drugs will degrade with time, allowing the drugs to be released within the lung. Various polymers can be used to control this drug-release time. Magnetic or fluorescent labels may be incorporated into the nanoparticles as tracers initially, but omitted in final therapeutic formulations.

Connie Hsia, a professor of Internal Medicine at UT Southwestern will direct the overall project. She said that once the drugs are delivered via nanoparticles, the research team would be able to measure therapeutic response using non-invasive imaging, physiological testing, and detailed structural analysis.

"This research is important because currently there is no definitive cure for most destructive lung diseases except transplantation," Hsia said. "We have shown that partial lung removal may trigger regrowth of the remaining lung to compensate for the loss. Using nanoparticle as a vehicle for delivery of therapeutic compounds, we hope to amplify the lung's innate potential for regrowth."

Nguyen and Hsia hope their work will lead to better quality of life for people who have had a part of their lungs removed by surgery or destroyed by disease.

Nguyen has studied how physical and biological factors influence the proliferation of vascular smooth muscle cells, a condition that can lead to heart disease. She also has conducted research using focused laser beams called optical tweezers in nanoparticle-cell manipulation with Samarendara Mohanty, a UT Arlington associate physics professor.

Nguyen's work is representative of the research under way at The University of Texas at Arlington, a comprehensive undergraduate and graduate institution of nearly 33,000 students in the heart of North Texas. Visit www.uta.edu to learn more.


'/>"/>

Contact: Herb Booth
hbooth@uta.edu
817-272-7075
University of Texas at Arlington
Source:Eurekalert  

Related biology news :

1. Bioengineered marine algae expands environments where biofuels can be produced
2. Stanford bioengineer Christina Smolke wins NIH Directors Pioneer Award
3. Investigation of American Oriental Bioengineering, Inc. by Securities Lawyers at Goldfarb LLP Law Firm for Potential Shareholder Claim
4. U of M to lead international virtual institute studying climatic and human effects on Earth
5. Studying sex differences in autism focus of $15 million NIH award to Yale center
6. Genetic research develops tools for studying diseases, improving regenerative treatment
7. Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds
8. The role of stem cells in developing new drugs
9. Study suggests caution and further studies on drugs used to treat macular degeneration
10. Mosquito virus could lead to new vaccines and drugs
11. Getting (drugs) under your skin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bioengineer studying how to send drugs to lungs through nanotechnology
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies ... Technologies has installed a solar system on its roof top. “We will be ... of Sonic, Kenneth Raab stated. The company’s proud history of social responsibility and ...
(Date:7/14/2017)... ... 13, 2017 , ... LGC Maine Standards announces ... FDA 510 (k) clearance for use on Siemens Sysmex® CS-2500 System analyzers. The ... kit, prepared using the CLSI EP06-A “equal delta” sample preparation, offers five distinct ...
(Date:7/13/2017)... ... ... Thousands of pilots from across the country will visit the AMA’s International ... to Muncie to compete in various categories of model flying competition. Each pilot comes ... championships. , RC Pylon (July 14-21): One of the most fun competitions to watch! ...
(Date:7/13/2017)... ... 13, 2017 , ... In’Tech Medical SAS ( http://www.intech-medical.com ), ... completion of a major transaction with Eurazeo PME. The reputable French private equity ... fuels In’Tech Medical’s service offerings while leveraging the company’s manufacturing expertise and global ...
Breaking Biology Technology: