Navigation Links
Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
Date:8/20/2008

r oral drug delivery because they can survive the stomach conditions before they release their contents in the intestines," noted Murthy.

Murthy's group is also examining the use of polyketals to treat acute liver failure a condition when the liver stops functioning because macrophages in the liver create reactive oxygen species. One treatment is the delivery of superoxide dismutase, an enzyme that detoxifies superoxide. Incorporating the enzyme inside a polyketal poly(cyclohexane-1,4-diyl acetone dimethylene ketal) allows the enzyme to be released very quickly in an acidic environment.

"Patients with acute liver failure need drugs as soon as possible or else they'll die," said Murthy. "We've tailored the polyketal's hydrolysis rates to deliver the drug in one or two days."

Nick Crisp, professor of microbiology and immunology at the University of Rochester Medical Center, and Robert Pierce, currently head of anatomic pathology at Schering-Plough Biopharma Schering-Plough Biopharma and formerly of the University of Rochester Medical Center, are collaborating on this project. Georgia Tech, Emory and the University of Rochester have filed three patent applications on the polyketal drug delivery system.

To treat other illnesses, it may be necessary to deliver proteins to a diseased organ. In a presentation on August 18, Georgia Tech researchers described such a method, which was developed by Murthy, Michael Davis, an assistant professor in the Coulter Department of Biomedical Engineering, and graduate student Jay Sy.

"Delivering proteins inside microparticles has been limited because getting the protein into the microparticles required organic solvents that frequently destroyed the proteins," explained Murthy. "To overcome this problem, we developed a method of simply immobilizing the protein on the surface of the microparticles."

The researchers incorporated a nitrilotriacetic acid-lipid conjugate into the pol
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. MSUs discovery of plant protein holds promise for biofuel production
2. Nano vaccine for hepatitis B shows promise for third world
3. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
4. Genetic data promises new future for kiwi fruit
5. Telescope embedded in glasses lens promises to make driving easier for visually impaired
6. CMV infections affect more than just patients with compromised immune systems, researchers find
7. Cell-based therapy shows promise in patients with Parkinsons disease
8. Cancer immunotherapy shows long-term promise in lung cancer
9. Prototype terahertz imager promises biochem advances
10. 2 new therapies show promise for cancer patients
11. Challenges and promise of cell-based therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
(Date:7/10/2014)... cities in New Mexico, nearly every public golf course ... precious potable water supplies. Across the U.S. Southwest as ... receive treated effluent. Reusing the effluent increases the sustainability ... homeowners alike fertilize their lawns during the growing season. ... Mexico State University turfgrass expert has a new vision ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
(Date:7/10/2014)... , July 1, 2014 Smart ... way for convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), ... GOOG ), Apple Inc. (NASDAQ: AAPL ... Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric ... to announce that the second series of 30 second spots ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... with Secretary of the Interior Sally Jewell to discuss ... Interior, including the National Park Service, the U.S. Geological ... oversees offshore development of both renewable and conventional energy ... a petroleum engineer, discusses the role of science in ...
... often considered to be an activity reserved for adults, ... introduced that promote gardening,s "green" attributes. Physical benefits of ... for adults and seniors--now, a study from researchers in ... benefits of digging, raking, and weeding. Researchers Sin-Ae Park, ...
... space are offering scientists a clue as to how astronauts, immune ... of researchers from the University of California at Davis and the ... on fruit flies in space. The team,s findings are ... Fruit flies, innate immune system is similar to that of humans ...
Cached Biology News:Gardening provides high-to-moderate physical activity for children 2
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Robert Harman, ... Veterinary Medicine company, is proud to announce the relaunch of ... launching with a new series called “ What are Stem ... give an honest and straightforward foundation in the basics of ... educated decision on the right type of treatment when considering ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2
... 7 When leading contract research,organization Pharm-Olam International (POI, ... voice-over Internet protocol (VoIP),system that would better serve the ... catastrophic., POI initially selected a local vendor to ... immediately clear the solution was a bigger problem,than the ...
... LifeQuest World Corporation,(OTC Bulletin Board: LQWC) is pleased ... ImmunXT, their Immune System enhancement supplement, has,been released ... of March 2008.,ImmunXT has been proclaimed as "the ... (US Patent #7,205,284 B2),is a bio-active Micro-algae Complex ...
... Eastern Time -, SOUTH SAN FRANCISCO, Calif., May ... biopharmaceutical company focused,on oncology, today reported on its corporate ... 31, 2008., "During the first quarter, we made ... data to demonstrate the potential of,picoplatin as a new ...
Cached Biology Technology:Pharm-Olam Finds VoIP Solution in Taridium LLC 2LifeQuest World Launches Immune System Boosting Supplement to the North American Market 2Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 2Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 3Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 4Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 5Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 6Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 7Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 8Poniard Pharmaceuticals Reports First Quarter 2008 Financial Results and Corporate Update 9
... The Cetac Ultrasonic Nebulizers are available in two ... difference between these two models is that the ... to create a drier aerosol for improved detection ... detection limits for a range of elements by ...
...
... A-type ribonucleases Product Description: ,QIAGEN RNase Inhibitor ... binds noncovalently and inactivates a variety of ... It does not interfere with RNase T1, ... RNase Inhibitor inhibits greater than 90% of ...
...
Biology Products: