Navigation Links
Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
Date:8/20/2008

A family of biodegradable polymers called polyketals and their derivatives may improve treatment for such inflammatory illnesses as acute lung injury, acute liver failure and inflammatory bowel disease by delivering drugs, proteins and snips of ribonucleic acid to disease locations in the body.

"The polyketal microparticles we developed are simply a vehicle to get the drugs inside the body to the diseased area as quickly as possible," said Niren Murthy, assistant professor in the Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "The major advantage to using these polyketals to deliver drugs is that they degrade into biocompatible compounds that don't accumulate in a patient's tissue or cause additional inflammation."

Details about the polyketals and clinical applications were described during three presentations on August 18-20 at the 236th American Chemical Society National Meeting in Philadelphia. This research initially started in 2003 is funded by the National Science Foundation and the National Institutes of Health.

In a presentation on August 19, graduate student Scott Wilson detailed a new polyketal derivative aimed at enhancing the treatment of inflammatory bowel disease an illness that causes the large and small intestines to swell.

The new polymer has the advantage of stability in both acids and bases. It degrades only in the presence of reactive oxygen species, which are present in and around inflamed tissue. Cell culture experiments have demonstrated that the microparticles degraded more rapidly in cells that overproduced superoxide, a reactive oxygen species.

The researchers are currently collaborating with Didier Merlin, a professor in the Division of Digestive Diseases at Emory University, to investigate loading these polyketals with therapeutics to treat inflammatory bowel disease.

"We think these microparticles are going to be fantastic fo
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. MSUs discovery of plant protein holds promise for biofuel production
2. Nano vaccine for hepatitis B shows promise for third world
3. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
4. Genetic data promises new future for kiwi fruit
5. Telescope embedded in glasses lens promises to make driving easier for visually impaired
6. CMV infections affect more than just patients with compromised immune systems, researchers find
7. Cell-based therapy shows promise in patients with Parkinsons disease
8. Cancer immunotherapy shows long-term promise in lung cancer
9. Prototype terahertz imager promises biochem advances
10. 2 new therapies show promise for cancer patients
11. Challenges and promise of cell-based therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
(Date:3/12/2015)... , March 12, 2015 IriTech, a leading ... member of the Texas Instruments Design Network, announced today ... has demonstrated its IriShield USB MK2120U device during a ... for pension distribution. The iris scanner ... be marketed in India through ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... 11, 2015 Research and Markets ( ... "Access Control Market by Product, Application & By Geography ... to their offering. , This report predicts ... $10.4 billion by 2020, with an estimated CAGR of ... the products types such as contact cards & readers, ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... University of Adelaide study has identified the risk of ... reproductive technology. In the most comprehensive study of ... Robinson Institute have compared the risk of ... commonly available internationally, such as: IVF (in vitro fertilization), ...
... treatment and display heightened tumor-generating capacity can be identified by ... cells, a research team led by scientists at The University ... 3 edition of Cell Stem Cell . ... first time to separate low-PSA and high-PSA prostate cancer cells. ...
... a donated human retina to an Indiana University researcher ... helped uncover a previously undetected mechanism causing the disease. ... how millions of dollars are spent investigating the cause ... neovascularization. Working at IU,s Biocomplexity Institute, postdoctoral ...
Cached Biology News:Higher risk of birth defects from assisted reproduction 2Higher risk of birth defects from assisted reproduction 3Higher risk of birth defects from assisted reproduction 4Scientists identify prostate cancer stem cells among low-PSA cells 2Scientists identify prostate cancer stem cells among low-PSA cells 3Scientists identify prostate cancer stem cells among low-PSA cells 4Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 2Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 3Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 4
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... Agnition announced today that it will be featured ... the first time at 7:30 a.m. CST March 31 ... the extremely important role soil microbes perform in crop ... Catalyst™ technology that enhances soil and plant health for ... again on April 28. , A biochemist at Agnition ...
(Date:3/25/2015)... 25, 2015 The surging prevalence ... have fuelled social media growth, with over 50% ... in social networking. Insurance companies are making use ... clients and promote a diversity of their services ... increasingly exploiting social networking services as part of ...
(Date:3/25/2015)... ROCKVILLE, Md. , March 25, 2015 ... been named a finalist for "Best Contract Research Organization" ... by the World Vaccine Congress. This ... as a finalist for the award, winning for "Best ... receiving a "Highly Recommended" distinction in 2013. ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... 5, 2011 Cord Blood America, Inc . ( ... umbilical cord blood stem cell preservation company focused ... families nationwide and internationally, is pleased to announce that the ... lawsuit filed by Cryo-Cell International against Cord Blood America, which ...
... 3, 2011 -- Researchers at the Hebrew University of Jerusalem ... successfully altering nanocrystal properties with impurity atoms -- a process ... of improved semiconductor nanocrystals. Semiconductor nanocrystals consist of ... than the width of a human hair. These tiny particles ...
... Calif., April 4, 2011 Ambry Genetics announced today ... (CSP) in Ion Torrent,s new service provider program. Ion ... are trusting with their samples has been trained and ... sequence data. (Logo: http://photos.prnewswire.com/prnh/20110307/LA59848LOGO ) ...
Cached Biology Technology:Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition 2'Nanocrystal doping' developed by Hebrew University researchers enhances semiconductor nanocrystals 2Ambry Genetics is First Authorized Customer Service Provider in New Ion Torrent CSP Program 2Ambry Genetics is First Authorized Customer Service Provider in New Ion Torrent CSP Program 3
... The new MALDI O-TOF creates a new ... an orthogonal platform that has been licensed ... University of Manitoba. , As the first ... design and collisional cooling, the prOTOF 2000 ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
...
Biology Products: