Navigation Links
Bioclocks work by controlling chromosome coiling
Date:11/21/2007

d, it is open and uncoiled and, when it is supercoiled, it is twisted into a smaller, more condensed state. So, the researchers used a standard method, called gel electrophoresis, to measure the extent of a plasmids supercoiling during different points in the day/night cycle.

The researchers found a distinct day/night cycle: The plasmid is smaller and more tightly wound during periods of light than they are during periods of darkness. They also found that this rhythmic condensation disappears when the cyanobacteria are kept in constant darkness.

This is one of the first pieces of evidence that the biological clock exerts its effect on DNA structure through the coiling of the chromosome and that this, in turn, allows it to regulate all the genes in the organism, says Woelfle.

Some cyanobacteria use their biological clocks to control two basic processes. During the day, they use photosynthesis to turn sunlight into chemical energy. During the night, they remove nitrogen from the atmosphere and incorporate it into a chemical compound that they can use to make proteins.

According to the Johnson labs oscilloid model, the genes that are involved in photosynthesis should be located in regions of the chromosome that are turned on by the tighter coiling in the DNA during the day and turned off during the night when the DNA is more relaxed. By the same token, the genes that are involved in nitrogen fixation should be located in regions of the chromosome that are turned off during the day when the DNA is tightly coiled and turned on during the night when it is more relaxed.

The researchers see no reason why the bioclocks in higher organisms, including humans, do not operate in a similar fashion. This could be a universal theme that we are just starting to decipher, says Woelfle.

The DNA in higher organisms is much larger than that in cyanobacteria and it is linear, not circular. Stretched end-to-end, the genome in a mammalian cell is about six feet long
'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Controlling for size may also prevent cancer
2. UT Southwestern researchers identify hundreds of genes controlling female fertility
3. Hot spots the key to controlling European carp in Australia
4. Grant supports study of abnormal ring-shaped chromosomes
5. X-effect: female chromosome confirmed a prime driver of speciation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bioclocks work by controlling chromosome coiling
(Date:8/21/2014)... intake, health and quality of life of older adults ... the University of Waterloo receiving close to $1.5 million ... (CIHR). , Professor Heather Keller, of the Faculty ... research chair in nutrition and aging, will receive $979,000 ... in long-term care homes are poorly nourished. The project ...
(Date:8/21/2014)... Oct. 18-22, 2014 , WHERE: , San ... Diego, CA 92101 , WHAT: , Invited ... the latest research in human genetics. Examples of ... abstracts on rare genetic variants in health and ... for sun sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) ...
(Date:8/21/2014)... Researchers from North Carolina State University have developed a ... The model has applications for creating new materials as ... , "Our new technique allows us to model much ... so much more quickly," says Nan Li, lead author ... student in NC State,s Department of Materials Science and ...
Breaking Biology News(10 mins):Grants will fund landmark aging research at Waterloo 2American Society of Human Genetics 2014 Annual Meeting 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... and vegetables is a new, patented technology in which a ... "etch" information on produce, thereby eliminating the need for common ... a variety of fruits and vegetables and is being used ... been been approved in Asia, South Africa, Central and South ...
... of Illinois at Chicago have received $1 million from ... the relationship between "fat taxes" and food consumption, diet ... project was made available through the American Recovery and ... state tax rates associated with restaurants and with specific ...
... If a circadian rhythm is like an orchestra the united ... chemical may serve as the conductor, or at least as the ... ), the active ingredient in color safe bleach. Produced in all ... active and resting phases of living things, new research by USC ...
Cached Biology News:Laser etching safe alternative for labeling grapefruit 2UIC receives $1 million grant to study 'fat taxes,' diet, obesity 2Not just bleach: Hydrogen peroxide may tell time for living cells 2Not just bleach: Hydrogen peroxide may tell time for living cells 3
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... An international research team including DESY scientists has observed ... The team reports in the journal Science ... lattices inside the nanodroplets. It is the first time ... in larger samples of what is known as superfluid ... exceeded our best expectations," says Andrey Vilesov of the ...
(Date:8/21/2014)... , August 21, 2014 ... http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition of ...  report to their offering.       ... as hormone therapy, is a means of ... produced by the body. This type of ...
(Date:8/21/2014)... N.Y. , Aug. 21, 2014 ... launch of their Nutraceutical "TELO-20 for Dogs" with ... only Telomere-lengthening supplement in the world for dogs. ... of every chromosome in the body. A wealth ... leading experts in Telomere Science and Aging, including ...
Breaking Biology Technology:Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
... commentary with Michael J. Cronin, Ph.D., J.D., an intellectual property ... look at the facts in the dispute over three important ... the history behind similar disputes - shows a strong likelihood ... all of its patent rights, even if some of its ...
... writing a series of articles on raising capital from investors. This ... of the time when raising equity capital, the offering terms are ... . When dealing with angel investors , it is ... ,Sometimes prospective angel investors will want to negotiate the initial term ...
... who once said everyone will be famous for 15 minutes, couldn't ... might have on his prediction. , ,With these tools, everyone can ... even that. It seems that 15 minutes is about all anyone ... of Silicon Valley. , ,I was reminded of this after ...
Cached Biology Technology:WARF is likely to hold on to stem cell patent rights 2WARF is likely to hold on to stem cell patent rights 3WARF is likely to hold on to stem cell patent rights 4WARF is likely to hold on to stem cell patent rights 5WARF is likely to hold on to stem cell patent rights 6WARF is likely to hold on to stem cell patent rights 7WARF is likely to hold on to stem cell patent rights 8Capital-raising term sheets for angels and venture capitalists 2Capital-raising term sheets for angels and venture capitalists 3Capital-raising term sheets for angels and venture capitalists 4Capital-raising term sheets for angels and venture capitalists 5On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3
... the proven features of the pET, BacVector ... all of the benefits and versatility of ... The pTriEx vectors have been extensively tested ... all three expression systems. In each case, ...
... the first instrument engineered to match the ... by thousands of research centers worldwide. It ... which are ideally suited for high-speed temperature ... extremely high surface-area-to-volume ratio. ,By combining glass ...
... the cost-effective solution for entry level imaging ... research imaging tasks, MetaVue enables time lapse, ... analysis. Compatibility with MetaMorphs extensive and ... has the power to drive motorized microscopes, ...
... Clear amber to slightly cloudy ... 10 vials per set, each containing ... homogenized in the following proportions by ... A (mannide monooleate emulsifier), and 0.1% ...
Biology Products: