Navigation Links
Biochemists uphold law of physics
Date:7/15/2013

Experiments by biochemists at the University of California, Davis show for the first time that a law of physics, the ergodic theorem, can be demonstrated by a collection of individual protein molecules -- specifically, a protein that unwinds DNA. The work will be published online by the journal Nature on July 14.

Using technology invented at UC Davis for watching single enzymes at work, Bian Liu, a graduate student in the Biophysics Graduate Group and professor Steve Kowalczykowski, Department of Microbiology and Molecular Genetics and UC Davis Cancer Center, found that when they paused and restarted a single molecule of the DNA-unwinding enzyme RecBCD, it could restart at any speed achieved by the whole population of enzymes.

"It's pretty impressive," said Daniel Cox, a physics professor at UC Davis who was not involved in the work. "The laws of physics should apply to biological systems, and it turns out they do."

The results also have implications for understanding how proteins fold into their correct shape, for exploring interactions between drugs and their targets, and for engineering enzymes for new functions.

The ergodic theorem, proposed by mathematician George Birkhoff in 1931, holds that if you follow an individual particle over an infinite amount of time, it will go through all the states that are seen in an infinite population at an instant in time. It's a fundamental assumption in statistical mechanics -- but difficult to prove in an experiment.

Liu and Kowalczykowski weren't attempting to test laws of physics when they began the work. They wanted to know why RecBCD, an enzyme that unwinds DNA in E. coli bacteria, showed so much variability in its rate of action.

RecBCD attaches to and moves along DNA, unwinding the double helix into two separate strands. It has two jobs in the cell: to allow damaged DNA to be repaired, and to break down invading "foreign" DNA from viruses.


'/>"/>
Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
2. Wayne State welcomes undergraduates from around the US for physics research experience
3. Discovery of new material state counterintuitive to laws of physics
4. Frontiers launches new open-access journal in physics
5. UT Arlington physics team demonstrates new power generation technique
6. New book on physics principles by Wayne State professor explains life as we know it
7. How a fish broke a law of physics
8. Physics and math shed new light on biology by mapping the landscape of evolution
9. Physics confirms sprinters are performing better than ever before
10. The physics of going viral
11. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... tiny strands of nucleic acid that contain instructions for ... data, our DNA is copied into RNA molecules, which ... in our cells. , Several years ago, scientists ... other known RNAs, this molecule is circular, and was ... has been known about how they are produced. Moreover, ...
(Date:9/18/2014)... and ethnic groups describe losing eyesight as potentially ... more so than other conditions including: loss of ... 49% of non-Hispanic whites, 43% of Asians and ... ailment is the worst that could happen to ... AIDS/HIV. Hispanics and Asians ranked cancer first ...
(Date:9/18/2014)... devastated algal forests in the eastern Mediterranean Sea pose ... their distribution continues to expand as the climate warms, ... team of researchers led by Dr Adriana Vergs of ... Institute for Advanced Studies in Spain, is published in ... team surveyed more than 1000 kilometres of coastline in ...
Breaking Biology News(10 mins):Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3Tropical fish a threat to Mediterranean Sea ecosystems 2
... in protecting us from diseases, but how does it ... that before dendritic cells move to the lymph nodes ... move much faster. Immature dendritic cells patrol the tissues ... they undergo a rigorous maturation process. During this maturation ...
... A stunning discovery based on epigenetics (the inheritance of ... nutrient found in eggs and other foodsduring pregnancy may ... This finding by a team of biologists at Boston ... pregnancy to breast cancer. It also is the first ...
... who have had the common chest wall deformity known ... ability to exercise, according to a study published December ... conducted at 11 North American hospitals, involved telephone interviews ... 8 and 21 who had pectus excavatum surgery. ...
Cached Biology News:Immune cells reveal fancy footwork 2Eating eggs when pregnant affects breast cancer in offspring 2Marked improvement in body image, physical stamina, post-surgical pectus patients report 2Marked improvement in body image, physical stamina, post-surgical pectus patients report 3
(Date:9/18/2014)... KEEGO HARBOR, Mich. , Sept. 18, 2014  Health ... -based biotech firm investigating early-stage algae bioactive compounds and metabolic ... member to the company,s board of directors. Ms. Nola ... executive and investment advisor joined the board effective September 17, ... have Ms. Masterson agree to join our board," states ...
(Date:9/18/2014)... 18, 2014 Texas Governor Rick ... Texas A&M Health Science Center CEO Brett Giroir, ... Health and Human Services (HHS), State of Texas ... pandemic influenza vaccine manufacturing facility in Bryan, Texas, ... for the Texas A&M Biocorridor – a rapidly ...
(Date:9/18/2014)... Sept. 18, 2014 Research and Markets ... and Chinese Stem Cell Industry Report, 2014-2017" report ... undifferentiated biological cells that can differentiate into specialized cells ... cells. Stem cell therapy can be applied to treatment ... disease), nervous system diseases, damage or lesion of liver, ...
(Date:9/18/2014)... Research and Markets has announced the addition ... report to their offering. The ... and in-depth study on the current state of the ... a basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including development ...
Breaking Biology Technology:Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... Sheboygan, Wis. - Gov. Jim Doyle ... the Wisconsin Aerospace Authority - both of whom expressed ... for future space travel. , ,Mark Hanna, a city ... program, will join several already-named nominees for the commission, ...
... will have the exclusive global distribution rights to a stem ... with its developer, ThermoGenesis . , ,Under the terms ... product, known as the Auto Express System, to the ... of private umbilical cord blood banks. The AXP System extracts ...
... took another turn last month when the District Court of ... Cigar, Inc ., v. GoTo.com, Inc . , ,Plaintiff ... of Yahoo! , ,GoTo sold several keywords, ... various JR Cigar competitors. , ,As mentioned in my prior ...
Cached Biology Technology:Wisconsin spaceport committee moves closer to formation 2Are consumers confused by search engine ads? 2Are consumers confused by search engine ads? 3Are consumers confused by search engine ads? 4
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
a1-Antitrypsin (human, alpha-1 AT)...
... demands of the routine trace metal analytical ... robust and simple to use instrumentation. The ... most challenging sample matrices found in the ... the toughest analytical challenges found in the ...
Biology Products: