Navigation Links
Biochemists find incomplete protein digestion is a useful thing for some bacteria
Date:10/31/2013

it, generating stable shorter fragments both in vitro and in vivo.

Further, they found that both long and short forms were essential for normal growth and that the short form was particularly important for DNA damage tolerance, suggesting that these fragments are not accidental but are made in a programmed manner.

Vass and Chien's new work shows that in some bacteria, short forms of DnaX are made instead by another method, proteolysis, with dramatic consequences for the cell, the biochemist says. "This type of convergent evolution results in similar protein outcomes, that is the generation of two forms through radically different mechanisms. This suggests that both long and short forms are crucial for all bacteria," he adds.

Protein degradation by energy-dependent proteases normally results in the complete destruction of target proteins, Chien notes. However, under particularly harsh artificial conditions in the test tube, these proteases can stall on certain targets. But until the recent UMass Amherst experiments, such an effect had never been seen inside a living bacterial cell, he adds.

Chien feels this mode of partial digestion could be useful in other bacteria to generate new functions from existing proteins and increasing the ability of a single gene to encode for multiple protein functions. This work was supported by NIH's National Institute for General Medical Sciences and by UMass Amherst.


'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
2. Biochemists uphold law of physics
3. IU biologists offer clearer picture of how protein machine systems tweak gene expression
4. Making memories: How 1 protein does it
5. Embryonic development protein active in cancer growth
6. More effective method of imaging proteins
7. The loss of a protein makes jump the tumor to the lymph node
8. Gold nanoantennas detect proteins
9. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
10. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
11. Protein jailbreak helps breast cancer cells live
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biochemists find incomplete protein digestion is a useful thing for some bacteria
(Date:6/24/2015)... Switzerland , June 24, 2015 ... partnership with emerging biometric password solution one face ... one face in, entering ... a ground-breaking and affordable multifactor-authentication biometric answer to ... recognition technology, provided in partnership with KeyLemon, one ...
(Date:6/23/2015)... Fla. , June 23, 2015 /PRNewswire/ ... management and authentication solutions, today announced enhanced functionality ... multi-factor authentication solution.  The enhancements build on ... of the DigitalPersona Altus platform and provide ... compatibility. In today,s environment of ...
(Date:6/17/2015)... and HILDEN, Germany , June 17, 2015 ... Frankfurt Prime Standard: QIA) today launched new Investigator ® ... laboratories in the United States . The ... analyze multiple key genomic markers (short tandem repeats or STRs) ... Sensor to evaluate the quality of DNA in each sample, ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... The Van Andel Research Institute (VARI) and the ... alliance that will enable both to maximize their worldwide ... institutes jointly announced today the initiation of an "alliance ... Rapids, Mich.-based VARI and Phoenix, Ariz.-based TGen will enable ...
... to identify microbes that may cause preterm labor in some ... contractions and an early birth, and look at different groups ... prematurity. The work of seven researchers will be supported ... Prematurity Research Initiative (PRI) grants. The nearly $2.7 million ...
... against respiratory infections, the body typically produces a little fluid ... research suggests that the influenza virus can tip the balance ... supply of oxygen to the rest of the body. ... but this research suggests that it,s not the presence of ...
Cached Biology News:Van Andel Research Institute and TGen undertake alliance to promote science and health 2Van Andel Research Institute and TGen undertake alliance to promote science and health 3March of Dimes provides $2.7 million in new funding for preterm birth research 2March of Dimes provides $2.7 million in new funding for preterm birth research 3Study: Fluid buildup in lungs is part of the damage done by the flu 2Study: Fluid buildup in lungs is part of the damage done by the flu 3
(Date:6/29/2015)... , June 29, 2015   For the seventh ... sciences to assess their overall digital maturity called the ... that these companies are not maturing fast enough. While ... industry in numerous ways overall and customers are increasingly ... terms of digital customer engagement.  ...
(Date:6/26/2015)... , June 26, 2015   Aratana ... a pet therapeutics company focused on the ... products for companion animals, today announced positive ... of capromorelin (AT-002), the company,s innovative therapeutic ... a small molecule that mimics ghrelin, the ...
(Date:6/26/2015)... , June 26, 2015  A San Francisco ... products made with synthetic rhino horn: beer in ... Vietnam . In response to the emerging ... manufacture, marketing and sale of synthetic rhino horn.  ... and Save the Rhino International (SRI) released ...
(Date:6/26/2015)... , June 23, 2015 ... announced the addition of the "Global Cancer ... offering. Market introduction of cancer biosimilar ... and commercialization potential. Chemotherapeutic drugs have dominated the ... modalities have been introduced in past few years. ...
Breaking Biology Technology:Results from Digital Maturity Study Show Pharma Lagging 2Results from Digital Maturity Study Show Pharma Lagging 3Results from Digital Maturity Study Show Pharma Lagging 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 2Aratana Therapeutics Announces Positive Pivotal Results for AT-002 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 5Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3
... Application of the RoboCycler Gradient 96 temperature ... , Stratagenes RoboCycler Gradient 96 temperature cycler ... perform fluorescent-tag cycle,sequencing using the ABI PRISM ... Hot Top Assembly eliminates the need for oil or ...
... Allelic discrimination kits with excellent specificity, sensitivity, and,assay ... Lingyu Chen ,Stratagene , Because of their unique ... differences, making them ideal for mutation detection and,allelic ... developed a,series of Mx4000 molecular beacon allelic discrimination ...
... , Douglas Drake Michelle Cayouette Lisa Filippone ,Bob LeSchofs ,Stratagene , , ... , , Figure 1: The ... Stratagene has developed the new SmartPower , ... electrophoretic application. The SmartPower 4000 power supply has been, ...
Cached Biology Technology:Automated Fluorescent-Tag Cycle Sequencing 2Automated Fluorescent-Tag Cycle Sequencing 3Automated Fluorescent-Tag Cycle Sequencing 4Automated Fluorescent-Tag Cycle Sequencing 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 2Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 3Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 4Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 6Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 7A Versatile Power Supply for All Electrophoresis Applications 2A Versatile Power Supply for All Electrophoresis Applications 3A Versatile Power Supply for All Electrophoresis Applications 4A Versatile Power Supply for All Electrophoresis Applications 5
... Amplification Kit, 100 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
For quantitative determination of Aldolase in Serum (an indicator of muscle damage). Ready-to-use liquid stable reagent. Formulated to eliminate interference from pyruvates. Application sheets are ...
This Universal 24" X 18" (61 X 45.7cm.) shaker platforms will accept any Thermo Forma shaker flask clip....
Biology Products: