Navigation Links
Bioactive peptides found to promote wound healing

BOSTON (December 7, 2010) Newly-created bioactive peptides promote wound healing through the growth of new blood vessels and epithelial tissue, such as skin. These wound-healing peptides, synthesized by researchers at the Tufts Center for Innovations in Wound Healing Research, increased angiogenesis in vitro by 200 percent. The discovery, reported online in advance of print this week in Wound Repair and Regeneration, provides a better understanding of the mechanisms regulating wound healing and may lead to new therapies for acute and chronic wound healing.

"We identified specific bioactive peptides that are produced from collagenase treatment of extracellular matrix, which stimulate the healing process within a wound. By creating combinations of several key peptide fragments, we were able to synthesize an entirely novel class of wound-healing peptides that promote the fundamental response to injury: blood vessel formation and epithelialization," said senior author Ira Herman, PhD, a professor of molecular physiology and pharmacology at TUSM; member of the cell, molecular & developmental biology, and cellular & molecular physiology program faculties at the Sackler School of Graduate Biomedical Sciences; and director, Tufts Center for Innovations in Wound Healing Research.

"This is the first time these peptides have been identified and synthesized and we hope that these discoveries and new technologies will have broad implications for acute, chronic, burn, and scarless wound healing," Herman continued.

The team from Tufts used a three-dimensional wound model to examine the effect of the bioactive peptides on wound healing. After three days, wounds treated with the peptides showed signs of robust repair, while controls did not.

"We found that collagenase enzyme derived from Clostridium histolyticum bacteria releases biologically active fragments peptides from extracellular mammalian proteins. These peptides stimulate proliferation of capillary endothelial cells, enhance microvascular remodeling in the 2-D model, and induce endothelial sprouting in a 3-D model of injury repair, and therefore are likely to have potential to stimulate blood vessel formation and promote healing in response to injury in animals and humans," said first author Tatiana Demidova-Rice, BS, a PhD candidate in the cell, molecular and developmental biology program at the Sackler School of Graduate Biomedical Sciences at Tufts.

Angiogenesis, the formation of new blood vessels from existing vessels, is a key step in all types of wound healing from knee scrapes to venous stasis ulcers, pressure sores and diabetic foot ulcers. In order for tissues to be repaired, there must be an adequate blood supply bringing nutrients, oxygen, and signaling molecules to the site of the injury. Collageneses are enzymes that remodel extracellular matrix by cleaving one of its key components, collagen.

"The most potent wound-healing peptide is a 'combinatorial' peptide synthesized from bioactive fragments derived from the collagenase treatment of biosynthesized matrix. Outcomes of these studies suggest that it could be possible to create personalized regenerative medicine-based wound healing therapies and platforms that would be tailored to individuals. We are currently testing the efficacy of these fragments in an effort to develop better treatments for wound healing. Formulation of the bioactive peptides into heat-stable and portable materials could be of extreme value to soldiers injured in combat," said Herman.

As director of the Tufts Center for Innovations in Wound Healing Research (TIWR), Herman brings together investigators from a broad range of disciplines to advance wound healing research and therapeutics. Researchers combine recent insights and advances in wound-healing biology, materials sciences, and bioengineering to create fully-vascularized organ constructs for personalized regenerative medicine, while offering new and innovative opportunities for drug screening, discovery and development. TIWR investigators are currently developing cutting-edge technologies in biomaterials sciences and nano-fabrication processing to create personalized wound healing therapeutics, including "next generation" wound care products for civilian and soldier use.


Contact: Siobhan Gallagher
Tufts University, Health Sciences

Related biology news :

1. Scientists watch as peptides control crystal growth with switches, throttles and brakes
2. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
3. Buyer beware: Dangerous levels of lead found in used consumer products
4. MU plant genome research receives $3 million boost from National Science Foundation
5. Reading the signs: Plants and animals found common ground in response to microbial threats
6. Gene links to anorexia found by Childrens Hospital of Philadelphia researchers
7. Gates Foundation continues funding of tuberculosis research at Weill Cornell
8. Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
9. Undergraduates low-cost ultrasound system wins Gates Foundation grant
10. Viertel Foundation Fellowship for leading cancer researcher
11. Paradise lost -- and found
Post Your Comments:
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:6/1/2016)... YORK , June 1, 2016 ... Technology in Election Administration and Criminal Identification to Boost ... to a recently released TechSci Research report, " Global ... By Region, Competition Forecast and Opportunities, 2011 - 2021", ... 24.8 billion by 2021, on account of growing security ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Global demand for enzymes is forecast ... to $7.2 billion.  This market includes enzymes used ... biofuel production, animal feed, and other markets) and ... Food and beverages will remain the largest market ... of products containing enzymes in developing regions.  These ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight ... solutions to the healthcare market. The company's primary focus is on new product ... marketing strategies that are necessary to help companies efficiently bring their products to ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
Breaking Biology Technology: