Navigation Links
Bio-optics breakthroughs: Highlights of medical and bioscience research at Frontiers in Optics 2009
Date:9/29/2009

s is the folding and unfolding of protein molecules. But getting hold of single protein molecules is difficult, and monitoring their gymnastic gyrations is even more so. Scientists at Harvard University have produced new video-based "optical tweezers" techniques for doing just this, enabling ultra-precise measurements to be made in a way that is simple and effective. The current U.S. secretary of energy, Steven Chu, won a Nobel Prize for his contribution toward controlling atoms with laser beams inside an enclosed trap; he later pioneered the use of laser beams for actually holding tiny objects -- even biological molecules -- in place. The Harvard device is among the latest and most versatile use of this optical tweezers approach.

Wesley Wong of the Rowland Institute at Harvard and his colleagues have developed a unique optical tweezers system that uses a combination of interference imaging, light modulation and custom software algorithms to achieve the necessary resolution and stability to watch proteins fold. This system, which employs already-existing optical technology components, utilizes 3-D video tracking to measure the lengths of short molecular tethers with angstrom resolution (less than 1 billionth of a meter) and active feedback control for a force stability of femtoNewtons (10^-15 Newtons). Fluctuations can be glimpsed at rates faster than 100,000 frames per second -- all with inexpensive video-imaging. The act of protein folding is quantified by measuring the end-to-end distance of a single molecule while the strength of the tweezers' grip is varied.

The Wong group uses optical tweezers to study the behavior of single molecules under force in order to reveal the nanoscopic workings of biological systems. Together with their collaborators, they have used this approach to expose the molecular feedback mechanism behind the regulation of blood clotting and to determine the dynamic mechanical properties of spectrin, a structural molecule la
'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology news :

1. September Geology and GSA Today media highlights
2. Highlights from the September 2007 Journal of the American Dietetic Association
3. AGU journal highlights -- Sept. 6, 2007
4. IDEMA Reveals Program Highlights for DISKCON USA 2007
5. IDEMA Reveals Program Highlights for DISKCON USA 2007
6. October Geology and GSA Today media highlights
7. Media highlights in the November issues of Biophysical Journal
8. Highlights from the November 2007 Journal of the American Dietetic Association
9. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
10. November GEOLOGY and GSA TODAY Media Highlights
11. December GEOLOGY and GSA TODAY media highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... N.J. , Aug. 18, 2015 /PRNewswire/ ... a key contributor to the Submission Content ... by IRISS, a non-profit forum. Dedicated to the ... provides a neutral platform for industry, vendors, ... share information and work towards a standard ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
(Date:8/12/2015)... , August 12, 2015 ... of mobile payment innovation and advanced biometrics technology is ... the way consumers rely on using their credit cards, ... reinventing the future for payment services led by companies ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ), ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... how diseases are diagnosednew research published in the May 2010 ... ) details a noninvasive ground-breaking tool that detects signs of ... using traditional methods. Even better, this tool promises to detect ... before any permanent damage can occur. Its use may well ...
... crawls onto your lips while you sleep, drawn by the ... your blood. And if that,s not insult enough, it promptly ... Now Jean-Paul Paluzzi, a PhD candidate in biology ... to prevent the insects from leaving their messy calling card ...
... A small piece of RNA appears to play a ... according to lung disease researchers at the University of Pittsburgh ... examine microRNAs in the disease, is available online in the ... MicroRNAs are short strands of genetic material that ...
Cached Biology News:New tool helps scientists 'see' molecular signals of eye disease before symptoms arise 2The kiss of death: Research targets lethal disease spread by insect that bites lips 2Pitt researchers discover big role for microRNA in lethal lung fibrosis 2
(Date:8/28/2015)... ... August 28, 2015 , ... Riordan-McKenna ... McKenna, DO, announced today that the use of sterile, dehydrated amniotic tissue AlphaPATCHâ„¢ ... of an otherwise non-healing surgical knee wound. , The case involved a 78-year-old ...
(Date:8/27/2015)... 27, 2015  Neogen Corporation (NASDAQ: NEOG ) ... United Kingdom -based Lab M Holdings, ... and diagnostic systems. Lab M was ... provider of microbial testing and diagnostic products for the ... company currently sells into more than 70 countries worldwide, ...
(Date:8/27/2015)... ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: ... three and six-month periods ended June 30, 2015. Biorem,s complete second ... www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ... , 2014 , 2015 , 2014 ... 9,398 , 4,433 Gross profit , 1,656 ...
(Date:8/27/2015)... ... August 27, 2015 , ... ... needs and expertly narrows down the product choices to a manageable shortlist of ... down the list to models that fit best with the customer’s industry and ...
Breaking Biology Technology:Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Neogen acquires U.K.-based Lab M Holdings 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3METTLER TOLEDO Updates Online Scale Selection Tool 2
... Ardea Biosciences,Inc. (Nasdaq: RDEA ) today announced ... non-nucleoside reverse transcriptase inhibitors (NNRTIs),at the 21st International ... of the Company,s mitogen-activated ERK kinase,(MEK) inhibitors, RDEA119 ... for Cancer Research (AACR) annual meeting., ...
... Calif., April 7, 2008 InterWest Partners,announced ... to the venture capital firm,s Advisory Committee: ... Leroy Hood, and,former FDA commissioner Dr. Mark ... experienced professional advisors, providing strategic guidance,to the ...
... CPHD ) will announce financial results for ... Thursday, May 1, 2008. The announcement will be,followed ... afternoon at 4:30 p.m.,Eastern Time., John Bishop, ... Financial Officer and Michael Myhre, Vice President,Corporate Controller, ...
Cached Biology Technology:Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences 2Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences 3Prestigious Scientific Leaders Join InterWest Advisory Committee 2Prestigious Scientific Leaders Join InterWest Advisory Committee 3Prestigious Scientific Leaders Join InterWest Advisory Committee 4Cepheid Schedules Teleconference and Webcast for First Quarter 2008 Results 2
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... Product Goat polyclonal to Cholesterol Oxidase ... Reactivity / Specificity Cross-reacts with bacteria. ... Background Information Cholesterol oxidases exist as ... and are implicated in bacterial pathogenesis. In ...
Rabbit polyclonal to SERHL ( Abpromise for all tested applications). entrezGeneID: 94009 SwissProtID: Q9H4I8...
... anti-phospho-PTEN (Ser385) ... amino acid region encompassing the ... (Ser385), Accession ... Quality Assurance: Routinely ...
Biology Products: