Navigation Links
Bio-optics breakthroughs: Highlights of medical and bioscience research at Frontiers in Optics 2009
Date:9/29/2009

s is the folding and unfolding of protein molecules. But getting hold of single protein molecules is difficult, and monitoring their gymnastic gyrations is even more so. Scientists at Harvard University have produced new video-based "optical tweezers" techniques for doing just this, enabling ultra-precise measurements to be made in a way that is simple and effective. The current U.S. secretary of energy, Steven Chu, won a Nobel Prize for his contribution toward controlling atoms with laser beams inside an enclosed trap; he later pioneered the use of laser beams for actually holding tiny objects -- even biological molecules -- in place. The Harvard device is among the latest and most versatile use of this optical tweezers approach.

Wesley Wong of the Rowland Institute at Harvard and his colleagues have developed a unique optical tweezers system that uses a combination of interference imaging, light modulation and custom software algorithms to achieve the necessary resolution and stability to watch proteins fold. This system, which employs already-existing optical technology components, utilizes 3-D video tracking to measure the lengths of short molecular tethers with angstrom resolution (less than 1 billionth of a meter) and active feedback control for a force stability of femtoNewtons (10^-15 Newtons). Fluctuations can be glimpsed at rates faster than 100,000 frames per second -- all with inexpensive video-imaging. The act of protein folding is quantified by measuring the end-to-end distance of a single molecule while the strength of the tweezers' grip is varied.

The Wong group uses optical tweezers to study the behavior of single molecules under force in order to reveal the nanoscopic workings of biological systems. Together with their collaborators, they have used this approach to expose the molecular feedback mechanism behind the regulation of blood clotting and to determine the dynamic mechanical properties of spectrin, a structural molecule la
'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology news :

1. September Geology and GSA Today media highlights
2. Highlights from the September 2007 Journal of the American Dietetic Association
3. AGU journal highlights -- Sept. 6, 2007
4. IDEMA Reveals Program Highlights for DISKCON USA 2007
5. IDEMA Reveals Program Highlights for DISKCON USA 2007
6. October Geology and GSA Today media highlights
7. Media highlights in the November issues of Biophysical Journal
8. Highlights from the November 2007 Journal of the American Dietetic Association
9. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
10. November GEOLOGY and GSA TODAY Media Highlights
11. December GEOLOGY and GSA TODAY media highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
(Date:3/24/2015)... March 24, 2015   NexID Biometrics LLC, ... security-authentication needs, today announced the beginning of shipments of ... The company, based in Potsdam, ... three-day Connect:ID Expo, which began here today at the ... version 2.0 of its SDK boosts the accuracy rate ...
(Date:3/23/2015)... 2015   HOYOS Labs , a leading global ... that the Company will demonstrate multiple biometrics-based technologies under ... at Connect:ID on March 23 through 25, 2015, in ... highlight the IEEE Biometric Open Protocol Standard; free biometrics-based ... access control system. BOPS was invented by HOYOS Labs ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... genes are especially challenging because they combine many ... of non-coding elements (introns). During processing, introns are ... a template for proteins called messenger RNA (mRNA). ... of a functional protein or, worse, produce an ...
... Institute of Dental and Craniofacial Research (NIDCR), part of ... new piece to the puzzle of how tumor cells ... abnormal growth, a well-known process called angiogenesis. , As ... Cell, the scientists found that in addition to the ...
... cancer that is based on infection with a specially designed ... has shown promise in clinical trials. Now, new research suggests ... as well. The study, published in the July issue of ... to viral therapy after they have been incubated at an ...
Cached Biology News:Carnegie Mellon University research reveals how cells process large genes 2Carnegie Mellon University research reveals how cells process large genes 3New lead reported in tumor angiogenesis 2New lead reported in tumor angiogenesis 3Elevated temperature enhances success of viral cancer therapy 2
(Date:4/16/2015)... 16, 2015 Proove Biosciences , ... of BIO Contest for the 2015 BIO International ... 2015 BIO International Convention will take place June 15-18 ... the Buzz of BIO contest, industry leaders will be ... at the conference. The community voting period began on ...
(Date:4/16/2015)... April 16, 2015 The Council ... the prestigious 2015 Borlaug CAST Communication Award goes ... at Tuskegee University in Alabama. Award nominees must ... public presentations; and/or the use of television, radio, ... three areas. As a specialist in the field ...
(Date:4/16/2015)... ChemRar High Tech ... R&D group, and Lancet, Russian Distribution Company, ... commercialization of new medicines in ... stimulate the innovative development of the Russian ... ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , Through ...
(Date:4/16/2015)... , April 16, 2015  EMD Serono today ... Darmstadt, Germany , appointed ... Head of Global Clinical Development.  Dr. Reicin brings ... experience in Oncology and Immunology. She is an ... served as a Vice President in various capacities ...
Breaking Biology Technology:Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3
... 20, 2010) -- Recently, academic debate has been swirling ... the most ubiquitous of phenomena, including photosynthesis, the process ... particular, physicists have suggested that entanglement (the quantum interconnection ... atoms that are separated in physical space) could be ...
... ,, CHANTILLY, Va. , Aug. 6 ... as director of Chemical-Biological Defense Programs.  In this role, Chotani will lead ... U.S. Army and the Office of the Secretary of Defense, as well ... Health and the Centers for Disease Control. , ...
... Thursday, August 5, 2010 at 4:30 p.m. Eastern Time , ... BOTHELL, WA and VANCOUVER , Aug. 5 /PRNewswire-FirstCall/ - ... unaudited financial results for the three and six months ended June 30, 2010 and ... , , ...
Cached Biology Technology:TASC, Inc. Appoints Rashid Chotani to Lead Chemical-Biological Defense Programs 2TASC, Inc. Appoints Rashid Chotani to Lead Chemical-Biological Defense Programs 3OncoGenex Reports Second Quarter Financial Results 2OncoGenex Reports Second Quarter Financial Results 3OncoGenex Reports Second Quarter Financial Results 4OncoGenex Reports Second Quarter Financial Results 5OncoGenex Reports Second Quarter Financial Results 6OncoGenex Reports Second Quarter Financial Results 7OncoGenex Reports Second Quarter Financial Results 8OncoGenex Reports Second Quarter Financial Results 9
...
Anti-ZFP-38/RU49 Family: Zinc Finger Peptide Sequence: SVKVEDKDFPSTCSKK...
...
... total protein western blot (WtPAN) ... tissue specific protein expression in ... protein is included in each ... for comparison between different western ...
Biology Products: