Navigation Links
Bio-optics breakthroughs: Highlights of medical and bioscience research at Frontiers in Optics 2009
Date:9/29/2009

one critical aspect of peripheral nerve function -- the transport of essential proteins and other materials from one end of a nerve fiber to another.

Because they can snake several feet from the spinal cord to the extremities, peripheral nerves are often quite long -- sometimes 100,000 times longer than other cells in the body. The transportation of materials along this entire length is an extremely long and complicated process that can take days or even weeks. Studying this process has always been a complicated proposition, but Bianxiao Cui and her Stanford colleagues have demonstrated a new way of observing this transport by tagging single molecules, called nerve growth factors, with "quantum dots" that can be followed with a powerful microscope as they move along live neurons.

The researchers' technique is analogous to looking at a dark highway from the window of an airplane. The dark, invisible lanes of roads are microtubules, the skeleton of the cell. The nerve growth factor molecules ride in the cars that are illuminated by their quantum dot headlights. One thing Cui and her colleagues have observed, which has never been seen before, is that packages in transport can jump from one microtubule to another as they move along -- like cars switching lanes as they roll down the highway. They also discovered that the majority of those cars are single passenger; they only contain a single nerve growth factor molecule.

Scientists have known for a long time that these proteins are essential, since they help the nerve cells survive by regulating gene expression. But Cui and her colleagues showed that even a single molecule of nerve growth factor is enough to trigger the transport process and sustain signaling during axonal transport to the cell body. (Paper LSThB3, "Single Molecule Imaging of Axonal Transport in Live Neurons" is at 9 a.m. Thursday, Oct. 15).

WATCHING PROTEINS FOLD

One of the most important biological action
'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology news :

1. September Geology and GSA Today media highlights
2. Highlights from the September 2007 Journal of the American Dietetic Association
3. AGU journal highlights -- Sept. 6, 2007
4. IDEMA Reveals Program Highlights for DISKCON USA 2007
5. IDEMA Reveals Program Highlights for DISKCON USA 2007
6. October Geology and GSA Today media highlights
7. Media highlights in the November issues of Biophysical Journal
8. Highlights from the November 2007 Journal of the American Dietetic Association
9. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
10. November GEOLOGY and GSA TODAY Media Highlights
11. December GEOLOGY and GSA TODAY media highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Lithuania , Oct. 15, 2014   ... technologies, today announced the availability of the ... VeriLook Surveillance 3.0 provides real-time biometric face identification ... high-resolution digital surveillance cameras. The new version not ... and differentiates people from objects while they are ...
(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
(Date:10/14/2014)... N.Y. – Scientists have sequenced the house fly genome ... one might expect from an insect that thrives in ... published Oct. 14 in the journal Genome Biology ... biology and of how flies quickly adapt to resist ... Adult house flies (Musca domestica) carry and transmit more ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2House fly genome reveals expanded immune system 2
... the brain, cells called neurons go through a cycle ... Fernando Nottebohm, Ph.D., shows that these replaceable neurons share ... people with diseases such as Alzheimer's and Parkinson's: both ... , "It would be ironic if the shortfall in ...
... into the brain, researchers have treated a naturally occurring ... disease affecting the central nervous system to be successfully ... If this approach can be successfully applied to humans, ... entire class of diseases called lysosomal storage disorders which ...
... marine sponge is inspiring cutting-edge research in the design ... Barbara. , A report about these exciting new results ... story of the current issue of the scientific journal, ... Morse, professor of molecular, cellular and developmental biology at ...
Cached Biology News:One gene links newborn neurons with those that die in diseases such as Alzheimer's 2One gene links newborn neurons with those that die in diseases such as Alzheimer's 3One gene links newborn neurons with those that die in diseases such as Alzheimer's 4Genetic therapy reverses nervous system damage in animal model of inherited human disease 2Genetic therapy reverses nervous system damage in animal model of inherited human disease 3Marine sponge yields nanoscale secrets 2Marine sponge yields nanoscale secrets 3
(Date:10/20/2014)... , Oct. 20, 2014 Mapp Biopharmaceutical,s ... ZMapp™ antibody therapeutic to fight the Ebola outbreak ... and time-consuming the production of pharmaceuticals can be, ... publisher said that while some may be taken ... compound, those with industry knowledge are well aware ...
(Date:10/20/2014)... 2014  GenVec, Inc. (NASDAQ: GNVC ) today ... from its board of directors effective on October 24, 2014.  ... served as its chairman from June 2006 to November 2013.  ... Corporate Governance and Audit Committees of the board.  ... of dedicated service to GenVec, and its stockholders," said ...
(Date:10/19/2014)... Latin American hardware encryption display market report defines and ... forecast of revenue. This market was valued at $165.0 ... million by 2018, at a CAGR of 70.3% from ... the Latin American hardware encryption market report to get ... provides a glimpse of the segmentation of the market, ...
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Speech Analytics ... in Asia-Pacific with analysis and forecast of revenue. This ... 2014 to $208 million by 2019, at a Compound ... 2019. , Browse through the TOC of the Asia-Pacific ... the in-depth analysis provided. It also provides a glimpse ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Zola P. Horovitz To Retire From GenVec Board 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... One of the more hopeful promises of stem cells is ... that is not being met by organ donation. But experts expressed ... lead to backlash: among patients if cures do not materialize, and ... transplants are just one way that stem cells could be used ...
... like a man on the hot seat, at least not ... manage the State of Wisconsin's information technology consolidation gave a ... of a state audit, during a "Consolidation for Optimization" program ... Despite criticism of the results, Miszewski said the challenges facing ...
... the core of such major product suites as Microsoft's .NET, ... However, the very openness of SOA can disrupt the internal ... Oxley Act (SOX), the 2002 federal law that was enacted ... , ,A typical internal control over financial reporting for ...
Cached Biology Technology:Stem cells raise hopes, but is there money in them? 2Stem cells raise hopes, but is there money in them? 3Miszewski touts benefits of IT integration 2Miszewski touts benefits of IT integration 3Managing SOX in the age of SOA 2Managing SOX in the age of SOA 3Managing SOX in the age of SOA 4
... Combination inline heater plus multi-channel focal drug ... wash-out with a high-flow bath line while ... through the Perfusion Pencil.® Steady 37°C at ... bath line and tip. Advanced ...
...
... human angiogenin expressed in ... form: Lyophilized from a 0.2 ... buffered saline. Titertest method: ... Titertest values: capture ELISA 1-2 ...
Mouse Amphiregulin MAb (Clone 206220)...
Biology Products: