Navigation Links
Bio-inspired glue keeps hearts securely sealed
Date:1/8/2014

Boston, MA When a child is born with a heart defect such as a hole in the heart, the highly invasive therapies are challenging due to an inability to quickly and safely secure devices inside the heart. Sutures take too much time to stitch and can cause stress on fragile heart tissue, and currently available clinical adhesives are either too toxic or tend to lose their sticking power in the presence of blood or under dynamic conditions, such as in a beating heart.

"About 40,000 babies are born with congenital heart defects in the United States annually, and those that require treatment are plagued with multiple surgeries to deliver or replace non-degradable implants that do not grow with young patients," says Jeffrey Karp, PhD, Division of Biomedical Engineering, BWH Department of Medicine, co-senior study author of a new study that may improve how surgeons treat congenital heart defects.

The study will be published on January 8, 2014, in Science Translational Medicine.

In the preclinical study, researchers from Boston Children's Hospital, BWH and Massachusetts Institute of Technology (MIT) developed a bio-inspired adhesive that could rapidly attach biodegradable patches inside a beating heartin the exact place where congenital holes in the heart occur, such as with ventricular heart defects.

Recognizing that many creatures in nature have secretions that are viscous and repel water, enabling them to attach under wet and dynamic conditions, the researchers developed a material with these properties that also is biodegradable, elastic and biocompatible. According to the study authors, the degradable patches secured with the glue remained attached even at increased heart rates and blood pressure.

"This adhesive platform addresses all of the drawbacks of previous systems in that it works in the presence of blood and moving structures," says Pedro del Nido, MD, Chief of Cardiac Surgery, Boston Children's Hospital, co-senior study author. "It should provide the physician with a completely new, much simpler technology and a new paradigm for tissue reconstruction to improve the quality of life of patients following surgical procedures."

Unlike current surgical adhesives, this new adhesive maintains very strong sticking power when in the presence of blood, and even in active environments.

"This study demonstrated that the adhesive was strong enough to hold tissue and patches onto the heart equivalent to suturing," says the study's co-first author Nora Lang, MD, Department of Cardiac Surgery, Boston Children's Hospital. "Also, the adhesive patch is biodegradable and biocompatible, so nothing foreign or toxic stays in the bodies of these patients."

Importantly, its adhesive abilities are activated with ultraviolent (UV) light, providing an on-demand, anti-bleeding seal within five seconds of UV light application when applied to high-pressure large blood vessels and cardiac wall defects.

"When we attached patches coated with our adhesive to the walls of a beating heart, the patches remained despite the high pressures of blood flowing through the heart and blood vessels," says Maria N. Pereira, PhD, Division of Biomedical Engineering, BWH Department of Medicine, co-first study author.

The researchers note that their waterproof, light-activated adhesive will be useful in reducing the invasiveness of surgical procedures, as well as operating times, in addition to improving heart surgery outcomes.

"We are delighted to see the materials we developed being extended to new applications with the potential to greatly improve human life," said Robert Langer, ScD, MIT, study author.

The adhesive technology (and other related platforms) has been licensed to a start-up company, Gecko Biomedical, based in Paris. The company has raised 8 million Euros in their recently announced Series A financing round and expects to bring the adhesive to the market within two to three years.


'/>"/>

Contact: Lori J Schroth
ljschroth@partners.org
617-525-6374
Brigham and Women's Hospital
Source:Eurekalert  

Related biology news :

1. Army renews bio-inspired engineering and science research center at UC Santa Barbara with $48 million
2. Bio-inspired design may lead to more energy efficient windows
3. University of Tennessee engineering professor looks to whirligig beetle for bio-inspired robots
4. USC study reveals a protein that keeps people -- and their skeletons -- organized
5. MIT researchers reveal how the brain keeps eyes on the prize
6. Gene involved in neurodegeneration keeps clock running
7. Diversity keeps grasslands resilient to drought, climate change
8. Putting the spring back in broken hearts
9. Do mens and womens hearts burn fuel differently?
10. Nanomaterials key to developing stronger artificial hearts
11. RUB researchers find over active enzyme in failing hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bio-inspired glue keeps hearts securely sealed
(Date:6/21/2016)... Columbia , June 21, 2016 ... to the new role of principal product architect ... named the director of customer development. Both will ... chief technical officer. The moves reflect NuData,s strategic ... in response to high customer demand and customer ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... and BEIJING , Nov. 30, ... commercial provider of genomic services and solutions with cutting ... that it has completed a USD $75 Million [515 ... Co., Ltd.,s CMB International Capital Management ( Shenzhen ... Management Co., Ltd. ("SDIC Innovation") and Shanghai Sigma Square ...
(Date:11/30/2016)... Mass. , Nov. 30, 2016   Merck ... that it has entered into a set of agreements ... services for Merck,s collection of genetic reagents such as ... with Evotec,s screening expertise offers an accelerated pathway to ... discovery starts with the identification of new targets, a ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... development of a new orally administered treatment for Alzheimer’s disease (AD), today announced ... a Phase 2a clinical trial of T3D-959 in mild to moderate Alzheimer’s patients ...
(Date:11/30/2016)... ... 2016 , ... ProMIS Neurosciences (“ProMIS” or the “Company”), a ... announced that all five of its validated monoclonal antibody (mAb) therapeutic candidates for ... forms of Amyloid beta (Aß) in vitro. , “We previously demonstrated that the ...
Breaking Biology Technology: