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Date:10/24/2013

The molecular machine that makes essential components of ribosomes the cell's protein factories is like a Swiss-army knife, researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centro de Investigaciones Biolgicas in Madrid, Spain, have found. By determining the 3-dimensional structure of this machine, called RNA polymerase I, for the first time, the scientists found that it incorporates modules which prevent it from having to recruit outside help. The findings, published online today in Nature, can help explain why this protein works faster than its better-studied counterpart, RNA polymerase II.

"Rather than recruiting certain components from outside, RNA polymerase I has them already built in, which explains why it is bigger, and less regulated, but at the same time more efficient," says Christoph Mller from EMBL, who led the study. "Because everything is already assembled, there's no time delay," explains Maria Moreno-Morcillo, who carried out the work.

There are three different RNA polymerases, each of which makes specific types of RNA molecule. For example, RNA polymerase II makes messenger RNA the 'middle-man' that carries the information encoded in DNA to a ribosome where it can be used to make a protein. RNA polymerases I and III make parts of the machinery which reads that messenger RNA: I builds the RNA that will eventually form a ribosome, while III makes the transfer RNA that carries the protein building blocks to the ribosome for assembly. Scientists have known for over a decade what RNA polymerase II looks like and how it works, but obtaining detailed information on the structures of its counterparts has proven extremely difficult. Now that they have managed to do so for RNA polymerase I, Mller and colleagues have found explanations for some of the protein's particularities.

Part of the difficulty in studying RNA polymerase I is that it is a larger molecule than RNA po
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Contact: Sonia Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

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