Navigation Links
Big data analysis identifies prognostic RNA markers in a common form of breast cancer
Date:4/29/2013

COLUMBUS, Ohio A Big Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.

The study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) initially analyzed messenger RNA (mRNA) and microRNA expression, DNA methylation data and clinical findings for 466 patients with invasive ductal carcinoma, the most common type of breast cancer.

The analysis identified 30 mRNAs and seven microRNAs short snippets of RNA that were consistently associated with patient outcome across 44 clinical and molecular subclasses, including early-stage tumors. The researchers then validated the prognostic signature using genome-wide expression data from 2,399 breast-cancer patients in eight independent groups and found that it performed better than other RNA signatures currently used for breast-cancer risk stratification.

The findings are published in the Proceedings of the National Academy of Sciences.

"This is the first prognostic signature in breast cancer or other type of cancer that combines both mRNA and microRNA," says first author and researcher Dr. Stefan Volinia, associate professor of molecular virology, immunology and medical genetics at the OSUCCC James, "and we believe this concise RNA signature could prove useful for the clinical management of breast-cancer patients."

Principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics, notes that most of the genes involved in the RNA signature have not previously been linked to breast cancer and that unlike many other prognostic signatures, this one does not contain genes involved in the cell cycle or tumor grade.

"Most of these progno
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Turtle genome analysis sheds light on the development and evolution of turtle-specific body plan
2. Predicting the next eye pathogen; analysis of a novel adenovirus
3. Satellite sandwich technique improves analysis of geographical data
4. Market Analysis: Biomaterials and Engineered Protein
5. Genetic analysis saves major apple-producing region of Washington state
6. Genetic analysis calls for the protection of 2 highly endangered Portuguese fish species
7. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
8. Temp-controlled nanopores may allow detailed blood analysis
9. Biomass analysis tool is faster, more precise
10. Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals
11. Scientists publish analysis of algae parasite impact on algae biofuel in PLOS ONE
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has announced the ... report to their offering. ... in this market is the increasing demand for medical ... of patient data for quick and correct diagnosis during ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... Accounts of the tsunami that killed over a quarter of ... December, 2004, slowly disappear from the media, but the event ... are directly involved. In the aftermath of the disaster, academics ... of casualties could have been reduced and, more important, how ...
... to reduce the risk of stomach ulcers in people taking ... miscarriage, according to a study by researchers at the National ... Institutes of Health and other research institutions. , The study ... Medicine. , The drug, misoprostol, has been used to reduce ...
... –?from a search of 58,000 compounds –?that appear to ... of the three molecules protects the protein called "tau," ... with Alzheimer's. The finding is promising news for the ... co-director of the Neuroscience Research Institute at the University ...
Cached Biology News:Stem Cells to Solve the Blood Shortage Problem? 2Sleeping Sickness Epidemic Spreading in Uganda 2Sleeping Sickness Epidemic Spreading in Uganda 3Sleeping Sickness Epidemic Spreading in Uganda 4Scientists discover that three molecules may be developed into new Alzheimer's drugs 2Scientists discover that three molecules may be developed into new Alzheimer's drugs 3
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Dr. Greg Leyer ... 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics in ... is an annual continuing education conference for health care professionals. ... included the topic of probiotics in health. Dr. Leyer spoke ...
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015  El ... abre hoy su llamada a nominaciones para 2015. Este ... ha hecho, o tiene el potencial para hacer, contribuciones ... nominaciones se aceptarán hasta el 15 de marzo de ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... City, Mo. - The rate of entrepreneurial activity ... year-to-year shifts in gender, demographic, geographic and ethnic make-up ... according to a national assessment of entrepreneurial activity by ... Kauffman Index of Entrepreneurial Activity also reported a decline ...
... Memorial Day holiday is a paradox. It honors those who ... flags at gravestones and taps in the air, it is ... summer season and with sparkling weather framing joyous graduates, family ... the holiday holds its own festive note as well. I ...
... note: This is the 11th in a series of articles ... , , Madison, Wis. - You've ... equity funds, perhaps through investors. If you still need additional ... point, there are basic financial principles to consider. , ...
Cached Biology Technology:Kauffman study shows consistent entrepreneurial growth 2Who is minding the Innovation Gap? 2Who is minding the Innovation Gap? 3Who is minding the Innovation Gap? 4Who is minding the Innovation Gap? 5Who is minding the Innovation Gap? 6Who is minding the Innovation Gap? 7Who is minding the Innovation Gap? 8Early Stage: Step 11 - Other forms of finance 2Early Stage: Step 11 - Other forms of finance 3Early Stage: Step 11 - Other forms of finance 4
Anti-Mouse C-10, Biotin (Polyclonal) (rabbit IgG)...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
... Antibody is used to detect the appearance ... of infected cells as early as 8-24 ... the FastPlax Titer Kit, which allows determination ... The FastPlax Antibody can also ...
Alexa Fluor 647 anti-mouse IL-12 (Interleukin-12) / IL-23 (Interleukin-23) p40 25 ug...
Biology Products: